Navigation Links
Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
Date:12/10/2007

Troy, N.Y. Researchers at Rensselaer Polytechnic Institute have developed a new way to seek out specific proteins, including dangerous proteins such as anthrax toxin, and render them harmless using nothing but light. The technique lends itself to the creation of new antibacterial and antimicrobial films to help curb the spread of germs, and also holds promise for new methods of seeking out and killing tumors in the human body.

Scientists have long been interested in wrapping proteins around carbon nanotubes, and the process is used for various applications in imaging, biosensing, and cellular delivery. But this new study at Rensselaer is the first to remotely control the activity of these conjugated nanotubes. Details of the project are outlined in the article Nanotube-Assisted Protein Deactivation in the December issue of Nature Nanotechnology.

A team of Rensselaer researchers led by Ravi S. Kane, professor of chemical and biological engineering, has worked for nearly a year to develop a means to remotely deactivate protein-wrapped carbon nanotubes by exposing them to invisible and near-infrared light. The group demonstrated this method by successfully deactivating anthrax toxin and other proteins.

By attaching peptides to carbon nanotubes, we gave them the ability to selectively recognize a protein of interest in this case anthrax toxin from a mixture of different proteins, Kane said. Then, by exposing the mixture to light, we could selectively deactivate this protein without disturbing the other proteins in the mixture.

By conjugating carbon nanotubes with different peptides, this process can be easily tailored to work on other harmful proteins, Kane said. Also, employing different wavelengths of light that can pass harmlessly through the human body, the remote control process will also be able to target and deactivate specific proteins or toxins in the human body. Shining light on the conjugated carbon nanotubews" imgurl="http://image.bio-medicine.org/img/Using-carbon-nanotubes-to-seek-and-destroy-anthrax-toxin-and-other-harmful-proteins.gif" timex="12/10/2007 10:12:07 AM" dirsub="(s creates free radicals called reactive ...)" id="1517" index="biology" dir="Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins" dir2="Using carbon nanotubes to seek and destroy anthrax toxin and other harmfu..." keywords1=",biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters" keywords="Using,carbon,nanotubes,to,seek,and,destroy,anthrax,toxin,and,other,harmful,proteins" description="s creates free radicals called reactive oxygen species. It was the pr...Kanes new method for selective nanotube-assisted protein deactivation ...Kanes team also developed a thin clear film made of carbon nanotubes ...The ability of these coatings to generate reactive oxygen species upon...Kane said he and his team will continue to hone this new technology an..." url=u&"/biology-news-1/Using-carbon-nanotubes-to-seek-and-destroy-anthrax-toxin-and-other-harmful-proteins-1517-2/" title="Using%20carbon%20nanotubes%20to%20seek%20and%20destroy%20anthrax%20toxin%20and%20other%20harmful%20proteins" %> Using carbon nanotubes to seek and destroy anthrax toxin and other harmfu... ( Troy N.Y. Researchers at Rensselaer...)

Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
Date:12/10/2007

s creates free radicals, called reactive oxygen species. It was the presence of radicals, Kane said, that deactivated the proteins.

Kanes new method for selective nanotube-assisted protein deactivation could be used in defense, homeland security, and laboratory settings to destroy harmful toxins and pathogens. The method could also offer a new method for the targeted destruction of tumor cells. By conjugating carbon nanotubes with peptides engineered to seek out specific cancer cells, and then releasing those nanotubes into a patient, doctors may be able to use this remote protein deactivation technology as a powerful tool to prevent the spread of cancer.

Kanes team also developed a thin, clear film made of carbon nanotubes that employs this technology. This self-cleaning film may be fashioned into a coating that at the flip of a light switch could help prevent the spread of harmful bacteria, toxins, and microbes.

The ability of these coatings to generate reactive oxygen species upon exposure to light might allow these coatings to kill any bacteria that have attached to them, Kane said. You could use these transparent coatings on countertops, doorknobs, in hospitals or airplanes essentially any surface, inside or outside, that might be exposed to harmful contaminants.

Kane said he and his team will continue to hone this new technology and further explore its potential applications.


'/>"/>

Contact: Michael Mullaney
mullam@rpi.edu
518-276-6161
Rensselaer Polytechnic Institute  
Source:Eurekalert

Related biology news :

1. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
2. Fever causing headaches for Aussie parents
3. Using evolution, UW team creates a template for many new therapeutic agents
4. Using green chemistry to deliver cutting-edge drugs
5. IGERT fellows to design biodevices using flexible electronics
6. Prediction of RNA pseudoknots using heuristic modeling with mapping and sequential folding
7. Computer program traces ancestry using anonymous DNA samples
8. Using nanotubes to detect and repair cracks in aircraft wings, other structures
9. Book on weeds and invasive plants discusses how to manage them using ecological approaches
10. Study shows housing development on the rise near national forests
11. Rare cancer-causing syndrome found, for the first time, in Singapore
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins
(Date:5/12/2016)... May 12, 2016 WearablesResearch.com , a ... the overview results from the Q1 wave of its ... wave was consumers, receptivity to a program where they ... a health insurance company. "We were surprised ... says Michael LaColla , CEO of Troubadour Research, ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/28/2016)... 28, 2016 First quarter 2016:   ... compared with the first quarter of 2015 The gross ... M (loss: 18.8) and the operating margin was 40% (-13) ... Cash flow from operations was SEK 249.9 M (21.2) , ... is unchanged, SEK 7,000-8,500 M. The operating margin for ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... , June 24, 2016 Epic Sciences ... detects cancers susceptible to PARP inhibitors by targeting ... cells (CTCs). The new test has already been ... in multiple cancer types. Over 230 ... damage response pathways, including PARP, ATM, ATR, DNA-PK ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... release of its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering ... retention in this eBook by providing practical tips, tools, and strategies for clinical ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)... ... 23, 2016 , ... Charm Sciences, Inc. is pleased to ... AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of the ... Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform comparably ...
Breaking Biology Technology: