Navigation Links
Using bone marrow to protect the brain
Date:9/19/2011

The ability to produce neuroprotectors, proteins that protect the human brain against neurodegenerative disorders such as Parkinson's and ALS, is the holy grail of brain research. A technology developed at Tel Aviv University does just that, and it's now out of the lab and in hospitals to begin clinical trials with patients suffering from amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

Developed by Prof. Daniel Offen and Prof. Eldad Melamed of TAU's Sackler Faculty of Medicine and Felsenstein Medical Research Center, the technology is now a patent-pending process that takes stem cells from a patient's own bone marrow and causes them to differentiate into astrocyte-like cells, which are responsible for the well-being of the brain's neurons. The cells release neurotrophic factors, or neuroprotectants, which have been shown to play a key role in reducing the progress of ALS, a debilitating disease characterized by the progressive degeneration of motor neurons, resulting in paralysis of a patient's limbs and organ function.

The research has appeared in the Journal of Stem Cells Reviews and Reports and a number of other publications.

Trials in Jerusalem and Boston

This stem cell technology, says Prof. Offen, represents 10 years of development. Inspired by advances in embryonic stem cell research and its huge potential but trying to bypass the ethical and safety issues Prof. Offen and his fellow researchers turned to stem cells derived from a patient's own bone marrow.

After coaxing the cells to differentiate into astrocyte-like cells, whose natural function is to guard the brain's neurons and prevent deterioration, the researchers began testing the concept in animal models. "In the mouse model," Prof. Offen explains, "we were able to show that the bone marrow derived stem cells prevent degeneration in the brain following injection of selective neurotoxins." Researchers also demo
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New data from studies bolsters case for using aldosterone antagonists in heart failure
2. A 3-D reconstructed image of neural dendritic trees using the advanced electron microscope technology
3. Using a mathematical model to evaluate microsatellite genotyping from low-quality DNA
4. Lack of free play among children is causing harm, say experts in American Journal of Play
5. UC Davis researchers find disease-causing fat cells in those with metabolic syndrome
6. Using a systems biology approach to look under the hood of an aggressive form of breast cancer
7. BUSM awarded $9 million to investigate treatment for sickle cell disease using iPS cells
8. For the first time, the European IVF Monitoring Group reports on cycles using frozen eggs
9. Using DNA in fight against illegal logging
10. Using olive oil in your diet may prevent a stroke
11. Using living cells as an invisibility cloak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... of the amphibians with the highest distribution in the ... water where it comes into contact with the red ... out by the Spaniard Germn Orizaola from the University ... frogs have developed a defensive response to the invasive ... if they co-exist with the crayfish. , Numerous invasive ...
(Date:7/9/2014)... laboratory testing, countless measurement results accrue. To completely ... extremely time consuming. In fact, researchers in the ... managing data, according to an online survey of ... the Fraunhofer Institute for Applied Information Technology FIT ... that they have no centralized or structured approach ...
(Date:7/9/2014)... inhibitors and N-methyl-D-aspartate receptor antagonists can alleviate ... to affect irreversible cognitive dysfunction and effectively ... Amyloid beta peptide (Aβ) vaccines reduced and ... (AD) transgenic mouse model, and significantly improved ... and his team, First Affiliated Hospital of ...
Breaking Biology News(10 mins):Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Managing the data jungle 2Managing the data jungle 3
... researchers have sequenced the genomes of two bacteria that ... Brazil and elsewhere. , The researchers are now analysing ... that could be used to develop vaccines and diagnostic ... in pigs and costs the Brazilian pig-breeding industry US$200 ...
... once were bountiful in an area near the town of ... grew more plentiful, browsing heavily on young willows. Today, there ... warblers in what is now a grassland meadow. These profound ... top predator. That's the compelling finding of the paper, "Human ...
... of boosting the yield of a major crop by stopping ... is the most important oilseed crop in India after groundnut. ... seeds. However, because the seedpods open naturally to disperse their ... , This 'pod shatter' also makes it difficult for farmers ...
Cached Biology News:Wolves' top-down effect 2
(Date:1/15/2014)... 2014 The Pittcon Organizing Committee is pleased ... Safety Tech , an e-Journal and producer of ... the second year for the co-location of Food Labs Conference ... provides that the registration fee to attend the two-day Food ...
(Date:1/15/2014)... 2014 ­ RedBrick Health , a fast-growing leader ... announces that EmblemHealth , the New ... now providing the RedBrick Compass health assessment, combined with ... of its members. EmblemHealth is among the first health ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how ... latent viruses is the Epstein Barr Virus (EBV), and one ... is a chronic inflammatory disease that destroys the body’s joints. ... patients have high concentrations of EBV DNA in their bodies ...
(Date:1/15/2014)... TaiGen Biotechnology Company, Limited ("TaiGen") today announced that ... leading Russian pharmaceutical company, to develop and commercialize nemonoxacin ... , Turkey and other ... novel antibiotic for the treatment of bacterial infections including ...
Breaking Biology Technology:Pittcon Announces Second Year Partnership With Food Safety Tech 2Pittcon Announces Second Year Partnership With Food Safety Tech 3EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 2EmblemHealth Selects RedBrick Health to Power its Next-Generation Health Engagement and Behavior Change System 3Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4
... Editors note: This is the first of a series of columns ... and advice on IT leadership and the challenges they face. ... 95 percent of his customers want more of what he has ... ready to meet that demand. , ,David Wallace is the CIO ...
... arteries. Source: National Institutes of Health. Madison, Wis. ... researcher, announced on Wednesday that it will receive a $1.26 ... National Institutes of Health. , ,The funds will be used ... anemia, a blood disorder that kills red blood cells. This ...
... getting a flu shot this season and you want to fix ... mirror. If the face you see belongs to someone who buys ... the problem. , ,The looming shortage of flu vaccine comes down ... in the business of making vaccines. Why? The capital costs are ...
Cached Biology Technology:MATC faces demand for less paper and more integration 2MATC faces demand for less paper and more integration 3Mirus receives $1.26 million SBIR grant to combat anemia 2Want to squeeze U.S. pharmaceutical companies? Be careful what you ask for 2Want to squeeze U.S. pharmaceutical companies? Be careful what you ask for 3
... amino acid synthetic peptide whose sequence is from rat SCAMP 5. ... C - N(217) - Q - P - Q - ... - P - N - Y - T - Y - ... neutralization and control experiments with the polyclonal antibody that reacts with ...
... output accessory lessens the expensive task ... laboratories with multiple mass spectrometers. It ... from Agilent 1100 Series LC/MSD quadrupole ... transmits the analog data directly to ...
... DSQ II (Dual-Stage Quadrupole) Thermo Scientific ... leader in analytical instrumentation, introduces the latest ... DSQ II. Based on the proven reliability ... PolarisQ GC/MS systems, the DSQ II incorporates ...
... variant: With the macro- and ... and Skoog (1962) and the ... et al. (1968). Preparation Quantity ... grams of powder per liter ...
Biology Products: