Navigation Links
Using bone marrow stem cells to treat critically ill patients on verge of respiratory failure
Date:8/11/2010

ome cases, acute lung injury develops into a more serious condition, known as acute respiratory distress syndrome, and results in insufficient oxygenation of blood and eventual organ failure.

Buried in the depths of healthy lung tissue, tiny groups of cells called alveoli stretch open to accommodate oxygen with each breath and then remove carbon dioxide during exhalation. Each alveolus is lined with a layer of epithelial cells that serve as a critical barrier -- keeping certain substances in and certain substances out -- so that the gas balance inside is appropriately maintained.

In contrast, inflammation due to injury or infection can make the border of epithelial cells become more porous than it should be. The increased permeability allows an often-deadly mix of substances, such as fluid and cells, to seep into and accumulate in the alveoli.

Despite extensive research on acute lung injury and acute respiratory distress syndrome, the mortality rate for patients remains high -- at about 40 percent, Lee said, and pharmacological therapies that reduce the severity of lung injury in experimental studies have not yet translated into effective clinical treatment options.

"Current treatments are primarily supportive care, and, therefore, innovative therapies are needed," explained co-author Arne P. Neyrinck.

The team decided to re-create the unhealthy lung conditions in the lab -- by culturing human alveolar cells and then chemically causing inflammation -- and to observe how the presence of bone marrow stem cells would change things.

"We then introduced mesenchymal stem cells without direct cell contact, and they churned out a lot of protein, called angiopoietin-1, which prevented the increase in lung epithelial permeability after the inflammatory injury," said Xiaohui Fang, the first author of the manuscript.

The authors say the findings are the first to demonstrate how mesenchymal stem cells revive the
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
2. Health care using telephone and telemonitoring technology benefits heart failure patients
3. Cancer-causing bacterium targets tumor-suppressor protein
4. Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
5. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
6. Using bacteria in oil wells to convert oil to natural gas
7. Study of severe asthma using CT scans
8. Ph.D. thesis opens doors to obtaining chemical products and materials using biomass as raw material
9. Using fish to illuminate the architecture of inherited disease
10. UCLA engineer gets $4 million from Department of Energy to convert CO2 to liquid fuel using electricity
11. Using remote sensing to track invasive trees
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using bone marrow stem cells to treat critically ill patients on verge of respiratory failure
(Date:9/19/2014)... will study the unique bioelectric signaling system of the ... health. The OU researcher is working to understand ... the signals used to map the world around them. ... of 500-600 discharges a second throughout their lives. ... extreme, but necessary for survival. , "There is evidence ...
(Date:9/19/2014)... did not evolve for the sake of fairness per ... continued cooperation, so say Frans de Waal, PhD, and ... inequity aversion (IA), which is defined as a negative ... Science . , Their conclusion comes after ... address their hypothesis that it is the evolution of ...
(Date:9/19/2014)... 19, 2014 Nxt-ID, Inc. (Nasdaq: NXTD ... on the growing m-commerce market, updates the "Wocket in Your Pocket" ... lightweight and light middleweight weight classes, Vinny Pazienza (PAZ). ... that Game of Thrones actor Ciaran Hinds ... star Katey Sagal have been cast in ...
Breaking Biology News(10 mins):Evolution of responses to (un)fairness 2Evolution of responses to (un)fairness 3NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3
... of metagenomics, where the DNA of entire communities of ... perhaps since the invention of the microscope -- to ... report from the National Research Council. The report ... advances in the field in the same way that ...
... in an East Tennessee valley adjacent to the Oak ... from weapons manufacturing at the facility between 1951 and ... for miles from the contaminated site. , But ... his FSU oceanography department team will help clean up ...
... of growth hormone to boost athletic performance can lead to ... British Journal of Sports Medicine. , The study reports the ... emergency care for chest pain. , He had lost ... experienced excessive urination, thirst, and appetite. , He admitted ...
Cached Biology News:New science of metagenomics 'will transform modern microbiology' 2New science of metagenomics 'will transform modern microbiology' 3New science of metagenomics 'will transform modern microbiology' 4'Hidden-hero' microbes in soil, water may help naturally clean toxic sites 2
(Date:9/19/2014)... 19, 2014  InterMune, Inc. (Nasdaq: ITMN ... of Understanding to settle the litigation in the Delaware ... of Merger dated as of August 22, 2014, among ... As one term of the Memorandum of Understanding, the ... in the attached exhibit reflecting the amendment to the ...
(Date:9/19/2014)... at NYU Langone Medical Center have found a way ... for turning adult cells into so-called pluripotent stem cells ... the new technique in mice, the researchers increased the ... by more than 20-fold compared with the standard method. ... thus should generally accelerate research aimed at using stem ...
(Date:9/19/2014)... California (PRWEB) September 19, 2014 ... and its potential to revolutionize the world has ... multinational corporations and small start-ups. The early years ... research projects largely due to the high risks ... Government budgets earmarked for this evolving technology have ...
(Date:9/19/2014)... Florida , September 19, 2014 ... medical technology, development of emerging drug systems and advanced ... Benton, Dickinson and Company (NYSE: BDX ), ... Regado Biosciences Inc. (NASDAQ: RGDO ), Sangamo ... Inc. (NASDAQ: HOLX) Pressure BioSciences, Inc. (OTCQB: ...
Breaking Biology Technology:InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 2InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 3InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 4InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 5InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 6InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 7InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 8InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 9InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 10InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 11InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 12InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 13InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 14InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 15InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 16InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 17InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 18InterMune Reports Memorandum of Understanding in Connection with Consolidated Delaware Action 19NYU Langone scientists report reliable and highly efficient method for making stem cells 2NYU Langone scientists report reliable and highly efficient method for making stem cells 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 2Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 3Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 4Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 5Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 6Medical Instrumentation Automation Advances for Biological Sample Preparation - Company Expects Q4 Revenue Impact from Newest Instrument Systems 7
... Shire plc (LSE: SHP,NASDAQ: SHPGY ... co-promotion agreement with GlaxoSmithKline plc (NYSE: ... the aim of,improving recognition and treatment of ADHD ... States and will more than double the reach ...
... IN ITALY AND ALL IPLEX(TM) INITIATIVES IN THE U.S. ... , RICHMOND, Va., March 30 Insmed Inc. ... announced the signing of an agreement with IDIS, a ... on a named patient basis, also known as expanded ...
... 30 BioMedical Enterprises, Inc. (BME), a rapidly growing ... orthopaedic memory metal implants, announced today that it has ... and Marketing. BME specializes in nitinol implants that ... together to promote bone union. The O ...
Cached Biology Technology:Shire and GlaxoSmithKline Enter Agreement to Co-promote VYVANSE(R) (lisdexamfetamine dimesylate) CII for the Treatment of Adults With ADHD 2Shire and GlaxoSmithKline Enter Agreement to Co-promote VYVANSE(R) (lisdexamfetamine dimesylate) CII for the Treatment of Adults With ADHD 3Shire and GlaxoSmithKline Enter Agreement to Co-promote VYVANSE(R) (lisdexamfetamine dimesylate) CII for the Treatment of Adults With ADHD 4Shire and GlaxoSmithKline Enter Agreement to Co-promote VYVANSE(R) (lisdexamfetamine dimesylate) CII for the Treatment of Adults With ADHD 5Shire and GlaxoSmithKline Enter Agreement to Co-promote VYVANSE(R) (lisdexamfetamine dimesylate) CII for the Treatment of Adults With ADHD 6Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 2Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 3Insmed Announces Agreement With IDIS to Manage Expanded Access Programs for IPLEX(TM) 4BioMedical Enterprises, Inc. (BME) Announces the Appointment of Keith M. Peeples as Vice President, Sales and Marketing 2
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Maize microRNA Microarray contains ...
... LTQ XL extends the legendary MSn performance ... generate structural information through Thermo Scientifics innovations ... LTQ XL is the only mass spectrometer ... and CID. Pulsed Q Collision Induced ...
... is a rugged, compact, lab-quality ... information you need - at ... of gas mixtures is critical, ... generates more data in less ...
... PolarScreen Peroxisome Proliferator-Activated Receptor-gamma (PPARGamma) ... sensitive and efficient method for ... ligands using fluorescence polarization (FP). ... binding domain (PPARGamma-LBD) with an ...
Biology Products: