Navigation Links
Using bone marrow stem cells to treat critically ill patients on verge of respiratory failure
Date:8/11/2010

BETHESDA, Md., Aug. 11, 2010 - Researchers are reporting this week new study results they say provide further evidence of the therapeutic potential of stem cells derived from bone marrow for patients suffering from acute lung injury, one of the most common causes of respiratory failure in intensive care units.

Led by Drs. Michael A. Matthay and Jae W. Lee at the Cardiovascular Research Institute of the University of California, San Francisco, the team writes in a Journal of Biological Chemistry "Paper of the Week" that its experiments have revealed how a type of bone marrow stem cell bolsters damaged lung cells.

"We found that these stem cells secreted a significant quantity of a protein that restored the barrier that keeps fluid and other elements out of the lungs," said Lee, an associate professor of anesthesia at UCSF. "We're optimistic about the promise that future clinical trials may hold."

Scientists for decades have harnessed the natural regenerative properties of bone marrow to treat patients with blood-related diseases. And, of late, investigations into the potential of using bone marrow stem cells to treat damaged tissues have intensified.

There are two types of stem cells in bone marrow. One kind, hematopoietic stem cells, is tasked with producing red and white blood cells, depending upon the immune system's needs. The other, mesenchymal stem cells, is the focus of Matthay and Lee's work. While mesenchymal stem cells also support the production of blood cells, scientists today are quite interested in their ability to differentiate into cells that, when mature, develop into tissues throughout the body.

"Within the past several years, there has been an increased interest in understanding the biology of stem cells for clinical use as cell-based therapies," Lee said.

Acute lung injury is brought on by a number of conditions, such as pneumonia and sepsis, also known as blood poisoning. In s
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Rutgers researchers assess severity of prostate cancers using magnetic resonance imaging
2. Health care using telephone and telemonitoring technology benefits heart failure patients
3. Cancer-causing bacterium targets tumor-suppressor protein
4. Noninvasive MR imaging of blood vessel growth in tumors using nanosized contrast agents
5. Researchers develop drug delivery system using nanoparticles triggered by electromagnetic field
6. Using bacteria in oil wells to convert oil to natural gas
7. Study of severe asthma using CT scans
8. Ph.D. thesis opens doors to obtaining chemical products and materials using biomass as raw material
9. Using fish to illuminate the architecture of inherited disease
10. UCLA engineer gets $4 million from Department of Energy to convert CO2 to liquid fuel using electricity
11. Using remote sensing to track invasive trees
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Using bone marrow stem cells to treat critically ill patients on verge of respiratory failure
(Date:9/18/2014)... researchers from McGill University and the Quebec government ... ,microbeads, Canadian Journal of Fisheries and Aquatic ... cosmetics, household cleansers, or industrial cleansers, to which ... their small size and buoyancy, they may readily ... a global contaminant in the world,s oceans, but ...
(Date:9/18/2014)... No matter how many times it,s demonstrated, it,s ... creatures. , But by using a signaling ... alter their behavior to suit their population. In ... are present, and act accordingly. , Once the ... may change from innocuous to pathogenic, or from ...
(Date:9/18/2014)... language is unique to humans. "The genetic changes that ... evolution to make this possible are largely unknown, but ... says Wolfgang Enard, Professor of Anthropology and Human Biology ... biological basis of language Enard has now taken an ... undertaken in collaboration with scientists at several universities, including ...
Breaking Biology News(10 mins):Microplastic pollution discovered in St. Lawrence River sediments 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 2Researchers study vital 'on/off switches' that control when bacteria turn deadly 3Language evolution: Quicker on the uptake 2Language evolution: Quicker on the uptake 3
... University Feinberg School of Medicine played a significant ... Abraxane (paclitaxel protein-bound particles for injectable suspension), indicated ... approval means that women with metastatic breast cancer ... with solvents and will no longer need steroid ...
... In laboratory mouse experiments, researchers at The University of ... way to use RNA interference (RNAi) so that it ... activated STAT3, a crucial gene found in some human ... invasive. , The study, presented at the annual meeting ...
... provide for study of human immune responses, scientists have ... rapid immune response by two separate armies of defensive ... microbes like the leprosy bug, this initial defense sometimes ... yields to a dangerous, spreading infection. , Led by ...
Cached Biology News:Nanoparticle Breast Cancer Drug Approved by FDA 2Used in a new way, RNA interference permanently silences key breast cancer gene 2Leprosy microbes lead scientists to immune discovery 2
(Date:9/19/2014)... California (PRWEB) September 19, 2014 ... and its potential to revolutionize the world has ... multinational corporations and small start-ups. The early years ... research projects largely due to the high risks ... Government budgets earmarked for this evolving technology have ...
(Date:9/19/2014)... SAN FRANCISCO , Sept. 19, 2014 /PRNewswire/ ... announced results from preclinical studies characterizing the analgesic ... oral, peripherally-acting kappa opioid receptor agonist molecules. The ... molecule polymer medicinal chemistry platform. The ... described in the medical literature. 1,2 Kappa ...
(Date:9/19/2014)... 19, 2014 Barnhardt Manufacturing Company ... for its Organic Cotton . The USDA Certified ... renewable biobased ingredients meets or exceeds levels set by ... in whole or in significant part of agricultural, forestry, ... our Organic cotton to be immediately identified as a ...
(Date:9/19/2014)... -- , The first grants awarded to ... (ESPE) Meeting  Investment supports innovative projects for ... field of growth  , EMD Serono, a ... , today announced the first recipients of the Grant ... announced during a Satellite Symposium organized by EMD Serono ...
Breaking Biology Technology:Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 2Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 3Growing R&D Investments & Developments in Nanomaterials to Drive the Global Nanotechnology Market, According to New Report by Global Industry Analysts, Inc. 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 2Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 3Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 4Nektar Presents Positive Preclinical Data on Oral, Peripherally-Acting Kappa Agonist Molecules at 2014 American Academy of Pain Management Meeting 5Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3
... , , HUNTERSVILLE, N.C., ... leader in built-in antimicrobial product protection, has partnered with YogaDirect.com, ... the U.S., to launch the first ever line of yoga ... of yoga mats that will stay cleaner and fresher for ...
... , DOYLESTOWN, Pa., July 28 ... company to offer a broad range of accredited CME courses in ... clinical trials. , , The comprehensive education and ... Institute (BRITI)(TM). RadMD is partnering with International Center for Postgraduate Medical ...
... , , WESTFORD, Mass., July ... manufacturer of a broad array of light-based aesthetic treatment systems, today announced financial ... Second Quarter 2009 Financial Results , , ... with $39.2 million in the same period of 2008 and $14.8 million in ...
Cached Biology Technology:Microban Partners With YogaDirect.com to Launch Yoga Mats With Zinc Antimicrobial Technology 2RadMD First to Offer CME-Certified Education and Training For Medical Imaging in Clinical Trials 2Cynosure Reports Second Quarter 2009 Financial Results 2Cynosure Reports Second Quarter 2009 Financial Results 3Cynosure Reports Second Quarter 2009 Financial Results 4Cynosure Reports Second Quarter 2009 Financial Results 5Cynosure Reports Second Quarter 2009 Financial Results 6Cynosure Reports Second Quarter 2009 Financial Results 7Cynosure Reports Second Quarter 2009 Financial Results 8Cynosure Reports Second Quarter 2009 Financial Results 9Cynosure Reports Second Quarter 2009 Financial Results 10Cynosure Reports Second Quarter 2009 Financial Results 11Cynosure Reports Second Quarter 2009 Financial Results 12Cynosure Reports Second Quarter 2009 Financial Results 13
... The four-bay DNA Engine Tetrad ... of interchangeable Alpha units (sample-holder, heat-pump ... numbers of vessels. A Pentium-class computer ... displays current block, sample, and lid ...
Printer paper for Model 680 series readers is used with the thermal printers of the Model 680 and Model 680 XR microplate readers. Supplied as 2 rolls....
... for 2-D separations. The cell has a six-gel ... xi multi-cell can be customized for several parameters: ... cooling system. The PROTEAN II xi multi-cell can ... multi-cell for a wider format that accommodates 17 ...
... is tailored to highly enrich ... rat spleen cells. Cells are ... compatible 0.5 Tesla) immunomagnetic negative ... content of the enriched fraction ...
Biology Products: