Navigation Links
Using big data to identify prostate cancers and best treatments
Date:5/23/2013

the costs can be astronomical. For example, radiation therapy always destroys healthy tissue. Rectal toxicity can be caused by radiation spillover from prostate treatment, he explained. Use of a proton gun to treat prostate cancer reaches about $125,000 per patient.

In their search for cues that help identify very low-risk prostate cancer and the best treatments for each form, the researchers are looking at data from 300 men, half who chose immediate surgery after diagnosis and half who chose to have their cancer monitored.

Researchers at Johns Hopkins are focusing on molecular biomarkers from tissue samples of prostate cancers. They are looking at a set of five unique biomarkers to separate the very low-risk group from the low-risk, intermediate-risk and high-risk groups.

The Case Western Reserve researchers are undertaking a quantitative computerized image analysis-based study of the organization and structure of diseased tissues. Specifically, they are looking for differences in the shape and size and architecture of nuclei within the tissue, as well as the shape of the cross-sections of glands in the samples. All can indicate the disease's aggressiveness and characteristics.

The data comes from digitized images of biopsy slides. A simple biopsy image of prostate cancer digitized via a whole slide scanner can be several gigabytes in size. In a typical biopsy procedure, 10 to 12 samples are removed and, after those are laid out on slides and digitized, that translates to hundreds of gigabytes of data.

"All of this data is a challenge and opportunity; the words go hand in hand," Madabhushi said. "How we deal with it all is a challenge, but the opportunity is in what it can tell us. There's so much we don't know and there's only so much a pathologist can tell us. There's a limit to how much time a pathologist can spend analyzing a glass slide."

The researchers write and employ algorithms, which are programs enc
'/>"/>

Contact: Kevin Mayhood
kevin.mayhood@case.edu
216-368-4442
Case Western Reserve University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Stanford engineers monitor heart health using paper-thin flexible skin
2. Bird flu in live poultry markets are the source of viruses causing human infections
3. Mutation causing wrong-way plumbing explains 1 type of blue-baby syndrome
4. Using bacteria-eaters to prevent infections on medical implant materials
5. Neiker-Tecnalia and FARMARABA produce Omega 3 using marine plant micro-organisms
6. Source identification of H7N9 influenza virus causing human infections
7. Virtual, squishy creatures evolve to run using evolutionary algorithms
8. Federal Government Organization achieves cleaner and faster Clinical Study Data using Tablet PCs from TabletKiosk
9. Metabolic fingerprinting: Using proteomics to identify proteins in gymnosperm pollination drops
10. Symbiotic bacteria program daily rhythms in squid using light and chemicals
11. Researchers discover brain cancer treatment using genetic material from bone marrow cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... new report from the Wildlife Conservation Society shows ... help economically valuable species such as lobster, conch, ... help re-colonize nearby reef areas. , The reporttitled ... systematic review of research literature from no-take areas ... Dr. Craig Dahlgren, a recognized expert in marine ...
(Date:7/11/2014)... were many fires burning in eastern New South Wales, ... 11. , At 03:35 UTC on July 11 (12:35 ... Aqua passed over eastern New South Wales (NSW), the ... visible image of the region and spotted smoke (light ... MODIS,s thermal bands, are outlined in red. , The ...
(Date:7/11/2014)... and Mineral Research awarded Michael F. Holick, PhD, MD, ... 2014 Louis V. Avioli Award. Holick, a professor of ... for revolutionizing the understanding of vitamin D and its ... a member of the American Society for Bone and ... mineral basic research. It is named for ASBMR,s first ...
Breaking Biology News(10 mins):Belize's lobster, conch, and fish populations rebuild in no-take zones 2BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... from the Buck Institute for Age Research offers a ... neurodegenerative disorder which afflicts 24 million people worldwide. ... a protein implicated in AD, scientists in California and ... a new therapeutic target for the disease. The finding ...
... fish do it. But Prof. Yossi Loya from Tel Aviv ... to discover that Japanese sea corals engage in "sex switching" ... survival of fragile sea corals ― essential to all life ... In times of stress like extreme hot spells, the ...
... group of scientists is renewing calls for policymakers to ... eutrophication or nutrient pollution problems in fresh ... Science , the researchers argue that dual-nutrient reduction ... complex interactions between nitrogen and phosphorus in fresh and ...
Cached Biology News:A revolutionary new model for Alzheimer's disease 2Changing sexes on the sea floor 2
(Date:7/10/2014)... Ouagadougou, Burkina Faso (PRWEB) July 10, 2014 ... Burkina Faso, today have access to an additional ... to increase access to contraception at all levels ... combining a lower-dose formulation of a widely used ... injection system. , Burkina Faso is the first ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... (PRWEB) July 10, 2014 Robert Harman, DVM, ... Medicine company, is proud to announce the relaunch of his ... with a new series called “ What are Stem Cells ... an honest and straightforward foundation in the basics of stem ... decision on the right type of treatment when considering regenerative ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Senior ... institutions and professional associations, addressed the challenges of “Reducing ... Medical Device Industries” through strategic sourcing. Describing the partnership ... with the Supply Chain Management Institute ( SCMI) ... event on June 24 at the Kroc Institute of ...
Breaking Biology Technology:Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 2Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 3Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 4Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 5Injectable Contraceptive Launched in Burkina Faso to Expand Choice and Address Unmet Need 6Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 2Robert Harman, DVM Talks About What Stem Cells are in His Latest Blog Series for Vet-Stem, Inc. 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 2Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 3Biotech & Biopharm Supply Chain Management Executives Launch BSMA in San Diego 4
... Nev., Sept. 30, 2011 Lifeline Biotechnologies, Inc. (Pink Sheets: ... efforts to reestablish DTC services. Jim Holmes, Lifeline,s ... services to the Company we have not been successful.  We ... The value of Lifeline is not reflected in ...
... , SALT LAKE CITY, Sept. 29, 2011 University of ... catalysts, which are substances that speed chemical reactions and are ... the new method, the chemists also made a discovery that ... discovery: the sizes and electronic properties of catalysts interact to ...
... BioSpace , the leading life sciences employment and ... marking the 14th edition. (Logo: http://photos.prnewswire.com/prnh/20040907/CLTU006LOGO) ... Each company,s brand is added to an electronic and ... as well as at industry events and career fairs. ...
Cached Biology Technology:Lifeline Biotechnologies and Depository Trust Company 2Building better catalysts 2Building better catalysts 3BioSpace Spotlights Southern California's Life Science Community 2
... Andrew J. Davison and ... • Contents include: information ... viruses, paramyxoviruses, influenza and ... covers analysis of viral ...
... U. Desselberger (1995) • This book ... together classical and molecular techniques currently ... infections and analysis of virus-specific antibodies ... are presented covering immunoassays, blotting and ...
...
... provide rapid and efficient removal of short ... salts from PCR products (Figure 1). The ... Binding Buffer options for fragments >100 bp ... in either single column or 96-well plate ...
Biology Products: