Navigation Links
Using artificial, cell-like 'honey pots' to entrap deadly viruses
Date:3/2/2011

Researchers from the National Institute of Standards and Technology (NIST) and the Weill Cornell Medical College have designed artificial "protocells" that can lure, entrap and inactivate a class of deadly human virusesthink decoys with teeth. The technique offers a new research tool that can be used to study in detail the mechanism by which viruses attack cells, and might even become the basis for a new class of antiviral drugs.

A new paper* details how the novel artificial cells achieved a near 100 percent success rate in deactivating experimental analogs of Nipah and Hendra viruses, two emerging henipaviruses that can cause fatal encephalitis (inflammation of the brain) in humans.

"We often call them honey pot protocells," says NIST materials scientist David LaVan, "The lure, the irresistibly sweet bait that you can use to capture something."

Henipaviruses, LaVan explains, belong to a broad class of human pathogensother examples include parainfluenza, respiratory syncytial virus, mumps and measlescalled enveloped viruses because they are surrounded by a two-layer lipid membrane similar to that enclosing animal cells. A pair of proteins embedded in this membrane act in concert to infect host cells. One, the so-called "G" protein, acts as a spotter, recognizing and binding to a specific "receptor" protein on the surface of the target cell.

The G protein then signals the "F" protein, explains LaVan, though the exact mechanism isn't well understood. "The F protein cocks like a spring, and once it gets close enough, fires its harpoon, which penetrates the cell's bilayer and allows the virus to pull itself into the cell. Then the membranes fuse and the payload can get delivered into the cell and take over." It can only do it once, however.

The "honey pot" protocells have a core of nanoporous silicainert but providing structural strengthwrapped in a lipid membrane like a normal cell. In this membrane the research team em
'/>"/>

Contact: Michael Baum
michael.baum@nist.gov
301-975-2763
National Institute of Standards and Technology (NIST)
Source:Eurekalert

Page: 1 2

Related biology news :

1. Cancer-causing virus exploits key cell-survival proteins
2. Using EEGs to diagnose autism spectrum disorders in infants
3. Cold cases gone hot: Montreal researchers solve decades-old medical mysteries using genetics
4. Using a childs own stem cells to repair their heart looks promising
5. The world can be powered by alternative energy, using todays technology, in 20-40 years
6. Researchers register new species using DNA-based description
7. Forum to focus on using robotics, imaging and simulation in surgeries
8. EU grant for better monitoring of Crohns disease using MRI
9. Despite damage, membrane protein structure can be seen using new X-ray technology, study reveals
10. Cholera strain evolves new mechanism for causing disease
11. Using chaos to model geophysical phenomena
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... a sparrow-sized fossil from China challenges the commonly held ... gained the ability to fly. The birdlike fossil is ... rather the remains of a tiny tree-climbing animal that ... Dinosaur Museum in Blanding, Utah, and Alan Feduccia of ... Springer,s Journal of Ornithology . , The fossil ...
(Date:7/9/2014)... of the amphibians with the highest distribution in the ... water where it comes into contact with the red ... out by the Spaniard Germn Orizaola from the University ... frogs have developed a defensive response to the invasive ... if they co-exist with the crayfish. , Numerous invasive ...
(Date:7/9/2014)... measurement results accrue. To completely and systematically archive ... In fact, researchers in the life sciences spend ... to an online survey of 70 people working ... for Applied Information Technology FIT in Sankt Augustin. ... no centralized or structured approach to data collection ...
Breaking Biology News(10 mins):Researchers declassify dinosaurs as being the great-great-grandparents of birds 2Frogs have developed rapid defences against the red swamp crayfish 2Frogs have developed rapid defences against the red swamp crayfish 3Managing the data jungle 2Managing the data jungle 3
... The replanting of mangroves on the coasts of the Philippines ... 20-30 typhoons that hit the islands annually. This is ... immediate and massive mangrove replanting, that J.H. Primavera from the ... La Salle University, both in the Philippines, cite in a ...
... billion tons of microbial organismsexpressed in terms of carbon ... published online by Nature , July 20, 2008. ... of carbon stored globally in tropical rainforests. The authors: ... Marine Environmental Sciences (MARUM) at University of Bremen, Germany; ...
... of the nickel metal hydride (NiMH) technology used for ... hybrid gas-electric cars believes the hydrogen economy is already ... the current issue of the International Journal of ... and CEO of Ovshinsky Innovation LLC, based in Bloomfield ...
Cached Biology News:Mangroves key to saving lives 2Nature publishes new evidence about the deep biosphere written by biogeoscientists 2Nature publishes new evidence about the deep biosphere written by biogeoscientists 3Closing the hydrogen economic loop 2
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014  Organovo announced ... from the National Institutes of Health (NIH) to help ... effective treatments to patients on a faster timeline. Organovo ... Sciences (NCATS) and the National Eye Institute (NEI) to ...
(Date:1/14/2014)... 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a ... innovative therapies addressing major unmet medical needs using ... Notice of Allowance from the United States Patent ... compounds (sd-rxRNA®), for the treatment of fibrosis. The ...
(Date:1/14/2014)... USA, and Cardiff, UK (PRWEB) January 13, 2014 ... technology development leader with more than 20 years in ... for optics and photonics . Hainsey will serve as ... delighted to have Dr. Hainsey join SPIE as our ...
(Date:1/14/2014)... Independent publisher Bitingduck Press, with offices in Altadena ... ideas for 2014 in production and sales of interactive ... high-quality, low-cost, DRM-free ebooks and to use the sales ... first major development will be bookstore sales in local ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... PHILADELPHIA, May 28 Premier Research Group plc ... of Anthony Faragasso, MD as Executive Director and ... position, Dr. Faragasso will lead,the global Medical Management ... and safety services, Dr. Faragasso brings to ...
... ... Manufacturing Experience -, SAN DIEGO, May 28 ... Gordon H.,Busenbark to the company,s board of directors. Mr. Busenbark ... privately,held development-stage specialty pharmaceuticals company focused on,diseases of the central ...
... launch of a new collaborative website initially focusing on ... WikiProfessional technology underlying the site has been developed based ... open access journal Genome Biology, WikiProteins provides a method ... The article is written by Barend Mons of the ...
Cached Biology Technology:Premier Research Names Anthony Faragasso, MD as Executive Director and Global Head of Medical Management and Safety 2Nventa Appoints Gordon H. Busenbark to Board of Directors 2Large-scale community protein annotation -- WikiProteins 2
Request Info...
... the optimization of immunostaining. ... the primary antibody, selection and ... Alk. Phos., HRP, fluorescence, or ... evaluation by light or fluorescence ...
Ultra-sensitive, non-radioactive detection of Protein G. Measure Protein G levels quickly and easily....
Request Info...
Biology Products: