Navigation Links
Uranium exposure linked to increased lupus rate
Date:11/13/2012

CINCINNATIPeople living near a former uranium ore processing facility in Ohio are experiencing a higher than average rate of lupus, according a new study conducted by scientists at the University of Cincinnati and Cincinnati Children's Hospital Medical Center.

Lupus is a chronic inflammatory disease that can affect the skin, joints, kidneys, lungs, nervous system and other organs of the body. The underlying causes of lupus are unknown, but it is usually more common in women of child-bearing age.

For this new study, a collaborative team of UC and Cincinnati Children's researchers wanted to compare lupus rates between people who were exposed to uranium and those who were not in an effort to explain the high number of lupus cases reported in a Cincinnati community.

Extensive review of medical records and serum antibody analysis to verify the cases, concluded that people who were exposed to higher levels of uranium, based on their living proximity to a former uranium ore processing plant, had lupus rates four times higher than the average population.

"Former studies have suggested that people with lupus may be more sensitive to radiation and that both genetics and environmental exposures play a role in disease development. Our study shows a strong correlation between uranium exposure, a radioactive substance, and an increased lupus rate that merits further investigation," says Pai-Yue Lu, MD, a pediatric rheumatology fellow at Cincinnati Children's and lead researcher for the study.

"With more research in this area, we may gain additional insight on the types of environmental factors that contribute to lupus development and the mechanisms by which they work," Lu adds. "There could be other effects of uranium and related exposures that could contribute to or help explain our findings."

Lu is presenting this finding and its potential implication at the American College of Rheumatology Annual Scientific Meeting Monday, Nov. 12, in Washington, D.C. She completed the project as part of her master's degree in clinical and translational science training at UC.

The Cincinnati-based team's research is based on nearly two decades of data collected through the Fernald Medical Monitoring Program, the United States' first and largest legally mandated comprehensive medical monitoring program. The program was established in 1990 after a federal investigation revealed that National Lead of Ohio's Feed Materials Production Center in the Hamilton County, Ohio, community of Fernald, was emitting dangerous levels of uranium dust and gases into the surrounding communities.

"The availability of this cohort and carefully collected data and biospecimens provides a great setting to ask research questions," says Susan Pinney, PhD, UC professor of environmental health and principal investigator of the Fernald study.

Almost 10,000 community residents enrolled in the Fernald Medical Monitoring Program. Community residents were classified into several exposure groups: high exposure, moderate exposure, low exposure and no exposure. (Uranium plant workers were not part of this study.)

"Typical U.S. incidence rates for lupus are 1.8 to 7.6 cases per 100,000. Among the 25 confirmed lupus cases we identified through the Fernald community cohort, 12 were in the high exposure group, eight with moderate exposure and five in the low exposure group," says Lu.


'/>"/>
Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati Academic Health Center
Source:Eurekalert

Related biology news :

1. Combined pesticide exposure affects bumblebee colony success
2. New model could help fill data gap in predicting historical air pollution exposure
3. Chemical exposure in the womb from household items may contribute to obesity
4. Tracking the effects of prenatal alcohol exposure through to 9 years of age
5. Socioeconomics may affect toddlers exposure to flame retardants
6. NOAA discovers way to detect low-level exposure to seafood toxin in marine animals
7. Effect of chronic exposure to chemicals used as weapons, pesticides under study
8. Prenatal exposure to air pollution linked to childhood obesity
9. Obese patients face higher radiation exposure from CT scans -- but new technology can help
10. Lower dosage CT-guided lung biopsy protocol maintains quality, minimizes exposure
11. Exposure to antibiotics linked to severity of allergic asthma: UBC research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/5/2017)... 5, 2017 Today HYPR Corp. , ... server component of the HYPR platform is officially ... end-to-end security architecture that empowers biometric authentication across Fortune ... already secured over 15 million users across the financial ... connected home product suites and physical access represent a ...
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/30/2017)... , March 30, 2017 Trends, opportunities and ... and behavioral), by technology (fingerprint, AFIS, iris recognition, facial ... and others), by end use industry (government and law ... financial and banking, and others), and by region ( ... , Asia Pacific , and the ...
Breaking Biology News(10 mins):
(Date:4/26/2017)... ... April 26, 2017 , ... Led by ex-FDA official Peggy ... comes to Tampa, San Francisco and Boston in 2017. The 2016 sold-out ... such as Pfizer Inc., Teva Pharmaceuticals, Advaxis, Inc., Ocular Therapeutix Inc., Cell Culture ...
(Date:4/26/2017)... ... 26, 2017 , ... NextSteps 2017, NetDimensions’ annual global user ... this May on the following dates: , ?    London, UK from May 10-11, ?    New ... and Performance Institute will be the opening keynote speaker at the NextSteps ...
(Date:4/25/2017)... ... April 25, 2017 , ... As part of the Stago EdVantage ... laboratory testing for DIC in order to illuminate this clinical problem for people unfamiliar ... hospitalized patients resulting in a high degree of morbidity and mortality. DIC is a ...
(Date:4/25/2017)... Providence -based biotechnology ... technology to an undisclosed global pharmaceutical company, for ... Tregitopes, pronounced T·rej·itopes, are a set of peptides ... Annie De Groot and EpiVax CIO ... autoimmune disease therapy, Tregitopes are capable of engaging regulatory ...
Breaking Biology Technology: