Navigation Links
Uptake protein acts as zinc's doorway to the cell
Date:11/22/2010

ed. Brookhaven's Jin Chai purified and concentrated the samples before exposing them to zinc. By reconstituting the purified ZIP proteins in this controlled manner, the scientists ensured that their sample would reflect only the ZIP mechanism for cellular zinc uptake.

"It's important to note that people have been trying to purify these proteins for a long time. Purification of the first ZIP family member opens the door for detailed structural and functional analysis at the molecular level," Fu said.

Using a fluorescent indicator, Brookhaven's Wei Lin then conducted several measurements to characterize zinc uptake, with attention to changes in zinc concentration, temperature, acidity, and electric charge.

The Brookhaven team found evidence of electrodiffusion. Ions diffuse by moving from a region with a high concentration to one of a lower concentration like diners who relocate from a crowded dining hall to an adjoining, empty coffee room. In electrodiffusion, the diffused ions also change the electric charge of the space that they occupy. The imbalance in charge created by zinc ions moving into the cell builds during zinc uptake and acts against the concentration gradient, eventually causing zinc uptake to stop.

Based in part on the studies of similar metal-specific proteins, Fu and his colleagues have postulated that the ZIP protein allows zinc ion diffusion by providing an opening that is specifically shaped for zinc coordination chemistry. This hypothesis will eventually be confirmed in studies that crystallize and examine the ZIP protein at the atomic level.

"We are driven by our curiosity we want to know how this works," Fu said.

Aside from satisfying scientific curiosity, this understanding could have a big impact. Zinc uptake at the cellular level is implicated in a range of biomedical and energy research. For example, in green plants, carbonic acid is converted to CO2 in a chemical reaction t
'/>"/>

Contact: Karen McNulty Walsh
kmcnulty@bnl.gov
631-344-8350
DOE/Brookhaven National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New molecular signaling cascade increases glucose uptake
2. Modulating a protein in the brain could help control Alzheimers disease
3. Process leading to protein diversity in cells important for proper neuron firing
4. A stem cell secreted protein can be given to improve heart function after experimental heart attack
5. Structure of a protein related to heart and nervous system health revealed
6. Synapses recycle proteins for the release of neurotransmitters
7. Prima donna protein doesnt work well in pairs
8. Scientists at IRB Barcelona discover a new protein critical for mitochondria
9. X-ray crystallography reveals structure of precursor to blood-clotting protein
10. Chemists concoct new agents to easily study critical cell proteins
11. Scripps Research team watches formation of cells protein factories for first time
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Janeiro, Brazil- In the brains of all vertebrates, ... allows an electric or chemical signal to be ... synapses, which are the most abundant type of ... formation is crucial for learning, memory, perception and ... synapses critical for brain function. For instance, ...
(Date:7/10/2014)... 2014 Smart technology emphasis grows in ... improved security: NXT-ID, Inc. (OTCBB: NXTD), eBay Inc. (NASDAQ: ... Apple Inc. (NASDAQ: AAPL ), Visa Inc. (NYSE: ... NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on ... second series of 30 second spots on CNBC for its ...
(Date:7/10/2014)... , July 3, 2014 Research and ... of the "Global Gesture Recognition & Touch-Less ... Forecasts to 2020" report to their offering ... Global Gesture Recognition & Touch-Less Sensing Market to ... for a while, but the companies were unable ...
Breaking Biology News(10 mins):Blame it on the astrocytes 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 2Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 3Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 4Advantages for Digital Wallets Eliminate Need to Carry Credit Cards - Large Scale CNBC Ad Campaign for Latest Smart Wallet to Commence July 7th 5Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... A more accurate method for measuring blood levels of ... damage to the arterial lining has been discovered by ... endothelial progenitor cells (EPC), are produced in the bone ... , The researchers said that tests for EPCs could ...
... spreading at an alarming rate throughout Britain's coast and ... mitten crab, brought to Britain during the last century ... if populations are not monitored and controlled, say the ... Newcastle upon Tyne carried out the first comprehensive modelling ...
... State University of New Jersey, believe they have located ... memories of their parents' songs. The discovery has implications ... few animals that learn to vocalize by imitating their ... Proceedings of the National Academy of Sciences, David Vicario ...
Cached Biology News:Measuring artery repair cells could become new heart disease test 2Measuring artery repair cells could become new heart disease test 3Exotic crab poised for widespread UK invasion 2Exotic crab poised for widespread UK invasion 3Zebra finches remember songs dad sang 2Zebra finches remember songs dad sang 3
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... assembling a club sandwich at the nanoscale, National ... succeeded in crafting a uniform, multi-walled carbon-nanotube-based coating ... used in upholstered furniture and other soft furnishings. ... was reduced 35 percent compared with untreated foam. ...
(Date:1/15/2014)... Ill. , Jan. 15, 2014  Bill Jacobs Automotive, a ... , is teaming up with the Heartland Blood Center and ... blood drive. The drive takes place Saturday, Jan. 18 at ... - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... 2014   Niagara Thermal Products is proud to ... Technologies LLC ("B3") as the critical thermal component supplier ... the Army Corps of Engineers.  B3 has developed the ... contaminants and destroys VOCs and other chemical pollutants, allergens ...
Breaking Biology Technology:University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... , HOUSTON, Dec. 3 ... updated its facility to offer patients a second surgical option, ... that it currently performs. The first sleeve gastrectomy procedure at the ... on October 20, 2009. The patient is reported as doing ...
... , PHILADELPHIA, Dec. 3 Shire plc ... company, today announced a voluntary recall of five lots and ... (ADHD) patch Daytrana ® . Shire is taking this action ... future may not meet their release liner removal specification, and ...
... , ... Dr. Susan Jiang, M.D., Ph.D.,Chief Science Officer at Shenzhen Beike Biotechnology ... Diabetic,Foot Care in New Delhi, India, November 22, 2009. Beike is ... The conference, organized by the Indian Podiatry Association (IPA), ...
Cached Biology Technology:JourneyLite of Houston Now Offering Sleeve Gastrectomy 2Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 2Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 3Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 4Non-safety-related voluntary recall of a limited portion of Daytrana(R) (methylphenidate transdermal system) patches announced 5Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 2Beike Biotechnology CSO Speaks on Role of Stem Cells in Treating Diabetic Foot Disease at IPA Diabetic Foot Care Conference, India 3
mu Opioid Receptor splice variant Immunogen: Synthetic peptide corresponding to residues K S C M D R G M R N L L P D D G P R Q E of Mu Opioid Receptor. Storage: -20 C, Avoid Freeze/Thaw Cycle...
Anti-Salmonid Ig (H), Alk Phos, (Clone IPA5F12) (mouse IgG2a)...
Rat monoclonal [HK5.3] to B7 RP1 (Phycoerythrin) ( Abpromise for all tested applications). entrezGeneID: 23308 SwissProtID: O75144...
... with the HECT protein, E6-AP ... Evidence suggests that this E2 ... degradation of non-""N-end rule"" protein ... -acetylated proteins as well as ...
Biology Products: