Navigation Links
Updated formula measures kidney function more accurately
Date:2/24/2009

Measuring kidney function in children can be expensive, time-consuming for clinicians, and tedious for children, who may be exposed to radioactivity and subjected to a large number of blood draws. A new calculation eliminates many of these obstacles, relying instead on various blood tests that can be performed in a clinical setting to offer an accurate estimate of a child's kidney function.

This new estimate formula, developed from a study that will appear in the Journal of the American Society of Nephrology in March, could prove a valuable tool for adjusting fluids, antibiotics and chemotherapy and more accurately assessing kidney function in children battling chronic kidney disease (CKD). This formula can be used to estimate glomerular filtration rate (GFR) the rate at which fluid is filtered through the kidneys quickly and without infusing any synthetic substances. It was developed from a multi-site NIH-funded study for which the University of Rochester serves as the central biochemistry laboratory.

"Most other formulas used to estimate kidney function in children with CKD are singular to their institutions or hospitals. In addition, most clinicians are unaware of what biochemical analyses are being used by their institutions to measure waste products excreted by the kidney, such as creatinine and blood urea nitrogen (BUN), and different analyses would yield different estimate formulas," said George J. Schwartz, M.D., chief of Pediatric Nephrology at the University of Rochester Medical Center's Golisano Children's Hospital at Strong and director of University of Rochester's biochemistry lab. "An accurate estimate is crucial to properly treat children with acute and chronic kidney problems and the scale of this study makes its findings quite significant."

The study included 349 patients from more than 50 institutions across North America and was based on data collected by the CKiD Study, which was funded by the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health. Schwartz is a principal investigator in the Chronic Kidney Disease in Children (CKiD) Cohort Study.

The new GFR formula generated by the study is based on height and gender, serum creatinine and BUN, and cystatin C a ubiquitous protein that is well-correlated with kidney function. These factors can be quickly and easily measured in a clinical setting without the need for radioactivity or urine collection.

"Clinicians can easily specify the gender and height of a child during a regular clinical visit. A basic chemistry panel on a very small sample of blood will determine the level of serum creatinine and BUN, while a slightly more complicated method of collection will yield the cystatin C result. These five variables can effectively assess how well a child's kidney functions," said Schwartz. In addition, the study developed a quick bedside calculation that offers a good approximation of the GFR formula from the child's height in centimeters, serum creatinine level and a constant that relates this estimate to the measured level of GFR.

The new Schwartz formula uses an updated method of measuring creatinine. The enzymatic analysis can measure creatinine much more accurately than the older Jaffe method, which utilized a less specific color change. The Jaffe method was used in an earlier estimated GFR formula that Schwartz developed in the mid-1970s.

The study focused on finding a more precise GFR estimate formula for children with CKD because chronic kidney disease does not go away and tends to worsen over time, eventually resulting in kidney failure.

"Because children with CKD are more in danger of progressing to kidney failure than children with normal kidney function, we decided it was imperative to find an accurate estimate of GFR for children with CKD before studying other populations," said Schwartz.. "It will also be important to determine if such a formula will apply to children and infants with higher levels of kidney function, so that any harm that might come from antibiotics, chemotherapeutic drugs and dehydration can be minimized in these populations as well."


'/>"/>

Contact: Katie Sauer
Katie_Sauer@URMC.rochester.edu
585-276-4298
University of Rochester Medical Center
Source:Eurekalert

Related biology news :

1. Biochemistry of human physiology in health and disease is focus of updated clinical text
2. New infant formula safety advice could prevent infant suffering
3. UBC study establishes formula for predicting climate change impact on salmon stocks
4. Link possible between pet food contamination and baby formula contamination
5. Formula discovered for longer plant life
6. Researchers study facial structures, brain abnormalities to reveal formula for detection of autism
7. Louisiana Tech researchers feature drug reformulation in prestigious journal
8. New formula for combating the greenhouse gas nitrous oxide
9. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
10. Ecologists report quantifiable measures of natures services to humans
11. NIAID announces 25 new awards to develop radiation countermeasures
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2016)... -- Cercacor today introduced Ember TM Sport Premium ... measure hemoglobin, Oxygen Content, Oxygen Saturation, Perfusion Index, ... approximately 30 seconds. Smaller than a smartphone, using only ... key data about their bodies to help monitor these ... Hemoglobin carries oxygen to muscles. When hemoglobin and ...
(Date:11/19/2016)... Securus Technologies, a leading provider of civil ... corrections and monitoring, announced today that it has offered ... an independent technology judge determine who has the largest ... telephone calling platform, and the best customer service. ... of what we do – which clearly is not ...
(Date:11/15/2016)... ROCKVILLE, Md. , Nov. 15, 2016 /PRNewswire/ ... clinical company developing therapeutics focused on the gut ... public offering of 25,000,000 shares of its common ... its common stock at a price to the ... gross proceeds to Synthetic Biologics from the offering, ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... (PRWEB) , ... December 02, ... ... (ETC), a consortium of pharmaceutical and biotechnology companies dedicated to collaboratively developing ... companies interested in supplying a vendor-supported, portable online UHPLC, with robust, probe-based ...
(Date:12/2/2016)... , December 2, 2016 The ... 2021, growing at a CAGR of 7.3% during the forecast period ... hospitals and diagnostic laboratories segment accounted for the largest share of ... ... report on global immunohistochemistry (IHC) market spread across 225 pages, profiling ...
(Date:11/30/2016)... 30, 2016  GenomOncology today announced the appointment of ... Affairs.  Dr. Coleman will oversee clinical content ... knowledge-enabled platform. The GenomOncology software suite empowers molecular pathologists with ... and clinical decision support, from quality control through reporting. ... , , ...
(Date:11/30/2016)... 2016 Biotest Pharmaceuticals Corporation (BPC), a leading ... the addition of its newest plasma collection center located ... . The 15,200 square foot state-of-the-art facility officially opened ... brings the total number of BPC,s plasma collection centers ... BPC,s Chief Executive Officer said "We are pleased to ...
Breaking Biology Technology: