Navigation Links
UofL scientist uncovers how airway cells regenerate after chlorine gas injury
Date:12/19/2012

LOUISVILLE, Ky. - Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

University of Louisville scientist Gary Hoyle, Ph.D., School of Public Health and Information Sciences Department of Environmental and Occupational Health Sciences, and his team have uncovered new clues in understanding how epithelial cells - the cells that line the trachea, bronchi and other airways that carry air in and out of the lung - repair themselves after chlorine gas exposure. The findings were recently published in the American Journal of Physiology Lung Cellular and Molecular Physiology in the article, Differential Susceptibility of Inbred Mouse Strains to Chlorine-Induced Airway Fibrosis. The research is funded by the National Institutes of Health (NIH) CounterACT program.

"The repair of injured epithelial cells is necessary to restore normal lung structure and function," Hoyle said. "The goal is to prevent scarring or fibrosis in the airways. It is a race between new epithelial cell growth and scar tissue development, and it takes about five to seven days after chlorine exposure for that to begin."

Following chlorine-related injury, Hoyle found that a type of epithelial cells called basal cells initiated the repair and served as progenitor cells early descendants of stem cells that can differentiate to form one or more cell types. The progenitor cells helped restore new tissue in the airways.

"Structural changes in the respiratory system are difficult to reverse, so understanding how cells function and multiply can help us develop treatments to prevent scarring and subsequent asthma-like breathing problems that affect for a life time some people who've experienced high levels of chlorine exposure," Hoyle said.

This type of lung injury also can be caused by other types of industrial chemicals including ammonia, methylisocyanate and sulfur dioxide.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
2. Chinese scientists discover evidence of giant pandas population history and local adaptation
3. Scientists develop novel method to study parasite numbers in wild seabirds
4. Was the sauropod dinosaurs large size due to plant food? Scientists argue old idea still has legs
5. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
6. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
7. UC Riverside entomologist named Distinguished Scientist of the Year
8. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
9. New test adds to scientists understanding of Earths history, resources
10. WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation
11. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... , Dec. 15, 2016   WaferGen Bio-systems, Inc. ... genomics technology company, announced today that on December 13, ... Department of The Nasdaq Stock Market LLC which acknowledged ... price of WaferGen,s common stock had been at $1.00 ... has regained compliance with Listing Rule 5550(a)(2) of the ...
(Date:12/15/2016)... , Dec. 14, 2016 "Increase in ... biometrics market" The mobile biometrics market is expected to ... 49.33 billion by 2022, at a CAGR of 29.3% ... factors such as the growing demand for smart devices, ... transactions. "Software component is expected to grow ...
(Date:12/7/2016)... According to a new market research report "Emotion Detection and Recognition Market ... Application Area, End User, And Region - Global Forecast to 2021", published by ... 2016 to USD 36.07 Billion by 2021, at a Compound Annual Growth Rate ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:1/20/2017)... 20, 2017 Stock-Callers.com explores the ... influenced the most recent performances of select equities. In ... RGLS ), Abeona Therapeutics Inc. (NASDAQ: ... ), and Sage Therapeutics Inc. (NASDAQ: SAGE ... View Research, global Biotech market size is expected to reach $604.40 billion by ...
(Date:1/19/2017)... Jan 19, 2017 Research and Markets has ... Technology, Biomolecules, Cancer Type, Application - Global Opportunity Analysis and Industry ... ... the global market is projected to reach $15,737 million by 2022 ... 2016 to 2022. Omic technologies segment accounted for ...
(Date:1/19/2017)... Research and Markets ... announced the addition of the "Implantable Biomaterials Market ... report to their offering. Report Highlights: ... analysis on current and future market trends to identify the investment opportunities ... the base numbers Key market trends across the business ...
(Date:1/19/2017)... 19, 2017  ArmaGen, Inc., today announced that ... as chief executive officer, as well as a ... to ArmaGen more than 17 years of executive ... of biotherapeutics and pharmaceuticals. "Mathias ... experience and skillset necessary to lead ArmaGen to ...
Breaking Biology Technology: