Navigation Links
UofL scientist uncovers how airway cells regenerate after chlorine gas injury
Date:12/19/2012

LOUISVILLE, Ky. - Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

University of Louisville scientist Gary Hoyle, Ph.D., School of Public Health and Information Sciences Department of Environmental and Occupational Health Sciences, and his team have uncovered new clues in understanding how epithelial cells - the cells that line the trachea, bronchi and other airways that carry air in and out of the lung - repair themselves after chlorine gas exposure. The findings were recently published in the American Journal of Physiology Lung Cellular and Molecular Physiology in the article, Differential Susceptibility of Inbred Mouse Strains to Chlorine-Induced Airway Fibrosis. The research is funded by the National Institutes of Health (NIH) CounterACT program.

"The repair of injured epithelial cells is necessary to restore normal lung structure and function," Hoyle said. "The goal is to prevent scarring or fibrosis in the airways. It is a race between new epithelial cell growth and scar tissue development, and it takes about five to seven days after chlorine exposure for that to begin."

Following chlorine-related injury, Hoyle found that a type of epithelial cells called basal cells initiated the repair and served as progenitor cells early descendants of stem cells that can differentiate to form one or more cell types. The progenitor cells helped restore new tissue in the airways.

"Structural changes in the respiratory system are difficult to reverse, so understanding how cells function and multiply can help us develop treatments to prevent scarring and subsequent asthma-like breathing problems that affect for a life time some people who've experienced high levels of chlorine exposure," Hoyle said.

This type of lung injury also can be caused by other types of industrial chemicals including ammonia, methylisocyanate and sulfur dioxide.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
2. Chinese scientists discover evidence of giant pandas population history and local adaptation
3. Scientists develop novel method to study parasite numbers in wild seabirds
4. Was the sauropod dinosaurs large size due to plant food? Scientists argue old idea still has legs
5. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
6. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
7. UC Riverside entomologist named Distinguished Scientist of the Year
8. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
9. New test adds to scientists understanding of Earths history, resources
10. WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation
11. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/29/2016)... 29, 2016 BioDirection, a privately held medical ... the objective detection of concussion and other traumatic brain ... completed a meeting with the U.S. Food and Drug ... Pre-Submission Package. During the meeting company representatives reviewed plans ... precursor to commencement of a planned pilot trial. ...
(Date:11/28/2016)... "The biometric system market projected to ... system market is in the growth stage and is ... biometric system market is expected to be valued at ... 16.79% between 2016 and 2022. Government initiative in adoption ... rising use of biometric technology in financial institutes and ...
(Date:11/22/2016)... --  MedNet Solutions , an innovative SaaS-based eClinical technology ... is pleased to announce that the company has been ... Awards as "Most Outstanding in eClinical Solutions" for ... recognition and growth for MedNet, which has effectively supported ... iMedNet ™ , MedNet,s flagship eClinical technology ...
Breaking Biology News(10 mins):
(Date:12/7/2016)... 7, 2016 Neogen Corporation (NASDAQ: ... Dan Kephart as its chief science officer — ... his responsibilities at Neogen effective Jan. 1. ... the agribusiness unit of Thermo Fisher Scientific, as well ... Technologies. His extensive industry experience also includes the management ...
(Date:12/7/2016)... SAN DIEGO , Dec. 7, 2016  Biocom, the ... community, issued the statement below following passage of 21 st ... the House on November 30 by a 392-26 vote and ... This statement may be attributed to Joe Panetta , ... historic legislation that will give hope to millions of patients ...
(Date:12/7/2016)... 7, 2016  Muse bio, a privately-held company leading ... that Dr. Kevin Ness has been appointed ... Directors. Kevin succeeds Muse bio,s founding ... Chief Science Officer as well as remains Slade Professor, ... BioDesign Center at the RAS Energy Institute at the ...
(Date:12/7/2016)... , ... December 07, 2016 , ... ... pathology, announced today a new service to enable rapid migration of large pathology ... has remained one of the factors limiting adoption of digital pathology. Proscia’s free ...
Breaking Biology Technology: