Navigation Links
UofL scientist uncovers how airway cells regenerate after chlorine gas injury
Date:12/19/2012

LOUISVILLE, Ky. - Scarring of the airways can lead to long-term breathing problems for some people exposed to high levels of chlorine gas from events such as an industrial accident, chemical spill following a train derailment or terroristic chemical warfare. Household mishaps from mixing bleach with acidic cleaning products also can cause release of chlorine gas; if this occurs in a poorly ventilated space, chlorine levels could be high enough to cause lung injury.

University of Louisville scientist Gary Hoyle, Ph.D., School of Public Health and Information Sciences Department of Environmental and Occupational Health Sciences, and his team have uncovered new clues in understanding how epithelial cells - the cells that line the trachea, bronchi and other airways that carry air in and out of the lung - repair themselves after chlorine gas exposure. The findings were recently published in the American Journal of Physiology Lung Cellular and Molecular Physiology in the article, Differential Susceptibility of Inbred Mouse Strains to Chlorine-Induced Airway Fibrosis. The research is funded by the National Institutes of Health (NIH) CounterACT program.

"The repair of injured epithelial cells is necessary to restore normal lung structure and function," Hoyle said. "The goal is to prevent scarring or fibrosis in the airways. It is a race between new epithelial cell growth and scar tissue development, and it takes about five to seven days after chlorine exposure for that to begin."

Following chlorine-related injury, Hoyle found that a type of epithelial cells called basal cells initiated the repair and served as progenitor cells early descendants of stem cells that can differentiate to form one or more cell types. The progenitor cells helped restore new tissue in the airways.

"Structural changes in the respiratory system are difficult to reverse, so understanding how cells function and multiply can help us develop treatments to prevent scarring and subsequent asthma-like breathing problems that affect for a life time some people who've experienced high levels of chlorine exposure," Hoyle said.

This type of lung injury also can be caused by other types of industrial chemicals including ammonia, methylisocyanate and sulfur dioxide.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
2. Chinese scientists discover evidence of giant pandas population history and local adaptation
3. Scientists develop novel method to study parasite numbers in wild seabirds
4. Was the sauropod dinosaurs large size due to plant food? Scientists argue old idea still has legs
5. Another muscular dystrophy mystery solved; MU scientists inch closer to a therapy for patients
6. Gladstone scientists discover novel mechanism by which calorie restriction influences longevity
7. UC Riverside entomologist named Distinguished Scientist of the Year
8. Neuroscientists prove ultrasound can be tweaked to stimulate different sensations
9. New test adds to scientists understanding of Earths history, resources
10. WHOI scientist receives marine microbiology initiative investigator award from Moore Foundation
11. 23andMe scientists receive more than $500,000 in National Institutes of Health funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... NEW YORK , March 2, 2017 Summary ... to better understand Perrigo and its partnering interests and activities ... ... The Partnering Deals and Alliance since 2010 report provides an ... world,s leading life sciences companies. On demand company ...
(Date:3/1/2017)... 2017  Aware, Inc. (NASDAQ: AWRE), a leading supplier ... P. Moberg has resigned, effective March 3, 2017, ... Officer and Treasurer of Aware citing a desire to ... member of the Board of Directors of Aware. ... Officer and co-President, General Counsel has been named Chief ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... New York , March 22, 2017 ... is largely fragmented, states a research report by Transparency ... S.A., Pfizer Inc., Amgen Inc., and AbbVie Inc., accounted ... in 2015. The prominent players in this market are ... expand their product portfolio, which is likely to lead ...
(Date:3/22/2017)... , March 22, 2017 /PRNewswire/ - FACIT announced ... "Company" or "Propellon"), a start-up created by FACIT ... therapeutics. FACIT,s investment, combined with non-dilutive capital, achieves ... The seed funding enables Propellon to accelerate the ... Company for financing and/or entering a strategic partnership ...
(Date:3/22/2017)... 22, 2017   VWR (NASDAQ: ... product and service solutions to laboratory and ... acquired EPL Archives, Inc., an international biorepository ... entire regulated product research, development and commercialization ... and ancillary services. EPL Archives is widely ...
(Date:3/22/2017)... ... ... Okyanos Cell Therapy has announced Tallahassee, FL will be the next destination ... Therapy: The Next Phase in the Evolution of Medicine.” As the Bahamas’ first fully ... Act, Okyanos maintains a mission to help “no-option” patients and those with serious, ...
Breaking Biology Technology: