Navigation Links
UofL researcher determines how Legionnaires' bacteria proliferate, cause disease
Date:11/17/2011

process occurs in a host animal or human who inhales the bacterium and is diagnosed with Legionnaires' disease. However, the bacteria do not tag the proteins, but rather trick the host into tagging the proteins for degradation to generate the amino acids.

In the laboratory, Abu Kwaik and his team saw that by inactivating the bacterial virulence factor responsible for tricking the cell into tagging proteins for degradation in mice models, the pulmonary disease was totally prevented. This was totally due to disabling the bacteria from generating amino acids, he said.

The process was then reversed, and the disease became evident when the mice, infected by the disabled bacteria, were injected with amino acids to compensate for the inability of the altered bacteria.

"Bacteria need to live on high protein and amino acids as sources of nutrition and energy in order to replicate in a host. This is what causes pulmonary disease," Abu Kwaik said. "No one has known how they generate sufficient sources of nutrients from the host to proliferate. Our work is the first to identify this process for any bacteria that cause disease."

He added that the type of host infected does not appear to affect the process. "Whether in a single-cell amoeba or a multi-cellular mammal, Legionella seems to know what to do; the process is the same, and is highly conserved through evolution. By interfering with the bacterium's sources of nutrients, we can stop it from thriving and causing disease."

Examining nutrient sources for organisms with the goal of stopping them from acquiring nutrients is a relatively new arena of basic research that deserves further study, he said. "We went after the basics the food and energy source which are prerequisite for the bacteria to grow and cause disease. It is not a process that is well understood yet, but by first discovering how an organism gets nutrients by tricking the host into degrading proteins, and then in
'/>"/>

Contact: Jill Scoggins
jill.scoggins@louisville.edu
502-852-7461
University of Louisville
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Smart swarms of bacteria inspire robotics researchers
2. Finnish researchers discover regulator of human cell activity
3. MSU researcher sent to Siberia to study global change
4. Rutgers-Camden researcher examines how the brain perceives shades of gray
5. USC researchers discover key aspect of process that activates breast cancer genes
6. Researchers confirm new cancer-causing virus
7. Researchers get $7.5M grant to combat nerve agents
8. Researchers uncover why the body cant defend against tuberculosis
9. Results triple researchers projections with use of adult stem cells for heart failure
10. Researchers develop more effective way to discover and test potential cancer drugs
11. Researchers closer to the super bug puzzle
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... , April 14, 2015  HYPR Corp. ... Online (FIDO ® ) Alliance tm , an ... FIDO members commit to share technology and collaborate ... that are interoperable, more secure and private, and ... biometric identity verification that protects sensitive user information ...
(Date:4/13/2015)... , April 13, 2015 ... TechSci Research, "Global Biometrics Market Forecast & Opportunities, 2020", ... a CAGR of around 14% till 2020. The ... for large scale implementation and review of biometric ... launch of new products with greater efficiency, are ...
(Date:4/10/2015)... Research and Markets ( http://www.researchandmarkets.com/research/cjk4gb/security ... Competitive Profiles - NEC" report to their offering. ... will continue to supply a range of IT security ... company focus on the development of a Big Data ... in the Asia-Pacific region is ...
Breaking Biology News(10 mins):HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NEC Security Competitive Profile 2015 2
... for alternative ,medicines, and luxury goods in Asian markets, ... being invested in enforcement, while events such as China,s ... problem. However, research in Conservation Letters ... the ,War on Drugs, as they lack a long-term ...
... of Visualized Experiments , published a modern approach to ... intriguing research questions facing scientists todaythe origin of life ... is comprised of a modern and simplified approach to ... Harold Urey in 1953. Their research evaluated the possibility ...
... air pollution blowing across the Pacific Ocean is often caused ... and Europe, according to findings by UC Irvine and other ... Academy of Sciences . The study is the first ... is from the production in China of cellphones, televisions and ...
Cached Biology News:A 21st century adaptation of the Miller-Urey origin of life experiments 2Made in China for us: Air pollution tied to exports 2
(Date:6/3/2015)... REYKJAVIK, Iceland , June 3, 2015   ... genome to improve health worldwide, today announced that it ... to provide clinical interpretation of the whole genome sequences ... of the first phase of the 100,000 Genomes Project ... WuXi NextCODE will deploy its unique database ...
(Date:6/3/2015)... 2015 Marktech Optoelectronics is pleased to ... APD’s have an internal gain mechanism, fast time response, ... infrared region. These APD’s are recommended for applications that ... to overcome high pre-amp noise. In addition, Marktech APD's ... ideal for extreme low-level light detection and short pulse ...
(Date:6/3/2015)... (PRWEB) June 03, 2015 GEA's ... , which is a standalone, fully-equipped laboratory unit that ... for limited productions in pilot plants. The Panther™ NS3006L ... its compact design allows for easy installation with simple ... products. This homogenizer can be used in many different ...
(Date:6/3/2015)... June 03, 2015 From smart street ... important part in enabling success in dealing with important ... technology leaders helped bring focus to the role and ... Photonics21 annual meeting last week in Brussels. ... event, held 28 and 29 May at the Hotel ...
Breaking Biology Technology:WuXi NextCODE Wins Genomics England Clinical Interpretation Tender in both Rare Disease and Cancer 2Marktech Introduces New Line of APDs 2GEA Announces the Panther™ NS3006L, a Self-Contained, Fully-Equipped Laboratory Homogenizer Well Suited for Pilot Plants 2Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 2Photonics21 Annual Meeting Focuses on Solutions for ‘Societal Challenges’ 3
... taskforce of forest industry,stakeholders from Eastern Canada ... bio-related opportunities within the forestry sector across ... is comprised of regional government,industry, federal and ... has come together to better understand what,opportunities ...
... the Ferring Research,Infertility and Gynaecology GrAnt (FRIGGA) are ... & Embryology Congress. The two,winners of this new ... and the Universitair Ziekenhuis (UZ) Brussel, Centre for,Reproductive ... for their outstanding,proposals for fundamental research to help ...
... 7 Neurobiological,Technologies, Inc. (NTI(R)) (Nasdaq: NTII ), ... officer (CEO), has announced his,intent to retire on December ... serve on the Board. Mr. Freiman is the former ... Mr. Freiman is retiring after 11 years of ...
Cached Biology Technology:Atlantica BioEnergy Task Force Unveiled 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 2Ferring Research Infertility and Gynaecology GrAnt (FRIGGA) 2008 Winners Announced 3Neurobiological Technologies' CEO to Retire on December 31, 2008 2
Request Info...
384 Cluster Tube Racks...
Request Info...
Unique enzyme blend containing Taq and Pwo DNA Polymerase and another thermostable enzyme. The Expand 20 kbPLUS PCR System also includes an optimized reaction buffer, MgCl2 solution, and a human cont...
Biology Products: