Navigation Links
UofL researcher awarded $2.6 million NIH grant renewal
Date:10/12/2011

Gary Hoyle, PhD, professor, University of Louisville School of Public Health and Information Sciences, will build on his research to develop an effective medical treatment to counteract chlorine-induced lung injuries caused by chemical accidents or acts of terrorism. The National Institute of Environmental Health Sciences and the Office of the Director of the NIH have awarded Hoyle $2.6 million over five-years to further his research initially funded in 2006.

Hoyle and his team have identified two medical treatments rolipram and triptolide - that show promise of treating lung injury from chlorine, a reactive gas highly toxic by inhalation. Rolipram helps with impaired lung function and pulmonary edema where fluid gets into the lungs, leading to a shortness of breath. This medication does not affect inflammation. Triptolide, a natural plant product used in traditional Chinese medicine, prevents chlorine-induced lung inflammation but has no effects on other aspects of lung injury.

"We believe an intramuscular injection of rolipram in combination with an anti-inflammatory will represent the most effective countermeasure for chlorine-induced lung injury," Hoyle said. "It is important that we develop a medical treatment that can be administered quickly to large numbers of patients by first responders or personnel with limited medical training."

The formulations will be developed by the Southwest Research Institute (SwRI) and evaluated for effectiveness at the University of Louisville. Kenneth Carson, PhD, is leading the formulation effort at (SwRI). Andrew Roberts, PhD, UofL, and Roy Rando, ScD, Tulane University, will work with Hoyle on evaluation of the compounds.

"The countermeasures we are developing target aspects of lung injury that are not unique to chlorine exposure, but are also observed after inhalation of other chemical agents such as phosgene, ammonia, sulfur mustard, and smoke.

"This research has the potent
'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Page: 1 2

Related biology news :

1. Medical College of Wisconsin researchers show molecule inhibits metastasis
2. Researchers study agings effect on the brain
3. Notre Dame researchers report progress on compound to treat neurological diseases
4. UNH researchers: Multibeam sonar can map undersea gas seeps
5. Chagas disease may be a threat in South Texas, says researcher
6. Researchers realize high-power, narrowband terahertz source at room temperature
7. Researchers: Apply public trust doctrine to rescue wildlife from politics
8. Dead Sea researchers discover freshwater springs and numerous micro-organisms
9. Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say
10. LSU researchers find impact of oil spill in marsh fish species
11. MU researchers find new insight into fatal spinal disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2014)... Utah , Dec. 4, 2014  Tute Genomics, ... raised $2.3 million in Series A1 funding led by ... investors also participated in the investment round. ... the healthcare community adopts next-generation sequencing and seeks new ... said Reid Robison , MD MBA, and CEO ...
(Date:12/3/2014)... , Dec. 2, 2014   Marvin Test ... innovative test solutions for military, aerospace, and manufacturing ... of its successful TS-900 PXI semiconductor test ... features of high-end systems to customers at a ... compared to traditional ATE. "Our ...
(Date:11/21/2014)... November 18, 2014 According to ... by Systems (Video, RFID, Access Control, Intrusion Detection, Parking ... Banks, Government), Component Service Geography - Global Forecasts to ... is projected to be around $25 Billion in 2014 ... growing at a CAGR of 8.69%. Browse ...
Breaking Biology News(10 mins):Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 2Tute Genomics Raises $2.3 Million to Scale Up Cloud-Based Genome Analytics and Accelerate Personalized Medicine 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3
... for drinking water but about 20 years ago the once ... toxic blue-green algae which can damage the liver, intestines and ... Knoxville, will be working on an international team funded by ... resolve the ecosystem balance in the lake. Their work could ...
... This press release is available in Spanish . ... scientist has found a "green" alternative to a type ... the accumulation of heavy metals in waterways. Ornamental ... copper and zinc. But fertilizers that provide these micronutrients ...
... dietary fats are not created equal. Some types of fats have ... like those often found in plants and fish, have well documented ... destructively to some fats but not others? A new ... Biology suggests the answer may lie in how different fats ...
Cached Biology News:University of Tennessee Team receives NSF support to study toxic water in China 2A greener way to fertilize nursery crops 2The Quarterly Review of Biology: Why some fats are worse than others 2
(Date:12/19/2014)... (PRWEB) December 18, 2014 Today, ... locate its pilot production facility and future company ... and produce innovative new materials that safely and ... not only because of its historic, strong support ... efforts to attract leading edge, technology-based companies such ...
(Date:12/19/2014)... In contrast to traditional LED lights where ... Valoya uses proprietary LED technology to incorporate their spectra ... which is critical in low proximity installations. The Valoya ... its lifetime which is up to four times longer ... investment cost was clearly higher when compared to traditional ...
(Date:12/19/2014)... , Dec. 18, 2014   ISN has ... Safety Performance Indicators publication series. With data ... activity reported in 2013 within its online contractor management ... safety key performance indicator (KPI) statistics. ... U.S. publication is available in two industry ...
(Date:12/17/2014)... Houston, TX (PRWEB) December 17, 2014 ... marketing and administration for Stoller Group. In this position, ... Stoller Group, on administrative matters, develop marketing strategy and ... and services. , “Achim has tremendous knowledge and ... president of Stoller Group. “His experience and innovative thinking ...
Breaking Biology Technology:Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 2Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 3Technology Company TiFiber™ to Establish Production Facility in Fort Smith, Arkansas with Support from Local Investors 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... to innovation, American Family Insurance's Information Services Division ... The direction comes from within, and Byrne Chapman, vice president ... familiar phrase: nothing ventured, nothing gained. To build a culture ... modeled after employee-driven, quality-control programs. , ,While management experts ...
... plans to erect as many as five more buildings on ... about needs well beyond its existing base of 2,500 employees, ... administrative officer, said the company anticipates adding 1,500 more individual ... 2,500. In addition, there remains plenty of room on the ...
... protection firms could be the answer to a question you ... ,The Internet does connect you with your customers - and ... that could damage your reputation and sales. Here are several ... simple to the sophisticated, and suggestions for dealing with them. ...
Cached Biology Technology:CIO Leadership Series: Byrne Chapman, American Family Insurance 2CIO Leadership Series: Byrne Chapman, American Family Insurance 3CIO Leadership Series: Byrne Chapman, American Family Insurance 4Epic Systems will build well beyond current staff size 2Protecting your business against online brand abuse 2Protecting your business against online brand abuse 3
SDS-OutT Precipitation Reagent...
... Removal , , Removes ... cross-reactivity with other proteins , Simple, just ... Economical new surface technology, not based on ... with protein analysis. SurfactAway offers a simple ...
... speed and excellent temperature uniformity. Protocols that ... can be run without any modifications. The ... for 48 or 96 wells. In addition, ... applications are available. The High Precision Smart ...
General description: MaxiSorp TM surface is ideal for arraying molecules with mixed hydrophilic/hydrophobic domains such as proteins ID clarifier: Maxisorp(tm) with lid...
Biology Products: