Navigation Links
UofL researcher awarded $2.6 million NIH grant renewal
Date:10/12/2011

Gary Hoyle, PhD, professor, University of Louisville School of Public Health and Information Sciences, will build on his research to develop an effective medical treatment to counteract chlorine-induced lung injuries caused by chemical accidents or acts of terrorism. The National Institute of Environmental Health Sciences and the Office of the Director of the NIH have awarded Hoyle $2.6 million over five-years to further his research initially funded in 2006.

Hoyle and his team have identified two medical treatments rolipram and triptolide - that show promise of treating lung injury from chlorine, a reactive gas highly toxic by inhalation. Rolipram helps with impaired lung function and pulmonary edema where fluid gets into the lungs, leading to a shortness of breath. This medication does not affect inflammation. Triptolide, a natural plant product used in traditional Chinese medicine, prevents chlorine-induced lung inflammation but has no effects on other aspects of lung injury.

"We believe an intramuscular injection of rolipram in combination with an anti-inflammatory will represent the most effective countermeasure for chlorine-induced lung injury," Hoyle said. "It is important that we develop a medical treatment that can be administered quickly to large numbers of patients by first responders or personnel with limited medical training."

The formulations will be developed by the Southwest Research Institute (SwRI) and evaluated for effectiveness at the University of Louisville. Kenneth Carson, PhD, is leading the formulation effort at (SwRI). Andrew Roberts, PhD, UofL, and Roy Rando, ScD, Tulane University, will work with Hoyle on evaluation of the compounds.

"The countermeasures we are developing target aspects of lung injury that are not unique to chlorine exposure, but are also observed after inhalation of other chemical agents such as phosgene, ammonia, sulfur mustard, and smoke.

"This research has the potential to develop broad spectrum therapies that could be used against multiple types of chemical threat agents," Hoyle said.

Chlorine is considered a chemical threat because of the large amounts that are produced and transported in the United States, its ready availability and its toxicity.

The gas is used in a variety of industrial processes, including the production of plastics, solvents, paper products, and purified drinking water. It was first used as a chemical weapon in World War I and most recently during insurgent attacks in the Iraq war. Domestic industrial facilities or rail cars en route are at greatest threat for intentional chlorine release involving an attack.

The Homeland Security Council estimates an attack on an industrial site in an urban area could lead to as many as 17,500 deaths and 100,000 hospitalizations from chlorine exposure.

"These statics prove the need for effective countermeasures that can be stockpiled, and our work addresses that need," Hoyle said.


'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Related biology news :

1. Medical College of Wisconsin researchers show molecule inhibits metastasis
2. Researchers study agings effect on the brain
3. Notre Dame researchers report progress on compound to treat neurological diseases
4. UNH researchers: Multibeam sonar can map undersea gas seeps
5. Chagas disease may be a threat in South Texas, says researcher
6. Researchers realize high-power, narrowband terahertz source at room temperature
7. Researchers: Apply public trust doctrine to rescue wildlife from politics
8. Dead Sea researchers discover freshwater springs and numerous micro-organisms
9. Eating balanced meals, farm-fresh produce benefits families, communities, nutrition researchers say
10. LSU researchers find impact of oil spill in marsh fish species
11. MU researchers find new insight into fatal spinal disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/1/2016)...  Today, the first day of American Heart Month, ... a first of its kind workplace health solution that ... the first application of Watson ... and Welltok will create a new offering that combines ... delivered on Welltok,s health optimization platform. The effort is ...
(Date:1/27/2016)... CHESTER, Ohio , Jan. 27, 2016  Rite ... supplier based in West Chester, Ohio ... their award winning service staff, based in ... technical capacity and ability to provide modifications, installations and ... John Dovalina , CEO of PLUS, commented, "PLUS has ...
(Date:1/22/2016)... 2016 http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ... the  "Global Behavioral Biometric Market 2016-2020" ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the ... Market 2016-2020"  report to their offering. ... http://www.researchandmarkets.com/research/4lmf2s/global_behavioral ) has announced the addition ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... The publishing industry has ... publishing is one of the popular publication models that has received wider acknowledgement ... and 3000+ International Conferences across the globe, OMICS International is all ...
(Date:2/9/2016)... 2016 This market research report on the ... prospects of the market in terms of revenue (USD ... in the manufacture of microbiology culture media and related ... market snapshot providing the overall information of various market ... section also provides the overall information and data analysis ...
(Date:2/9/2016)... BOSTON , Feb. 9, 2016 ... a data-driven, biological research approach, has announced the ... Financial Officer and Chief Operating Officer. Haddock brings ... corporate finance, including 12 years in senior financial ... global experience in business organizational management. ...
(Date:2/8/2016)... Feb. 8, 2016 Should antibiotic bone cement ... products to prevent infection after standard total hip or ... at ECRI Institute have been fielding a lot lately. ... Your Bottom Line?" --> "Antibiotic ... --> While there isn,t a ...
Breaking Biology Technology: