Navigation Links
UofL research holds promise of therapeutic approach for gum disease
Date:3/27/2012

University of Louisville researchers are a step closer to eliminating periodontal disease through their work to develop synthetic molecules that prevent a bacteria responsible for the disease from spreading throughout the mouth.

The discovery could lead to the formulation of a mouth rinse, toothpaste or tooth varnish to prevent the pathogen from establishing itself orally.

Donald Demuth, PhD, associate dean for research and enterprise, UofL School of Dentistry, received a patent today for his work to develop peptides that inhibit the interaction between P. gingivalis and Streptococcus gordonii and prevent P. gingivalis colonization of the mouth. Peptides are molecules formed when two or more amino acids join together; they are the building blocks of proteins in a cell.

"When P. gingivalis enters the oral environment, it seeks out interaction with the bacterium S. gordonii an otherwise benign organism in order to lay the ground work to propagate and ultimately gain a foothold below the gum line, leading to periodontal disease.

"UofL Oral Health and Systemic Disease Group director Richard Lamont characterized this bacterial interaction and based on those studies, my team developed a series of peptides that prevent P. gingivalis and S. gordonii from coming together," Demuth said.

Demuth found that administering the peptide in an animal model prevented P. gingivalis related bone loss the clinical symptom of periodontal disease -- and prevented the spread of the bacterium in the mouth.

"This is one of the first examples of a potential targeted therapeutic approach that may control periodontal disease," he said.

Demuth is building his research through collaboration with Frederick Luzzio, PhD, professor, UofL College of Arts & Sciences, Department of Chemistry. They hope to further develop organic molecule structures that mimic the active pepti
'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

0

GOOD

Page: 1 2

Related biology news :

1. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
2. Researchers unravel genetic mechanism of fatty liver disease in obese children
3. UC research: Saving habitat key to songbirds survival
4. Montreal researchers repel mortality in Malian mothers
5. UF researchers look for ways to make an emerging technology safe for environment
6. Brandeis scientists win prestigious prize for circadian rhythms research
7. UCSB researchers to examine the effects of year-old NOAA West Coast Catch Shares program
8. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
9. SDSCs big data expertise aiding genomics research
10. Young researcher taking fight against global killer to the next level in Vietnam
11. Space research institute honors Sen. Hutchison with Pioneer Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... at USC have found that a class of pharmaceuticals ... , The drugs, known as "TSPO ligands," are ... looked at the effects of TSPO ligand in young ... and in aged mice when pathology was quite severe," ... School of Gerontology. "TSPO ligand reduced measures of pathology ...
(Date:5/21/2013)... COLUMBIA, Mo. Cancers of all types become most ... body. Once cancer has reached this stage, it becomes ... numerous tumors that can develop. Now, researchers at the ... radioactive nanoparticles that target lymphoma tumor cells wherever they ... professor of oncology in the MU College of Veterinary ...
(Date:5/21/2013)... Widely available in pharmacies and health stores, phosphatidylserine ... oysters, and soy. Proven to improve cognition and ... older people experiencing memory impairment. Now a team ... Bochner of Tel Aviv University,s Department of ... same supplement improves the functioning of genes involved ...
Breaking Biology News(10 mins):Drugs found to both prevent and treat Alzheimer's disease in mice 2MU researchers develop radioactive nanoparticles that target cancer cells 2Common food supplement fights degenerative brain disorders 2
... Wash. An international team of scientists from Italy, France, ... sequence of the domestic apple genome in the current issue ... genome sequence for apple will allow scientists to more rapidly ... which genes and gene variants provide disease or drought resistance ...
... a chronic and often disabling condition. Despite modern ... to the patients and their relatives and take ... and societal expenditure. The diagnosis of ... structure and changes in neurotransmission, with increased dopamine ...
... (August 27, 2010) Although having a high body ... cardiovascular disease, researchers are only beginning to understand how ... of the disease. Now, a study of a subset ... (KEEPS), suggests that as BMI increases, so do platelet ...
Cached Biology News:Core knowledge of tree fruit expands with apple genome sequencing 2Core knowledge of tree fruit expands with apple genome sequencing 3Body mass index and thrombogenic factors in newly menopausal women 2Body mass index and thrombogenic factors in newly menopausal women 3
(Date:5/22/2013)... New York (PRWEB) May 22, 2013 ... the 3rd Annual Disruptive Innovations to Advance Clinical Trials ... Copley Plaza Hotel in Boston, MA. , Disruptive ... Janssen Pharmaceuticals and more share bold approaches to reduce ... , “Disruptive innovation needs to be big, or ...
(Date:5/22/2013)... Genedata, a leading provider of advanced ... life science research, today announced AB Enzymes will ... bioinformatics platform for strain genome data management on ... Enzymes, one of the world’s oldest and best-known ... Selector accompanied by bioinformatics consulting services. Genedata Selector, ...
(Date:5/22/2013)... Chicago, IL (PRWEB) May 22, 2013 Alton ... thetelegraph.com dated May 15, 2013 said that their presence ... help other bed bug sufferers avoid such big spending, My ... bugs inexpensively. , It was said in the report ... an exterminator, MCP related. Apart from that, its employees also ...
(Date:5/21/2013)... England , May 22, 2013 ... novel drug-only formulation of glycopyrronium bromide designed using Prosonix, ... pharmaceutical company developing a portfolio of inhaled Respiratory ... clinical study with PSX1002 that will assess its effect ... of doses in patients with moderate to severe chronic ...
Breaking Biology Technology:Disruptive Innovation Hits Clinical Trials, Dedicated Event Launches 2AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 2AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 3AB Enzymes Chooses Genedata Selector for Production Strain Development and Optimization 4Bed Bugs Cost Alton Housing Authority $35,000; New Help, How to Kill Bed Bugs With Less Expense, Introduced by My Cleaning Products 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 2Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 3Prosonix Initiates Phase 2 Clinical Study with PSX1002 in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) 4
... ... Clinical Applications, BOTHELL, Wash., Nov. ... developer and marketer of proprietary,hypothermic storage and cryopreservation media products ... a Master File to the,United States Food and Drug Administration ...
... Nov. 5 On Friday, November 7, 2008,at ... members,of Cell Therapeutics, Inc.,s (CTI) (Nasdaq: CTIC ... conference call to discuss the Company,s 2008,third quarter ... Numbers Friday, November 7 8:30 a.m. ...
... Inc.,(Nasdaq: TELK ) reported a net loss of ... ended September 30, 2008, compared with a net loss ... period in 2007. The,$8.0 million net loss includes a ... with an auction reset feature, or,auction rate securities, which ...
Cached Biology Technology:BioLife Solutions Submits FDA Master File on HypoThermosol(R) Preservation and Storage Media for Cells, Tissues 2BioLife Solutions Submits FDA Master File on HypoThermosol(R) Preservation and Storage Media for Cells, Tissues 3Telik Announces Financial Results for 2008 Third Quarter 2Telik Announces Financial Results for 2008 Third Quarter 3Telik Announces Financial Results for 2008 Third Quarter 4
... Ultra Agarose Spin Kit is an advanced system for ... purified DNA can be used directly for any downstream ... DNA is ready to use in 56 minutes ... used for TAE and TBE gels No specialised ...
... Kit has been designed for recovery of DNA from ... Features Ultra fast protocol: DNA is ready ... are easy to resuspend Bead uniformity prevents shearing ... (suitable for PCR) DNA is eluted into sterile ...
... DNA from agarose gels The SpinPrep Gel DNA ... bp to > 12,000 bp in size from agarose ... gel slice, followed by adsorption of the DNA to ... a wash step, the purified DNA is eluted in ...
BlotGel application pool -see Blotters (Semi-Dry) for more info...
Biology Products: