Navigation Links
UofL research holds promise of therapeutic approach for gum disease
Date:3/27/2012

University of Louisville researchers are a step closer to eliminating periodontal disease through their work to develop synthetic molecules that prevent a bacteria responsible for the disease from spreading throughout the mouth.

The discovery could lead to the formulation of a mouth rinse, toothpaste or tooth varnish to prevent the pathogen from establishing itself orally.

Donald Demuth, PhD, associate dean for research and enterprise, UofL School of Dentistry, received a patent today for his work to develop peptides that inhibit the interaction between P. gingivalis and Streptococcus gordonii and prevent P. gingivalis colonization of the mouth. Peptides are molecules formed when two or more amino acids join together; they are the building blocks of proteins in a cell.

"When P. gingivalis enters the oral environment, it seeks out interaction with the bacterium S. gordonii an otherwise benign organism in order to lay the ground work to propagate and ultimately gain a foothold below the gum line, leading to periodontal disease.

"UofL Oral Health and Systemic Disease Group director Richard Lamont characterized this bacterial interaction and based on those studies, my team developed a series of peptides that prevent P. gingivalis and S. gordonii from coming together," Demuth said.

Demuth found that administering the peptide in an animal model prevented P. gingivalis related bone loss the clinical symptom of periodontal disease -- and prevented the spread of the bacterium in the mouth.

"This is one of the first examples of a potential targeted therapeutic approach that may control periodontal disease," he said.

Demuth is building his research through collaboration with Frederick Luzzio, PhD, professor, UofL College of Arts & Sciences, Department of Chemistry. They hope to further develop organic molecule structures that mimic the active pepti
'/>"/>

Contact: Julie Heflin
julie.heflin@louisville.edu
502-852-7987
University of Louisville
Source:Eurekalert

Page: 1 2

Related biology news :

1. WHOI researchers, collaborators receive $1.4 million grant to study life in oceans greatest depths
2. Researchers unravel genetic mechanism of fatty liver disease in obese children
3. UC research: Saving habitat key to songbirds survival
4. Montreal researchers repel mortality in Malian mothers
5. UF researchers look for ways to make an emerging technology safe for environment
6. Brandeis scientists win prestigious prize for circadian rhythms research
7. UCSB researchers to examine the effects of year-old NOAA West Coast Catch Shares program
8. New paper by Notre Dame researchers describes method for cleaning up nuclear waste
9. SDSCs big data expertise aiding genomics research
10. Young researcher taking fight against global killer to the next level in Vietnam
11. Space research institute honors Sen. Hutchison with Pioneer Award
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... at the Department of Energy,s Oak Ridge National ... by R&D Magazine in recognition of the year,s ... the tremendous value of our National Labs," said ... at the National Labs continues to help our ... scientific and technological innovations necessary to remain globally ...
(Date:7/11/2014)... Bone and Mineral Research awarded Michael F. Holick, PhD, ... the 2014 Louis V. Avioli Award. Holick, a professor ... known for revolutionizing the understanding of vitamin D and ... honors a member of the American Society for Bone ... and mineral basic research. It is named for ASBMR,s ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
Breaking Biology News(10 mins):ORNL wins eight R&D 100s 2ORNL wins eight R&D 100s 3ORNL wins eight R&D 100s 4BUSM's Michael F. Holick receives American Society for Bone and Mineral Research award 2
... Research explains the American obesity paradox: the parallel rise in ... series of four studies, the researchers reveal that we over-generalize ... desserts containing up to 131% more calories when the main ... white view, most food is good or not good, explain ...
... priorities can drive local waste partnerships towards the achievement ... sustainable waste management objectives, a study funded by the ... of waste and disposing of it in environmentally acceptable ... other areas of public service delivery, partnership working is ...
... to tinker with a single amino acid of an ... according to molecular biologists who say the discovery could ... of making vaccines. "We have successfully tested this technique ... of biochemistry and molecular biology at Penn State. "And ...
Cached Biology News:You're likely to order more calories at a 'healthy' restaurant 2Central targets may hinder wider waste management objectives 2Central targets may hinder wider waste management objectives 3Discovery may help defang viruses 2Discovery may help defang viruses 3
(Date:7/10/2014)... Francisco, CA (PRWEB) July 10, 2014 ... family closer together. The Archer Family purchased a ... contained within DNA, but ended up with a lifetime ... discoveries contained within the family members’ DNA genuinely brought ... had decided to search deeper into genetic history and ...
(Date:7/10/2014)... POINT, Ind. , July 10, 2014 ... expanded its use of capnography for respiratory ... growing group of healthcare leaders in embracing ... measures how effectively patients are breathing and ... depression occurs. By measuring the amount of ...
(Date:7/10/2014)... --  Ceres, Inc . (Nasdaq: CERE ), ... results for the three months ended May 31, 2014 ... Ceres reported that the company and its customers have ... in Brazil, which concluded in June, despite dry and ... for part of the growing season. Yields of several ...
(Date:7/10/2014)... of psychiatric disorders has been extremely challenging because there ... are insufficient to cause disease. Now investigators reporting in ... Cell Stem Cell describe a strategy that ... with other risk factors or environmental exposures to affect ... a genetic variant that may predispose individuals to schizophrenia. ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... CV Therapeutics,Inc. (Nasdaq: CVTX ) announced today that ... (EMEA) for ranolazine for,the treatment of patients with chronic ... approval follows a positive opinion from the EMEA,Committee for ... 2008., Ranolazine is approved for use in Europe ...
... 10 Quest Diagnostics,Incorporated (NYSE: DGX ), the ... today that its second-quarter,2008 results will be made public ... it will hold its quarterly conference call with investors,to ... that day., The public may access the conference ...
... ALXN ), today announced that the Company will,conduct ... July 29, 2008, at,10:00 a.m. Eastern Time (ET), in ... second quarter ended June 30, 2008. Alexion,anticipates releasing its ... 2008., To participate in this conference call, dial ...
Cached Biology Technology:CV Therapeutics Receives European Marketing Authorization for Ranolazine for the Treatment of Patients With Chronic Angina 2CV Therapeutics Receives European Marketing Authorization for Ranolazine for the Treatment of Patients With Chronic Angina 3Quest Diagnostics to Release Second Quarter 2008 Financial Results 2
... exciting product for cell-based kinetic assays and ... use of expensive HTS equipment, which lead ... assay development stage. The NOVOstar offers the ... well as any other assay suitable for ...
... measures mitochondria intactness and detects events ... Features and Benefits: Fast, ... isolated mitochondria and for assaying mitochondria ... reagents required for the detection of ...
... save space and organize gloves, ... other garb. They are the ... small parts used in labs, ... Open-slot design for easy cleaning. ...
... handy dispensers save space and ... hats, and other garb. They ... bins for small parts used ... Clear acrylic. Many other sizes ...
Biology Products: