Navigation Links
Untangling whole genomes of individual species from a microbial mix
Date:5/23/2014

BETHESDA, MD May 23, 2014 A new approach to studying microbes in the wild will allow scientists to sequence the genomes of individual species from complex mixtures. It marks a big advance for understanding the enormous diversity of microbial communities including the human microbiome. The work is described in an article published May 22 in Early Online form in the journal G3: Genes|Genomes|Genetics, published by the Genetics Society of America.

"This new method will allow us to discover many currently unknown microbial species that can't be grown in the lab, while simultaneously assembling their genome sequences," says co-author Maitreya Dunham, a biologist at the University of Washington's Department of Genome Sciences.

Microbial communities, whether sampled from the ocean floor or a human mouth, are made up of many different species living together. Standard methods for sequencing these communities combine the information from all the different types of microbes in the sample. The result is a hodgepodge of genes that is challenging to analyze, and unknown species in the sample are difficult to discover.

"Our approach tells us which sequence fragments in a mixed sample came from the same genome, allowing us to construct whole genome sequences for individual species in the mix," says co-author Jay Shendure, also of the University of Washington's Department of Genome Sciences.

The key advance was to combine standard approaches with a method that maps out which fragments of sequence were once near each other inside a cell. The cells in the sample are first treated with a chemical that links together DNA strands that are in close proximity. Only strands that are inside the same cell will be close enough to link. The DNA is then chopped into bits, and the linked portions are isolated and sequenced.

"This elegant method enables the study of microbes in the environment," says Brenda Andrews, editor-in-chief
'/>"/>

Contact: Raeka Aiyar
press@genetics-gsa.org
202-412-1120
Genetics Society of America
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Untangling Alzheimers disease
2. Untangling lifes origins
3. Frozen meal eaters get more vegetables including greens, beans and whole grains but with lower total calories vs. fast food restaurant eaters
4. New method developed for ranking disease-causal mutations within whole genome sequences
5. Study suggests whole diet approach to lower CV risk has more evidence than low-fat diets
6. Whole-genome sequencing uncovers the mysteries of the endangered Chinese alligator
7. Whole genome sequencing of wild rice reveals the mechanisms underlying oryza genome evolution
8. Foods identified as whole grain not always healthy
9. Making whole wheat bread taste and smell more appetizing
10. New whole plant therapy shows promise as an effective and economical treatment for malaria
11. BGI Tech develops whole exome sequencing analysis of FFPE DNA samples to boost biomedicine
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Untangling whole genomes of individual species from a microbial mix
(Date:12/5/2014)... 2014 Increased emphasis on product quality, ... testing and inspection technologies. The convergence of industries ... range of innovative test solutions. This trend is ... which is generally more inclined towards communication, media ... strategies of test equipment vendors will cater to ...
(Date:11/21/2014)... 2014 According to a new ... (Video, RFID, Access Control, Intrusion Detection, Parking Management, Under ... Component Service Geography - Global Forecasts to 2020", published ... to be around $25 Billion in 2014 and is ... a CAGR of 8.69%. Browse 116 market ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Barbara, Calif.) By determining simple guidelines, researchers at ... (SSLEC) have made it possible to optimize phosphors ... for brighter, more efficient lights. "These guidelines should ... a rational rather than trial-and-error manner," said Ram Seshadri, ...
... stress, some people seem to lose their appetite while others ... wisdom tells us that stress eaters are the ones who ... that stress eaters show a dynamic pattern of eating behavior ... published in Psychological Science , a journal of the ...
... State Secretary for Education, Research and Innovation, Dr ... for the establishment of ELIXIR, the European Life ... the time when five Member States will have ... force. The Swiss government has committed to investing ...
Cached Biology News:Breakthrough research produces brighter, more efficiently produced lighting 2Breakthrough research produces brighter, more efficiently produced lighting 3Stress eaters may compensate by eating less when times are good 2Switzerland signs the ELIXIR consortium agreement and contributes €35 million 2
(Date:12/24/2014)... 23, 2014 Vermillion, Inc. (Nasdaq:   ... disease, announced today that investors including Oracle Investment ... LLC and several Vermillion directors have agreed to ... Vermillion,s common stock and warrants to purchase unregistered ... placement.  Under the terms of ...
(Date:12/22/2014)... Brussels (PRWEB) December 22, 2014 The ... the global leader of technical training across the life ... Clinical Data Management (SCDM) to provide the organization's ... certification programs —providing access to the more than 350 ... SCDM members with 10% off when registering for a ...
(Date:12/22/2014)... , Dec. 22, 2014  ( www.competitivehealth.com ) ... an online medical bill review and advocacy service, has ... the FREE WellCard Savings discount health services marketplace. ... that was more than they expected to pay. As ... health care costs, WellCard Savings is pleased to offer ...
(Date:12/19/2014)... Charm Sciences is pleased to announce ... of Aflatoxin M1 in raw commingled milk is the ... validation. The peer reviewed report of the validation by ... Agricultural and Fisheries Research (ILVO-T&V) has been published by ... the most toxic aflatoxin and a known carcinogen, can ...
Breaking Biology Technology:Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 2Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 3Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 4Vermillion Announces Equity Financing of up to $18.9 Million; Suspends ATM Program 5CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2
... Field Moving Toward Genotype-Guided Psychotropic TherapySAN FRANCISCO, May ... Genomas, and Director of Genetics Research at Hartford ... Psychiatry at the Mayo Clinic will co-chair a ... for Depressive Disorders ," at the annual meeting ...
... Austria, May 21 EUCODIS Bioscience, a company,developing, ... the,chemical industry, announced today that it has entered ... Danisco. Under the terms of the,agreement, EUCODIS Bioscience ... recombination" to the development of an optimized,version of ...
... Support the Global R&D and Healthcare CommunityPHILADELPHIA and LONDON, ... the global healthcare community working to prevent and address ... outbreak, the Healthcare and Science business of Thomson Reuters, ... and professionals, today announced the free availability of its ...
Cached Biology Technology:Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association 2EUCODIS Bioscience Signs Research Agreement With Genencor 2Thomson Reuters Makes Disease Briefing on Influenza Covering H1N1 (Swine Flu) Publicly Available 2Thomson Reuters Makes Disease Briefing on Influenza Covering H1N1 (Swine Flu) Publicly Available 3
... Tetrad thermal cycler expands the envelope ... DNA Engine cycler. It ... a footprint only twice the size, ... that run massive quantities of reactions, ...
... tube gel adaptors, 24 glass tubes (1.5 ... stoppers. The PROTEAN II xi cell and ... versatility to perform a variety of separations,* ... native, preparative, and gradient PAGE as well ...
... DNA Engine Tetrad 2 thermal cycler ... units (sample-holder, heat-pump assemblies), which hold ... A Pentium-class computer drives an advanced ... sample, and lid temperatures. Peltier heat ...
Printer paper for Model 680 series readers is used with the thermal printers of the Model 680 and Model 680 XR microplate readers. Supplied as 2 rolls....
Biology Products: