Navigation Links
Unravelling new complexity in the genome
Date:8/13/2007

o the power of a new tool that he, together with his colleagues including Profs. Brendan Frey (Department of Electrical and Computer Engineering) and Timothy Hughes (Banting and Best, CCBR), developed a few years ago. This tool, which comprises tailored designed microarrays or gene chips and computer algorithms, allows the simultaneous measurement of thousands of alternative splicing events in cells and tissues. Until recently researchers studied splicing regulation on a gene by gene basis. Now we can obtain a picture of what is happening on a global scale, which provides a fascinating new perspective on how genes are regulated, Blencowe explains.

A challenge now is to figure out how the alternative splicing process is regulated in a cell and tissue-specific manner. In their new paper in Genome Biology, Dr. Yoseph Barash, a postdoctoral fellow working jointly with Blencowe and Frey, has provided what is likely part of the answer. By applying computational methods to the gene chip data generated by Matthew Fagnani (an MSc student) and other members of the Blencowe lab, Barash has uncovered what appears to be part of a regulatory code that controls alternative splicing patterns in the brain.

One outcome of these new studies is that the alternative splicing process appears to provide a largely separate layer of gene regulation that works in parallel with other important steps in gene regulation. The number of genes and coordinated regulatory events involved in specifying cell and tissue type characteristics appear to be considerably more extensive than appreciated in previous studies, says Blencowe. These findings also have implications for understanding human diseases such as cancers, since we can anticipate a more extensive role for altered regulation of splicing events that similarly went unnoticed due to the lack of the appropriate technology allowing their detection.


'/>"/>
Contact: Benjamin Blencowe
b.blencowe@utoronto.ca
416-978-3016
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. NYU, Rockefeller researchers find complexity of regulation by microRNA genes
3. How E. coli bacterium generates simplicity from complexity
4. Evolution of irreducible complexity explained
5. Complexity constrains evolution of human brain genes
6. Man and mouse share genome structures
7. Affymetrix Unveils Plans to Double Plant and Animal Genome Microarray Offering
8. Whole genome fine map of rice completed
9. Genome-wide mouse study yields link to human leukemia
10. Study finds more than one-third of human genome regulated by RNA
11. A bacterial genome reveals new targets to combat infectious disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2015)... Canada , April 17, 2015 ... growing security concerns, and technological advancement to drive ... until 2020   According ... Saudi Arabia Biometric Systems Market Forecast &  Opportunities, 2020 ", biometric systems ... is projected to register growth at CAGR of ...
(Date:4/14/2015)... April 14, 2015  HYPR Corp. today announced ... ® ) Alliance tm , an industry consortium ... commit to share technology and collaborate to deliver ... interoperable, more secure and private, and easier to ... verification that protects sensitive user information and eliminates ...
(Date:4/14/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... growing mobile commerce market, announces that its Wocket® smart ... Design Awards under the category  ,Product Design – Technology,. ... are part of a global multi-disciplinary awards program. The ... marketplace, industry and judging panel. Winners will be announced ...
Breaking Biology News(10 mins):Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 2Saudi Arabia Biometric Systems Market to Grow at 22% Through 2020, Says TechSci Research 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
... Bio-NMR Center at the VIB Department of Molecular and Cellular ... a scientific breakthrough that made it into the leading science ... possible to determine the dynamic structure of proteins. So Flemish ... activity of certain proteins involved in the stress physiology of ...
... 9, 2010) Defeating the flu is challenging because the ... of its genetic code, making it difficult for scientists ... a timely manner. Now, a University of Miami (UM) ... from Stony Brook University have developed a rapid and ...
... most pivotal steps in evolution-the transition from unicellular to ... commonly believed, found a globe-spanning collaboration of scientists led ... and the US Department of Energy,s Joint Genome Institute. ... algae Volvox carteri and its closest unicellular ...
Cached Biology News:Flemish researchers provide the first experimental evidence of dynamic allostery in protein regulation 2Scientists use computer algorithms to develop seasonal flu vaccines 2Origins of multicellularity: All in the family 2Origins of multicellularity: All in the family 3
(Date:4/17/2015)... , April 17, 2015  Guggenheim Securities, the ... today announced the hiring of William Tanner ... Mr. Tanner will start work at Guggenheim ... York office. "Bill brings a ... research, to our experienced and highly acclaimed healthcare team," ...
(Date:4/16/2015)... April 17, 2015 Spirax Sarco, ... services, released their newly designed, state-of-the-art website in ... facing website effectively promotes the Spirax Sarco brand, ... the information that a site visitor might be ... company capabilities, industries serviced, the latest company news, ...
(Date:4/16/2015)... 2015 Proove Biosciences , Inc. ... BIO Contest for the 2015 BIO International Convention. ... BIO International Convention will take place June 15-18 at ... Buzz of BIO contest, industry leaders will be voting ... the conference. The community voting period began on April ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 The ... that the prestigious 2015 Borlaug CAST Communication Award ... member at Tuskegee University in Alabama. Award nominees ... material; public presentations; and/or the use of television, ... all three areas. As a specialist in the ...
Breaking Biology Technology:Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2Spirax Sarco website has a new look 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 2Proove Bisociences to Participate in the Buzz of BIO at the 2015 BIO International Convention 3The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2
... Overview , ... purification of a number of biological molecules. For example, antibodies may ... protein may be purified on the basis of its affinity for ... in a chromatographic column with a relatively large volume. This note ...
... Analysis of Gene Expression (SAGE) is a sequence-based approach to ... is a powerful tool, one of the more comprehensive methods ... leading to a profile of the expressed genes. 1 ... of genes expressed in a specimen. The ability to count ...
... , Introduction , ... is a genetic mapping technique that uses selective amplification of a subset of ... First developed for plant studies, AFLP analysis is used for a variety of ... genetic maps for new species. , ...
Cached Biology Technology:Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 2Use of ZipTip Pipette Tips for Microscale Affinity Mass Spectrometry 3Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 2Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 3Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 4Serial Analysis of Gene Expression Using ABI PRISM DNA Sequencers and BigDye Terminators 5Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems 2Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems 3Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems 4Amplified Fragment Length Polymorphism (AFLP) Analysis on Applied Biosystems Capillary Electrophoresis Systems 5
... These 2800mL PYREX Fernbach-style culture flasks ... of the flask bottom to achieve maximal ... have a large marking spot., A wide ... these bottles including:, Polypropylene colored caps ...
... is designed to allow kanamycin/neomycin selection in ... combines a prokaryotic promoter (gb2) for expression ... with a eukaryotic promoter (PGK) for expression ... The prokaryotic promoter gb2 is a slightly ...
... template is designed to allow neomycin/kanamycin selection ... FRT-PGK-gb2-neo-FRT template encodes the neomycin/kanamycin resistance gene ... expression of kanamycin resistance in E.coli ... expression of neomycin resistance in mammalian cells. ...
... This CLS number is a ... easily match Cornings product number. ... please order under the old ... customer service for assistance. ID ...
Biology Products: