Navigation Links
Unraveling biological networks
Date:3/5/2012

A new approach to disentangling the complexities of biological networks, such as the way in which proteins interact in our body's cells has been developed by researchers in China. The team's algorithm could allow biologists and biomedical researchers to unravel new clues about how cells work and what goes awry with such networks in various diseases, such as Alzheimer's disease and cancer.

We find networks everywhere in technology, in nature, in our bodies. They are ubiquitous in countless fields of research from electronic circuitry to social networks from transportation systems to biological systems. Researchers have demonstrated that although networks may superficially be very disparate in nature they nevertheless share many global properties, such as "small world" and "scale free" characteristics. This means that understanding one kind of network can help us understand another.

However, to dig deeper still into the universal characteristics of networks requires us to understand the basic structural elements present in a particular - the so-called network "motifs". Motifs are patterns of interconnections between the nodes in a network, whether transistors, neurons Facebook users, or in molecular biology, proteins. Motifs that occur in significantly larger numbers in real networks than in randomised networks can be used to characterise local features of even the most complex networks. With high-throughput analytical techniques, molecular biologists are beginning to uncover network motifs in protein systems, and likewise in metabolism, the brain, the spread of pathogens and many other areas of interest.

Computer scientists Guimin Qin and Lin Gao of Xidian University in Shaanxi, China, have devised an efficient algorithm for detecting motifs in protein networks. The algorithm first searches for specific non-tree-like sub-structures in a network that are not so commonly found in random networks. It then classifies these sub-structures and clusters them hierarchically to reveal the presence of recurring motifs in the network. The team has applied the algorithm to a network of protein-protein interaction (PPI) for the well-studied bacterium Escherichia coli and the yeast Saccharomyces cerevisiae.

"Our experimental results show that the algorithm can efficiently discover motifs, which are consistent with current biology knowledge," the team says. Importantly, however, the approach has also revealed several novel motifs previously unrecognised. "Our algorithm can detect several consensus motifs with a given size, which may help biologists go further into cellular process," the team adds.


'/>"/>

Contact: Lin Gao
lgao@mail.xidian.edu.cn
Inderscience Publishers
Source:Eurekalert

Related biology news :

1. Brain structure provides key to unraveling function of bizarre dinosaur crests
2. Physics, math provide clues to unraveling cancer
3. March of Dimes awards $250,000 prize to scientists unraveling the causes of muscular dystrophy
4. New book offers practical advice for unraveling the genetics of complex human diseases
5. Tel Aviv University President Co-authors Important Paper Unraveling the Effect of Spatial Organization on Intracellular Chemistry
6. Unraveling Alzheimers: Simple small molecules could untangle complex disease
7. Unraveling a new regulator of cystic fibrosis
8. Unraveling Batten disease
9. Biological sand filters, a practical approach to combat poverty and inequality
10. Argonne scientists peer into heart of compound that may detect chemical, biological weapons
11. GEN reports on novel tools for deciphering biological networks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... 2016 Paris Police Prefecture ... security solution to ensure the safety of people and operations ... the major tournament Teleste, an international technology group ... announced today that its video security solution will be utilised ... up public safety across the country. The system roll-out is ...
(Date:6/2/2016)...   The Weather Company , an IBM Business (NYSE: ... capability in which consumers will be able to interact with ... via voice or text and receive relevant information about the ... Marketers have long sought an advertising solution that can create ... relevant and valuable; and can scale across millions of interactions ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... BOSTON , June 27, 2016   Ginkgo ... biology to industrial engineering, was today awarded as ... a selection of the world,s most innovative companies. ... at scale for the real world in the ... organism engineers work directly with customers including Fortune ...
(Date:6/23/2016)... Seattle, WA (PRWEB) , ... June 23, 2016 ... ... technology, announces the release of its second eBook, “Clinical Trials Patient Recruitment and ... patient recruitment and retention in this eBook by providing practical tips, tools, and ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry Network ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission is ... projects are designed, built and brought to market. , The Design Lab is ...
Breaking Biology Technology: