Navigation Links
Unprecedented detail of intact neuronal receptor offers blueprint for drug developers
Date:8/26/2014

mbled."

For such a large complex, this was a challenging task. Using an exhaustive array of protein purification methods, Furukawa and Karakas were able to isolate the intact receptor. Their crystal structure reveals that the receptor looks much like a hot air balloon. "The 'basket' is what we call the transmembrane domain. It forms an ion channel that allows electrical signals to propagate through the neuron," explains Furukawa.

An ion channel is like a gate in the neuronal membrane. Ions, small electrically charged atoms, are unable to pass through the cell membrane. When the ion channel "gate" is closed, ions congregate outside the cell, creating an electrical potential across the cell membrane.

When the ion channel "gate" opens, ions flow in and out of the cell through the channel pores. This generates an electrical current that sums up to create pulses that rapidly propagate through the neuron. But the current can't jump from one neuron to the next. Rather, the electrical pulse triggers the release of chemical messengers, called neurotransmitters. These molecules traverse the distance between the neurons and bind to receptors, such as the NMDA receptor, on the surface of neighboring cells. There, they act much like a key, unlocking ion channels within the receptor and propelling the electrical signal across another neuron and, ultimately, across the brain.

The "balloon" portion of the receptor that Furukawa describes is found outside the cell. This is the region that binds to neurotransmitters. The structure of the assembled multi-subunit receptor complex, including the elusive ion channel, helps to explain some of the existing data about how NMDA receptors function. "We are able to see how one domain on the exterior side of the receptor directly regulates the ion channel within the membrane," says Furukawa. "Our structure shows why this particular domain, called the amino terminal domain, is important for the activity of the
'/>"/>

Contact: Tona Kunz
tkunz@anl.gov
630-252-5560
DOE/Argonne National Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research gives unprecedented 3-D view of important brain receptor
2. Technofossils -- an unprecedented legacy left behind by humans
3. Study of complete RNA collection of fruit fly uncovers unprecedented complexity
4. Arctic warmth unprecedented in 44,000 years, reveals ancient moss
5. New microscopes at NIH reveal live, developing cells in unprecedented 3-D clarity
6. An unprecedented threat to Perus cloud forests
7. Unprecedented control of genome editing in flies promises insight into human development, disease
8. Genome sequencing provides unprecedented insight into causes of pneumococcal disease
9. Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean
10. Oregon study details brain pathways linking visual function, running
11. Scientists launch far-ranging campaign to detail Front Range air pollution
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... the fish world, are the ideal animal in which ... moved from the ocean into tens of thousands of ... changing their skeleton to adapt to the new environment. ... sticklebacks now have turned up one of the genes ... change in that gene,s regulation in a freshwater population ...
(Date:9/18/2014)... has found clownfish larvae can swim up to 400 kilometres ... to cope with environmental change. , Clownfish spend their entire ... as babies they must wander the open ocean, says study ... for Coral Reef Studies (Coral CoE) at James Cook University. ... but now we,ve been given a rare glimpse into how ...
(Date:9/17/2014)... From accessible and affordable health care to reproductive ... depend on the ability of people to identify ... openly and respectfully, and find the most defensible ... practices to support these societal conversations?, The Hastings ... of Bioethical Issues have teamed up to publish ...
Breaking Biology News(10 mins):Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 2Counting fish teeth reveals regulatory DNA changes behind rapid evolution, adaptation 3Nemo's epic journey to find a new home 2Why bioethics literacy matters 2Why bioethics literacy matters 3
... change in the Southwest will likely eliminate Joshua trees from ... years, according to a new study led by U.S. Geological ... of future climate, an analysis of the climatic tolerances of ... to project the future distribution of Joshua trees. The study ...
... Washington, D.C.Recent climate modeling has shown that reducing ... would give the Earth a wetter climate in ... Ecology scientists Long Cao and Ken Caldeira offers ... when atmospheric carbon dioxide (CO2) concentrations are decreasing. ...
... European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have ... any protein of their choice with any of a ... by introducing a single reactive artificial amino acid. Published ... to label even rare proteins very precisely for optical ...
Cached Biology News:Uncertain future for Joshua trees projected with climate change 2Cutting carbon dioxide helps prevent drying 2
(Date:9/18/2014)... (PRWEB) September 18, 2014 A novel ... an MRI scanner is currently being tested as part ... Women's Hospital in Boston with the aim of determining ... can make prostate cancer biopsies faster, more accurate, less ... system also has the potential to deliver prostate cancer ...
(Date:9/18/2014)... , September 18, 2014 /PRNewswire/ ... Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) has announced ... Materials - Global Strategic Business Report" ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report analyzes the ... US$ Million by the following Product ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 On Tuesday, ... and Sen. Jim Risch for National Lab Day on ... from across the national laboratory system. Durbin and Risch ... aims to increase awareness of the reach of the ... and discoveries to address some of our nation's most ...
(Date:9/18/2014)... DUBLIN , Sept. 18, 2014 ... addition of the "Global N-acetylcysteine Industry Report ... The Global N-acetylcysteine Industry Report 2014 is ... state of the global N-acetylcysteine industry. ... industry including definitions, classifications, applications and industry chain ...
Breaking Biology Technology:Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global N-acetylcysteine Industry Report 2014 2
... For the second time in three years, the Best of ... Labs(R) as Utah,s top, company in the Medical ... /PRNewswire/ - American Biotech Labs, LLC (ABL), developer of a new ... today announced that the company has won the 2009 Utah Best ...
... ) today announced that management will present at the following two investor ... Global Healthcare Conference, Tuesday, June 9, 2009, ... Conference, Thursday, June 11, 2009, 11:00 ... and available for replay from Dendreon,s website, www.dendreon.com . ...
... Burbano to senior associate and project architects Tess Kavanagh and ... firm ( http://www.ratcliffarch.com ) provides a ... healthcare, academic and civic clients throughout the Western United States. ... 20 years of architectural design experience. He is currently ...
Cached Biology Technology:American Biotech Labs(R) Garners 2009 Utah Best of State Award 2American Biotech Labs(R) Garners 2009 Utah Best of State Award 3Ratcliff Promotes Jorge Burbano to Senior Associate; Tess Kavanagh and Tony Keung to Associate 2
Purified anti-mouse Tim-1...
Request Info...
Request Info...
Anti-ADP-Ribosylation Factor 1, clone 3F1 Immunogen: Synthetic peptide corresponding to the C-terminal amino acid sequence of human ARF1. Available Date: 38495...
Biology Products: