Navigation Links
Unprecedented control of genome editing in flies promises insight into human development, disease
Date:8/23/2013

MADISON In an era of widespread genetic sequencing, the ability to edit and alter an organism's DNA is a powerful way to explore the information within and how it guides biological function.

A paper from the University of WisconsinMadison in the August issue of the journal GENETICS takes genome editing to a new level in fruit flies, demonstrating a remarkable level of fine control and, importantly, the transmission of those engineered genetic changes across generations.

Both features are key for driving the utility and spread of an approach that promises to give researchers new insights into the basic workings of biological systems, including embryonic development, nervous system function, and the understanding of human disease.

"Genome engineering allows you to change gene function in a very targeted way, so you can probe function at a level of detail" that wasn't previously possible, says Melissa Harrison, an assistant professor of biomolecular chemistry in the UWMadison School of Medicine and Public Health and one of the three senior authors of the new study.

Disrupting individual genes has long been used as a way to study their roles in biological function and disease. The new approach, based on molecules that drive a type of bacterial immune response, provides a technical advance that allows scientists to readily engineer genetic sequences in very detailed ways, including adding or removing short bits of DNA in chosen locations, introducing specific mutations, adding trackable tags, or changing the sequences that regulate when or where a gene is active.

The approach used in the new study, called the CRISPR RNA/Cas9 system, has developed unusually fast. First reported just one year ago by scientists at the Howard Hughes Medical Institute and University of California, Berkeley, it has already been applied to most traditional biological model systems, including yeast, zebrafish, mice, the nematod
'/>"/>

Contact: Melissa Harrison
mharrison3@wisc.edu
608-262-2383
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Genome sequencing provides unprecedented insight into causes of pneumococcal disease
2. Study by Haverford College professor reveals unprecedented impact of Deepwater Horizon on deep ocean
3. Target 2 forms of iron to control cystic fibrosis lung infection
4. Journal of Control, Automation and Electrical Systems now published by Springer
5. Natural pest control protein effective against hookworm: A billion could benefit
6. Controlling genes with light
7. Gallo Center scientists identify key brain circuits that control compulsive drinking in rats
8. Circadian rhythms control bodys response to intestinal infections, UCI-led study finds
9. Single-cell transfection tool enables added control for biological studies
10. New formula invented for microscope viewing, substitutes for federally controlled drug
11. Global Biometrics and Border Control Award for DERMALOG
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... June 30, 2014  Aware, Inc. (NASDAQ: ... services, previously announced on June 26, 2014 that its ... of $1.75 per share, or approximately $40 million in ... 10, 2014 and a payment date of July 24, ... it had set an ex-dividend date for this special ...
(Date:7/10/2014)... COMMACK, N.Y. , July 2, 2014 ... Inc. (ABD) to announce the appointment of the world-renowned ... its Board of Directors. Dr. Ginsburg, with ... two facilities: NY Presbyterian Hospital and Good Samaritan Regional ... Breathing Pacemaker since the late 1980,s and is considered ...
(Date:7/10/2014)... , July 3, 2014 Research ... addition of the "Global Gesture Recognition & ... - Forecasts to 2020" report to their ... Global Gesture Recognition & Touch-Less Sensing Market ... around for a while, but the companies were ...
Breaking Biology News(10 mins):NASDAQ Sets Ex-Dividend Date for Aware, Inc.'s Special Cash Dividend of $1.75 Per Share 2Avery Biomedical Devices, Inc. announces the appointment of Mark E Ginsburg, M.D. to its Board of Directors 2Global Gesture Recognition & Touch-Less Sensing (2D, 3D, Ultrasonic, IR, Capacitive) Market - Forecasts to 2020 2
... mammoths and ancient American horses may have been grazing ... than previously thought. After plucking ancient DNA from frozen ... cutting-edge techniques to uncover "genetic fossils" of both species ... 10,500 calendar years. This new evidence suggests that at ...
... look forward to ultra-low powered or self powered electronic ... is made possible with power management and cutting-edge energy ... and higher energy efficiency in electronic devices and systems. ... for power management and energy harvesting. To pre-position the ...
... part of an international team that has used DNA samples ... of North America,s woolly mammoths and ancient horses. The ... Duane Froese and his colleagues counters an important extinction theory, ... concluded that more than half of the large mammals in ...
Cached Biology News:Late-surviving megafauna exposed by ancient DNA in frozen soil 2Late-surviving megafauna exposed by ancient DNA in frozen soil 3Late-surviving megafauna exposed by ancient DNA in frozen soil 4NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 2NTU and EDB launch S$50 million ($36 million) integrated circuit design research center 3
(Date:7/10/2014)... EvoDerma ’s NOOME Anti-Aging Motion has been upgraded for ... a second treatment cup to help prevent and smooth skin ... thinner on the edges for a softer contact with the ... surfaces on the face, neck and décolleté. Choose to use ... such as the cheeks and neck, or opt for the ...
(Date:7/10/2014)... 10, 2014  Kainos Capital, a firm specializing in ... that it has acquired the Slim-Fast brand from Unilever. ... Terms of the transaction were not disclosed. ... business that markets ready-to-drink shakes, powders, bars and snacks ... and in the United Kingdom ...
(Date:7/10/2014)... 2014 -- According to the International Atomic Energy ... comes from terrorists acquiring sufficient quantities of plutonium ... crude nuclear explosive device. The IAEA also notes ... involved gram-level quantities, which can be challenging to ... a new study appearing this week in the ...
(Date:7/10/2014)... extremely challenging because there are many genetic variants that ... Now investigators reporting in the July 3rd issue of ... describe a strategy that may help reveal how such ... environmental exposures to affect the development of the nervous ... predispose individuals to schizophrenia. , The work takes ...
Breaking Biology Technology:Introducing a New Bonus Treatment Cup for EvoDerma’s NOOME Anti-Aging Motion 2Kainos Capital Acquires Slim-Fast From Unilever 2Sensitive detection method may help impede illicit nuclear trafficking 2New strategy could uncover genes at the root of psychiatric illnesses 2
... HER3 Total Protein ... Assays in Collaborative Biomarker Study, SOUTH SAN FRANCISCO, ... ) today announced that scientific,collaborators have presented additional clinical ... means to measure HER2 total,protein and homodimer levels and ...
... Medline Industries, Inc., the,nation,s largest privately held manufacturer ... has signed a three-year agreement to,purchase mouth rinse ... personal care, infection control and diagnostic use in ... in the healthcare market, we are,happy to extend ...
... The 21st Century Health Care Forum discusses the future of Continuing ... ... FRANCISCO, June 2 Accredited online nursing courses,are replacing traditional classroom-based ... flexibility in,their credentialing options., Ann Johnson, CEO of Wild Iris ...
Cached Biology Technology:Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting 2Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting 3Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting 4Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting 5Monogram Announces Presentation of Clinical Data for the HERmark(TM) Breast Cancer Assay at the 44th ASCO Annual Meeting 6Medline Signs 3-Year Purchasing Agreement for Mouth Rinse From Chester Labs 2Modernizing Continuing Education With Online Courses 2
Amyloid stain....
...
Human sIL-2R/CD25 ELI-PAIR Kit...
STX18 Immunogen: STX18 (NP_058626, 101 a.a. ~ 200 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: