Navigation Links
Unlocking the therapeutic potential of SLC13 transporters
Date:6/18/2014

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

Members of the SLC13 transporter family play a key role in the regulation of fat storage, insulin resistance, and other processes. Some SLC13 transporters mediate the transport of Krebs cycle intermediatescompounds essential for the body's metabolic activityacross the cell membrane. Previous studies have shown that loss of one member of this family protects mice against obesity and insulin resistance, and loss of another results in reduced fat storage and extended lifespan in fruit flies. These findings hint at the therapeutic potential of targeting these transporters to combat metabolic disease, obesity, diabetes, and other conditions.

A recently obtained high-resolution structure of VcINDYa member of the SLC13 family found in the bacteria that causes cholerahas provided key structural insights, but understanding how these transporters function at the cellular level remains a mystery. To find out more, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) reconstituted VcINDY into small synthetic vesicles called liposomes that allowed them to monitor its activity in isolation. Led by Joseph Mindell, the team was thereby able to analyze the properties of VcINDY as a transporter and provide a model that lays the groundwork for future studies of SLC13 transporters, potentially providing the key that will enable researchers to unlock their therapeutic potential.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Unlocking the potential of bacterial gene clusters to discover new antibiotics
2. Unlocking a mystery of thalidomide
3. NREL unlocking secrets of new solar material
4. Western University study unlocking secrets of breast tissue
5. Field Museum to receive federal grant for unlocking 350 million years of biodiversity
6. NREL and Colombian oil firm unlocking agricultural waste feedstocks for biofuel
7. Unlocking fuel cell conductivity
8. Biologists unlocking the secrets of plant defenses, 1 piece at a time
9. Stem cells in neurodegeneration: challenges and future neurotherapeutic prospects
10. New theory of diabetic complications origin suggests need for new therapeutic approach
11. JAX researchers identify potential therapeutic target for wound-healing and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unlocking the therapeutic potential of SLC13 transporters
(Date:3/1/2017)... -- Aware, Inc. (NASDAQ: AWRE), a leading supplier of biometrics ... has resigned, effective March 3, 2017, as co-Chief ... Treasurer of Aware citing a desire to retire.  Mr. ... the Board of Directors of Aware. ... co-President, General Counsel has been named Chief Executive Officer, ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber ... announced it has led a $3.5 million investment in  ... platform. Strategic Cyber Ventures is DC based and is ... Hank Thomas . Ron Gula , also ... Ventures, also participated in this series A round of ...
(Date:2/21/2017)... and PORTLAND, Ore. , Feb. 22, ... Avamere Family of Companies (Avamere Health Services, Infinity Rehab, ... six-month research study that will apply the power of ... senior living and health centers. By analyzing data streaming ... gain insights into physical and environmental conditions, and obtain ...
Breaking Biology News(10 mins):
(Date:3/22/2017)... LEXINGTON, Mass. , March 22, 2017   ... collections, today announced that Doctors Pathology Service ... mid-Atlantic region of the United States ... the Delaware Health Information Network (DHIN) to ... researchers. The novel program, announced in ...
(Date:3/22/2017)... March 22, 2017   VWR ... of product and service solutions to laboratory ... has acquired EPL Archives, Inc., an international ... the entire regulated product research, development and ... storage and ancillary services. EPL Archives is ...
(Date:3/22/2017)... ... 21, 2017 , ... Aqua Design Innovations (ADI) has launched ... over $30,000 in the first 40 minutes of crowdfunding. EcoQube is a living ... and affordably, anywhere. , “Simply add fertilized water and in less than 10 ...
(Date:3/22/2017)... ... March 22, 2017 , ... March 22, 2017...Council for Agricultural Science and ... one that utilizes technological innovation in smart, sustainable ways. Humans depend on plants for ... aesthetics and environmental stability. This paper is the first in a series that connects ...
Breaking Biology Technology: