Navigation Links
Unlocking the therapeutic potential of SLC13 transporters
Date:6/18/2014

Researchers have provided the first functional analysis of a member of a family of transporter proteins implicated in diabetes, obesity, and lifespan. The study appears in the June issue of The Journal of General Physiology.

Members of the SLC13 transporter family play a key role in the regulation of fat storage, insulin resistance, and other processes. Some SLC13 transporters mediate the transport of Krebs cycle intermediatescompounds essential for the body's metabolic activityacross the cell membrane. Previous studies have shown that loss of one member of this family protects mice against obesity and insulin resistance, and loss of another results in reduced fat storage and extended lifespan in fruit flies. These findings hint at the therapeutic potential of targeting these transporters to combat metabolic disease, obesity, diabetes, and other conditions.

A recently obtained high-resolution structure of VcINDYa member of the SLC13 family found in the bacteria that causes cholerahas provided key structural insights, but understanding how these transporters function at the cellular level remains a mystery. To find out more, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) reconstituted VcINDY into small synthetic vesicles called liposomes that allowed them to monitor its activity in isolation. Led by Joseph Mindell, the team was thereby able to analyze the properties of VcINDY as a transporter and provide a model that lays the groundwork for future studies of SLC13 transporters, potentially providing the key that will enable researchers to unlock their therapeutic potential.


'/>"/>

Contact: Rita Sullivan King
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related biology news :

1. Unlocking the potential of bacterial gene clusters to discover new antibiotics
2. Unlocking a mystery of thalidomide
3. NREL unlocking secrets of new solar material
4. Western University study unlocking secrets of breast tissue
5. Field Museum to receive federal grant for unlocking 350 million years of biodiversity
6. NREL and Colombian oil firm unlocking agricultural waste feedstocks for biofuel
7. Unlocking fuel cell conductivity
8. Biologists unlocking the secrets of plant defenses, 1 piece at a time
9. Stem cells in neurodegeneration: challenges and future neurotherapeutic prospects
10. New theory of diabetic complications origin suggests need for new therapeutic approach
11. JAX researchers identify potential therapeutic target for wound-healing and cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Unlocking the therapeutic potential of SLC13 transporters
(Date:4/3/2017)... WASHINGTON , April 3, 2017 /PRNewswire-USNewswire/ ... single-cell precision engineering platform, detected a statistically ... cell product prior to treatment and objective ... highlight the potential to predict whether cancer ... prior to treatment, as well as to ...
(Date:3/29/2017)... , March 29, 2017  higi, the health ... in North America , today announced ... and the acquisition of EveryMove. The new investment and ... set of tools to transform population health activities through ... lifestyle data. higi collects and secures data ...
(Date:3/24/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Biometric Vehicle Access System ... over the next decade to reach approximately $1,580 million by 2025. ... forecasts for all the given segments on global as well as ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... ... is a basic first aid supply for any work environment, but most personal eye wash ... if a dangerous substance enters both eyes? It’s one less decision, and likely quicker response ... piece. , “Whether its dirt and debris, or an acid or alkali, getting anything in ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... ... , ... San Diego-based team building and cooking events company, Lajollacooks4u, has unveiled ... bold new look is part of a transformation to increase awareness, appeal to new ... , It will also expand its service offering from its signature gourmet cooking classes ...
(Date:10/10/2017)... 10, 2017 International research firm Parks Associates announced ... at the TMA 2017 Annual Meeting , October 11 in ... residential home security market and how smart safety and security products impact ... Parks Associates: Smart Home ... "The residential security market has ...
Breaking Biology Technology: