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Unlocking the secret(ase) of building neural circuits
Date:1/18/2011

archers had mapped to the gene coding for presenilin, stood out. Failing to exit the spinal cord, its motor neurons got stuck at the midline, a row of cells that lie, moat-like, in the middle of the developing embryo. Bai discovered that in presenilin mutant mice, they were irresistibly attracted to Netrin, which is expressed by the midline.

In normal mice, motor neurons turn a deaf ear to Netrin's siren call and head out to the periphery. They are able to ignore Netrin because the receptor for Netrin is blocked by the so-called Slit/Robo tag team. Without presenilin, however, Netrin receptor fragments that are resistant to Slit/Robo silencing accumulate in the cell, and the motor neurons are now attracted to Netrin.

"The most satisfying thing we have learned about presenilin is that this is a component that is not directly involved in the detection of signals either as a ligand or a receptor but functions as a very important regulator of their spatiotemporal activity," says Bai.


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Contact: Gina Kirchweger
Kirchweger@salk.edu
858-453-4100, x1340
Salk Institute
Source:Eurekalert  

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