Navigation Links
Unlocking mysteries of the brain with PET
Date:10/30/2009

Reston, Va.Inflammatory response of brain cellsas indicated by a molecular imaging techniquecould tell researchers more about why certain neurologic disorders, such as migraine headaches and psychosis in schizophrenic patients, occur and provide insight into how to best treat them, according to two studies published in the November issue of the Journal of Nuclear Medicine.

By using positron emission tomography (PET)a noninvasive molecular imaging techniqueresearchers were to able to identify neuroinflammation, which is marked by activated microglia cells (brain cells that are responsive to injury or infection of brain tissue) in patients with schizophrenia and in animal models with migraines. Although neuroinflammation has been shown to play a major role in many neurodegenerative disorderssuch as multiple sclerosis, Parkinson's disease and Alzheimer's diseaseonly limited data exists about the role of neuroinflammation in schizophrenia and migraines. The two studies in the Journal of Nuclear Medicine are the first to identify neuroinflammation in specific regions of the braina development which could be used to effectively evaluate the treatment response to anti-inflammatory drugs and become transformative for diagnosis and care.

"This study shows that molecular imaging can play an important role in better understanding the processes involving psychiatric and other neurological disorders," said Janine Doorduin, M.Sc., a researcher at the University Medical Center Groningen in the Netherlands and lead author of "Neuroinflammation in Schizophrenia-Related Psychosis: A PET Study." Doorduin added: "Without molecular imaging, the only way to look at inflammation in the brain, as well as other molecular processes, would be to use post-mortem brains."

Not much is known about the cause of schizophreniaa chronic and disabling brain disease characterized by psychotic episodes of delusions and hallucinations. Previously, evidence from post-mortem studies suggested the presence of activated microglia cells in the brain. However, the results of those studies were inconsistent. Using PET imaging to noninvasively image the living brains of schizophrenic patients, researchers in the Netherlands were able to pinpoint the neuroinflammation to an exact location in the brain, called the hippocampus. Now, researchers can target the hippocampus for further study and evaluate therapeutic treatments that could improve the quality of life for patients living with schizophrenia.

Likewise, PET imaging is also useful for identifying neuroinflammation associated with migraines. In the article, "11C-PK11195 PET for the In Vivo Evaluation of Neuroinflammation in the Rat Brain After Cortical Spreading Depression," researchers in Japan were the first to noninvasively visualize neuroinflammation in an animal model of migraine using a PET technique. Neuroinflammation is thought to be a key factor in the generation of pain sensation in migraine headaches. Observations from the study suggest that an inflammatory process may be involved in the pathologic state of migraines and that PET is a useful tool for evaluating the neurogenic inflammation in vivo.

"For physicians and patients, it is important to develop an objective method for the diagnosis of migraines and monitor therapeutic efficacy," said Yi-Long Cui, Ph.D., a researcher at the RIKEN Center for Molecular Imaging Science in Kobe, Japan, and lead author of the study. "The present study will bring about these possibilities to us since the PET probe used in the paper has already been applied to patients in other diseases."


'/>"/>

Contact: Amy Shaw
ashaw@snm.org
703-652-6773
Society of Nuclear Medicine
Source:Eurekalert

Related biology news :

1. Unlocking the function of enzymes
2. The key to unlocking the secret of highly specific DNAzyme catalysis
3. Unlocking mystery of why dopamine freezes Parkinsons patients
4. Unlocking the secret of the bladders bouncers
5. Team probes mysteries of oceanic bacteria
6. 1,000 tags reveal mysteries of giant bluefin tuna
7. Very cold ice films in laboratory reveal mysteries of universe
8. Ants may help researchers unlock mysteries of human aging process
9. Journal of General Physiology explores mysteries of TRP channels in latest Perspectives series
10. Why sleep? UCLA scientist delves into one of sciences great mysteries
11. Largest ever Alzheimers genome study unveils dementia mysteries
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2016)... --> ... report "Emotion Detection and Recognition Market by Technology (Bio-Sensors, NLP, ... Voice Recognition and Others), Services, Application Areas, End ... published by MarketsandMarkets, the global Emotion Detection and ... Billion by 2020, at a CAGR of 31.9%, ...
(Date:1/20/2016)... 2016  Synaptics Incorporated (NASDAQ: SYNA ), ... announced sampling of S1423, its newest ClearPad ® ... screen applications including smartwatches, fitness trackers, and touch ... rectangular shapes, as well as thick and curved ... on screen, while wearing gloves, and supports swipes ...
(Date:1/13/2016)... January 13, 2016 --> ... a new market report titled - Biometric Sensors Market - ... 2015 - 2023. According to the report, the global biometric sensors ... anticipated to reach US$1,625.8 mn by 2023, expanding at ... terms of volume, the biometric sensors market is expected ...
Breaking Biology News(10 mins):
(Date:2/9/2016)... ... February 09, 2016 , ... ... for Public Policy for the National Organization for Rare Disorders (NORD). Dorman will ... ensure their voices are heard throughout the drug regulatory review process. , “Adding ...
(Date:2/9/2016)... , Feb. 9, 2016 BERG, ... data-driven, biological research approach, has announced the appointment ... Officer and Chief Operating Officer. Haddock brings to ... finance, including 12 years in senior financial functions ... experience in business organizational management. ...
(Date:2/8/2016)... --> ... oncology company developing next generation cancer therapeutics that ... that chairman emeritus of Tata Sons Limited, Mr ... as part of the first close of Invictus,s ... Capital and Aarin Capital. http://photos.prnewswire.com/prnh/20150923/766442 ) ...
(Date:2/8/2016)... ... February 08, 2016 , ... Bulk food product inspection systems ... various stages of the production process. Despite frequently inspecting loose product prior to ... packaging such as sacks of dry powders. , Mettler-Toledo Product Inspection's brand-new white ...
Breaking Biology Technology: