Navigation Links
Unlike we thought for 100 years: Molds are able to reproduce sexually
Date:1/8/2013

For over 100 years, it was assumed that the penicillin-producing mould fungus Penicillium chrysogenum only reproduced asexually through spores. An international research team led by Prof. Dr. Ulrich Kck and Julia Bhm from the Chair of General and Molecular Botany at the Ruhr-Universitt has now shown for the first time that the fungus also has a sexual cycle, i.e. two "genders". Through sexual reproduction of P. chrysogenum, the researchers generated fungal strains with new biotechnologically relevant properties - such as high penicillin production without the contaminating chrysogenin. The team from Bochum, Gttingen, Nottingham (England), Kundl (Austria) and Sandoz GmbH reports in PNAS. The article will be published in this week's Online Early Edition and was selected as a cover story.

Only penicillin producer

About 100 years ago, Alexander Fleming demonstrated the formation of penicillin in Penicillium chrysogenum. To date, there is no other known producer of the antibiotic penicillin, which has an annual global market value of about six billion Euros.

Combining genes and breeding offspring with new properties

Not only animals and plants, but also many microorganisms such as fungi and algae can reproduce sexually. The advantage: the progenies possess a combination of genes from both mating partners and thus have new properties. Sexual reproduction in fungi is, however, not the rule. Most reproduce via spores which, in the case of moulds, occur as white, green or black deposits on spoiled food. These spores only bear the genes of one parent fungus. "Five years ago we already detected the existence of so-called sex genes in Penicillium chrysogenum", says Prof. Kck. Now, the researchers have discovered specific environmental conditions in which the fungus actually reproduces sexually. The decisive thing was to breed fungal strains in the dark under oxygen deprivation conditions in a nutrient medium supplemented with the vitamin biotin. The offspring exhibited new properties, both at the molecular level, as well as in their phenotypes.

Results could be applicable to other fungi

Using so-called microarray analysis, the biologists also investigated the activity of all the approximately 12,000 genes of the mould fungus. The result: the sex genes control the activity of biologically relevant genes, for example those for penicillin production. "We presume that the findings can also be applied to other fungi", says Ulrich Kck, "such as Penicillium citrinum and Aspergillus terreus that produce cholesterol-lowering statins, or Penicillium brevicompactum and Tolypocladium inflatum, which produce immunosuppressives that are used in all organ transplantations". The researchers conducted the work in the Christian Doppler Laboratory "Biotechnology of Fungi" at the Ruhr-Universitt with funding from the Christian Doppler Society (Vienna).


'/>"/>
Contact: Prof. Dr. Ulrich Kck
Ulrich.Kueck@rub.de
49-234-322-8212
Ruhr-University Bochum
Source:Eurekalert

Related biology news :

1. Climate warming unlikely to cause near-term extinction of Amazon trees, but threats remain
2. Warming climate unlikely to cause extinction of ancient Amazon trees, study finds
3. Report: Cleanup of some contaminated groundwater sites unlikely for decades
4. Research warns Asia unlikely to achieve climate, poverty goals unless womens rights are recognized
5. Nearly one-tenth of hemispheres mammals unlikely to outrun climate change
6. Most-used diabetes drug works in different way than previously thought
7. A better thought-controlled computer cursor
8. Empathy represses analytic thought, and vice versa
9. The fin whale, under more threat in the Mediterranean than thought
10. UConn researchers discover that red tide species is deadlier than first thought
11. Our coral reefs: In trouble - but tougher than we thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... 1, 2016 Favorable Government Initiatives ... and Criminal Identification to Boost Global Biometrics System Market ... TechSci Research report, " Global Biometrics Market By ... and Opportunities, 2011 - 2021", the global biometrics market ... on account of growing security concerns across various end ...
(Date:5/16/2016)... 2016   EyeLock LLC , a market leader ... of an IoT Center of Excellence in ... development of embedded iris biometric applications. EyeLock,s ... and security with unmatched biometric accuracy, making it the ... DNA. EyeLock,s platform uses video technology to deliver a ...
(Date:5/3/2016)... 2016  Neurotechnology, a provider of high-precision biometric ... Biometric Identification System (ABIS) , a complete system ... ABIS can process multiple complex biometric transactions with ... fingerprint, face or iris biometrics. It leverages the ... MegaMatcher Accelerator , which have been used ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- A person commits a crime, and the detective uses ... criminal down. An outbreak of foodborne illness makes ... uses DNA evidence to track down the bacteria that caused ... not. The FDA has increasingly used a complex, cutting-edge technology ... Put as simply as possible, whole genome sequencing is a ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)... Ky. , June 23, 2016 ... two Phase 1 clinical trials of its complement ... placebo-controlled, single and multiple ascending dose studies designed ... pharmacodynamics (PD) of subcutaneous injection in healthy adult ... subcutaneously (SC) either as a single dose (ranging ...
Breaking Biology Technology: