Navigation Links
University of the Basque Country study on proteins related to Alzheimer's
Date:10/16/2009

The cause, or at least one of the possible causes, of memory loss amongst Alzheimer sufferers is related to the location of certain proteins.

The aim of this University of the Basque Country (UPV/EHU) PhD thesis was to analyse the location of certain proteins related to Alzheimers. The author of the thesis was Ms Naroa Anabitarte Gonzalez and her work is entitled, Alzheimer gaixotasunarekin erlazionatutako proteinen ultraegitura mailako kokapena baldintza fisiologikoetan: APP eta PS1 arratoi helduen hipokanpoan (Ultrastructural location of the proteins related to Alzheimer's disease: APP and PS1 in the hyperfield of mature rats).

A number of studies were undertaken on the proteolysis of the APP protein and on the location of this process in the interior of the cell. It is not yet very clear where this proteolysis or rupture occurs. In this vein, with the help of an electronic microscope, Ms Anabitarte studied the location of the proteins related to Alzheimer's disease (APP and PS1) in the region of the plasma membrane

To this end, she employed a number of antibodies capable of recognising fragments of APP protein. She also used another antibody in order to analyse the location of the PS1 protein. According to the results, both are found in large concentrations in the membranes of the synapses. These results coincide with those from the other groups, given that they situate the APP and PS1 proteins in the synapses. Synapses are involved in the process of communication between neurones. Synaptic plasticity is the property arising from the nature and functioning of neurones when these make communication with each other. All memory and learning processes are based on the mentioned property. In order for synaptic plasticity to occur, a number of molecules have to participate, and the APP protein is one of the most important. To this end, it is important to know how and when the rupture or proteolysis of this protein occurs.

Depending on the enzymes taking part in the proteolysis of the APP protein, different fragments are formed. One of the most important enzymes taking part in this process is Presenilin-1 (PS1). The fragments formed have different functions and some of these may have deleterious consequences. Thus, according to the author of the thesis, it is of utmost importance to know how proteolysis occurs, given that this is directly related to Alzheimer's disease.


'/>"/>

Contact: Irati Kortabitarte
iratik@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. ICU patients on ventilators flex and stretch in study at Case Western Reserve University
2. Concordia University to build innovative Environmental Chamber
3. Concordia University to build innovative centre for health research and training
4. Concordia University to construct new building for genomics research
5. Science wins fight over evolution in schools, says Case Western Reserve University author
6. Heartburn drugs deemed safe for fetuses according to Ben-Gurion University researchers
7. NIH funds new phase of high school-university research partnership
8. University of Washington receives $25 million to create Northwest Genomics Center
9. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
10. NTU, University of Warwick to collaborate in neuroscience research
11. Nanyang Technological University and UK partners heightens cooperation in water industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/26/2016)... BANGALORE, India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a ... ), and Onegini today announced a partnership to ... banking solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... banks to provide their customers enhanced security to ...
(Date:4/15/2016)... CHICAGO , April 15, 2016  A ... companies make more accurate underwriting decisions in a ... offering timely, competitively priced and high-value life insurance ... health screenings. With Force Diagnostics, rapid ... and lifestyle data readings (blood pressure, weight, pulse, ...
(Date:4/13/2016)...  IMPOWER physicians supporting Medicaid patients in ... standard in telehealth thanks to a new partnership with ... IMPOWER patients can routinely track key health measurements, such ... and, when they opt in, share them with IMPOWER ... local retail location at no cost. By leveraging this ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Raleigh, NC (PRWEB) , ... June 24, 2016 , ... ... find the most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings ... here to read it now. , Diagnostic biomarkers are signposts in the blood, ...
(Date:6/23/2016)... /PRNewswire/ - FACIT has announced the creation of ... company, Propellon Therapeutics Inc. ("Propellon" or "the Company"), ... portfolio of first-in-class WDR5 inhibitors for the treatment ... represent an exciting class of therapies, possessing the ... cancer patients. Substantial advances have been achieved with ...
(Date:6/23/2016)...  The Prostate Cancer Foundation (PCF) is pleased to announce 24 ... for prostate cancer. Members of the Class of 2016 were selected from a ... Read More About the Class of 2016 PCF Young Investigators ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample ... the Arkansas State Crime Laboratory, has joined STACS DNA as a Field Application Specialist. ... said Jocelyn Tremblay, President and COO of STACS DNA. “In further expanding our capacity ...
Breaking Biology Technology: