Navigation Links
University of the Basque Country study on proteins related to Alzheimer's
Date:10/16/2009

The cause, or at least one of the possible causes, of memory loss amongst Alzheimer sufferers is related to the location of certain proteins.

The aim of this University of the Basque Country (UPV/EHU) PhD thesis was to analyse the location of certain proteins related to Alzheimers. The author of the thesis was Ms Naroa Anabitarte Gonzalez and her work is entitled, Alzheimer gaixotasunarekin erlazionatutako proteinen ultraegitura mailako kokapena baldintza fisiologikoetan: APP eta PS1 arratoi helduen hipokanpoan (Ultrastructural location of the proteins related to Alzheimer's disease: APP and PS1 in the hyperfield of mature rats).

A number of studies were undertaken on the proteolysis of the APP protein and on the location of this process in the interior of the cell. It is not yet very clear where this proteolysis or rupture occurs. In this vein, with the help of an electronic microscope, Ms Anabitarte studied the location of the proteins related to Alzheimer's disease (APP and PS1) in the region of the plasma membrane

To this end, she employed a number of antibodies capable of recognising fragments of APP protein. She also used another antibody in order to analyse the location of the PS1 protein. According to the results, both are found in large concentrations in the membranes of the synapses. These results coincide with those from the other groups, given that they situate the APP and PS1 proteins in the synapses. Synapses are involved in the process of communication between neurones. Synaptic plasticity is the property arising from the nature and functioning of neurones when these make communication with each other. All memory and learning processes are based on the mentioned property. In order for synaptic plasticity to occur, a number of molecules have to participate, and the APP protein is one of the most important. To this end, it is important to know how and when the rupture or proteolysis of this protein occurs.

Depending on the enzymes taking part in the proteolysis of the APP protein, different fragments are formed. One of the most important enzymes taking part in this process is Presenilin-1 (PS1). The fragments formed have different functions and some of these may have deleterious consequences. Thus, according to the author of the thesis, it is of utmost importance to know how proteolysis occurs, given that this is directly related to Alzheimer's disease.


'/>"/>

Contact: Irati Kortabitarte
iratik@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. ICU patients on ventilators flex and stretch in study at Case Western Reserve University
2. Concordia University to build innovative Environmental Chamber
3. Concordia University to build innovative centre for health research and training
4. Concordia University to construct new building for genomics research
5. Science wins fight over evolution in schools, says Case Western Reserve University author
6. Heartburn drugs deemed safe for fetuses according to Ben-Gurion University researchers
7. NIH funds new phase of high school-university research partnership
8. University of Washington receives $25 million to create Northwest Genomics Center
9. Case Western Reserve University discovers Merkel cell originates from skin, not the neural crest
10. NTU, University of Warwick to collaborate in neuroscience research
11. Nanyang Technological University and UK partners heightens cooperation in water industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2017)... 2, 2017 Who risk to be deprived ... the full report: https://www.reportbuyer.com/product/4313699/ WILL APPLE ... FIELD? Fingerprint sensors using capacitive technology represent a ... vendor Idex forecasts an increase of 360% of the ... of the fingerprint sensor market between 2014 and 2017 ...
(Date:2/28/2017)... LOS ANGELES , Feb. 28, 2017   ... identity verification software globally, announces significant enhancements to new ... in May 2016. New products include mobile and desktop ... and DocX TM - a real time manual ... Acuant,s core idScanĀ® technology provides the fastest and most ...
(Date:2/27/2017)... , Feb. 27, 2017   Strategic Cyber Ventures ... it has led a $3.5 million investment in  Polarity ... Strategic Cyber Ventures is DC based and is led ... Hank Thomas . Ron Gula , also a ... also participated in this series A round of funding. ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... Mass spectrometry ... The utilization of this technology is driven by its potential to perform challenging analyses ... are also some challenges that must be addressed for it to be routinely used ...
(Date:3/28/2017)... 28, 2017 Summary This report ... Biochem and its partnering interests and activities since 2010. ... an in-depth insight into the partnering activity of one of ... company reports are prepared upon purchase to ensure inclusion of ... The report will be delivered in PDF format within ...
(Date:3/28/2017)... , March 28, 2017 Dr. ... life sciences corporation Anpac Bio-Medical Science Company ... new, international record, processing and reporting over 40,000 ... Differentiation Analysis" (CDA) liquid biopsy tests. ... Prize Laureate Summit publications, Anpac Bio,s CDA medical ...
(Date:3/28/2017)... ... March 28, 2017 , ... ... its brand-new, fully-certified hygienic SWB805 MultiMountTM weigh modules. These weigh modules are ... certified by National Sanitation Foundation (NSF). , As fully integrated weighing solutions, ...
Breaking Biology Technology: