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University of Wisconsin chemists find new compounds to curb staph infection
Date:5/23/2013

erium uses to regulate quorum sensing. The new agents devised by Blackwell and her group work on the four subtypes of staph, all of which use different quorum sensing signals and are found in different infection types.

"We had not worked much in this area because the (signaling molecules) are somewhat challenging to synthesize," explains Blackwell. "We now have developed methods to make these molecules and analogs much more efficiently, which helped fuel this new study."

For now, the compounds devised by the Wisconsin team will have their greatest impact in the lab as research probes to further study the role of quorum sensing in Staphylococcus aureus. In addition, the gritty details of how these synthetic agents work in the cell need to be determined in order to optimize their potential use in both the lab and clinic. Such studies are ongoing.

"The impact of these new peptides could be significant because staph is an important and increasingly scary pathogen. There is plenty of scope," notes Blackwell.


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Contact: Helen Blackwell
blackwell@chem.wisc.edu
608-262-1503
University of Wisconsin-Madison
Source:Eurekalert

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