Navigation Links
University of Wisconsin chemists find new compounds to curb staph infection
Date:5/23/2013

MADISON, Wis. In an age when microbial pathogens are growing increasingly resistant to the conventional antibiotics used to tamp down infection, a team of Wisconsin scientists has synthesized a potent new class of compounds capable of curbing the bacteria that cause staph infections.

Writing online in the Journal of the American Chemical Society, a group led by University of Wisconsin-Madison chemistry Professor Helen Blackwell describes agents that effectively interfere with the "quorum sensing" behavior of Staphylococcus aureus, a bacterium at the root of a host of human infections ranging from acne to life-threatening conditions such as pneumonia, toxic shock syndrome and sepsis.

"It's a whole new world for us," says Blackwell, whose group identified peptide-based signaling molecules that effectively outcompete the native molecules the bacterium uses to communicate and activate the genes that cause disease.

Bacteria use quorum sensing to assess their population density and coordinate certain behaviors. They do so through the use of pheromone-like chemicals, which bind to receptors either in the bacterial cell or on its surface and tell it if there are enough companion bacteria around to switch on genes that perform certain functions. In the case of Staphylococcus aureus, quorum sensing activates toxin production, manifesting disease in the host.

Interfering with bacterial quorum sensing to stymie disease is considered a promising new antibiotic strategy, says Blackwell. Staph, she adds, is an excellent target as the bacterium is not only a prevalent pathogen, but some strains, notably methicillin-resistant Staphylococcus aureus or MRSA, have developed resistance to commonly used antibiotics such as penicillin and its derivatives.

The new compounds synthesized by Blackwell and her colleagues are peptides that work at very low concentrations by blocking the chemical receptors the bact
'/>"/>

Contact: Helen Blackwell
blackwell@chem.wisc.edu
608-262-1503
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Maryland Medical Center launches genetic-testing program for cardiac patients
2. University of Maryland School of Medicine researchers find potential novel treatment for influenza
3. University of Houston engineering professor awarded grant to study melanoma treatment
4. Saint Louis University, University of Toronto biologists help decode turtle genome
5. Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
6. Indiana University associate professor earns APSs Henry Pickering Bowditch Award
7. University of Southern California scientists reveal natural process that blocks viruses
8. University of Houston engineering researchers theories to be tested in space
9. University of Tennessee professors research shows Gulf of Mexico resilient after spill
10. Mercyhurst Universitys new DNA sequencer to accelerate scientific research in region
11. Student named universitys first Lawrence scholar, researching at national laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
(Date:11/5/2014)... Janeiro, Brazil -Individuals show great diversity in their ability ... and females greatly differ in their perceptual evaluation of ... smell tests. , Sex differences in olfactory ... and may be connected to one,s perception of smell, ... Thus, women,s olfactory superiority has been suggested to be ...
(Date:11/4/2014)... published research study examining only marketing directed at ... food restaurants has found that the majority of ... to such marketing tactics. , Authored by Arizona ... the study is the first to examine the ... exterior of fast food restaurants and its relationship ...
Breaking Biology News(10 mins):Migration negation 2Migration negation 3The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3
... disappearing. These fearsome yet charismatic fish continue to fall ... of extinction as a result. New research shows that ... work shows that the deeper sharks live, the longer ... are just now learning critical details of their behavior, ...
... evolution of human speech was far more complex than is ... specific gene, says Robert Berwick, professor of computational linguistics at ... a session at the annual meeting of the American Association ... session is called Mind of a Toolmaker, and explores the ...
... French . , Sharks are disappearing from the worlds ... by more than half due to increased demand for shark ... and swordfish fisheries, where millions of sharks are taken as ... sharks has been assessed by the World Conservation Union (IUCN), ...
Cached Biology News:New research reveals shark superhighways and hotspots 2New research reveals shark superhighways and hotspots 3New research reveals shark superhighways and hotspots 4MIT: No easy answers in evolution of human language 2MIT: No easy answers in evolution of human language 3Ocean's fiercest predators now vulnerable to extinction 2
(Date:11/26/2014)... Boston, MA (PRWEB) November 26, 2014 ... and collaboration company is proud to announce that Darren ... Development and Sales. Darren will drive the ... and positive customer experience. , Darren brings ... He has held key roles in channel operations, from ...
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... Acid Industry is an in-depth research report on ... analysis, the report introduces Palmitic Acid, basic information, ... overview, policy analysis, and news analysis, etc. ... report analyzes Palmitic Acid market in ...
(Date:11/26/2014)... 25, 2014 Bio-Techne Corporation (NASDAQ: ... Robert Gavin to serve in a newly created ... Division.  Mr. Gavin will be responsible for managing the ... the ProteinSimple business acquired in July 2014 and the ... Jose, California -based ProteinSimple develops and commercializes proprietary ...
(Date:11/26/2014)... WARREN, N.J. , Nov. 25, 2014  Roka Bioscience, ... focused on providing advanced testing solutions for the detection of ... will present at the Piper Jaffray  26 th Annual ... conference will be held at The New York Palace in ... During this presentation, material information concerning the Company, its operations, ...
Breaking Biology Technology:SoundConnect Appoints Director of Channel Development & Sales 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 2Palmitic Acid Industry Global 2014 Analysis & 2020 Forecasts on Market data, Statics, Development Now at ReportsnReports.com 3Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3Roka Bioscience to Present at the Piper Jaffray Healthcare Conference 2
... and Former Senior Executive at ImClone Brings Substantial,Oncology ... 29 Senesco,Technologies, Inc. ("Senesco" or the "Company") ... Harlan W. Waksal, M.D., 55 to its board,of ... nine members,seven of whom are independent., (Photo: ...
... Appoints Euan MacIntyre, Ph.D. as Senior Vice ... Oct. 29 Arete Therapeutics Inc., a,privately-held ... inhibitors, today named D. Euan MacIntyre, Ph.D.,to ... Drug Discovery. Dr.,MacIntyre brings over 20 years ...
... Corporation,(Nasdaq: DRRX ) announced today that ... Alpharma Ireland Limited, an affiliate of,Alpharma Inc. ... the exclusive worldwide,rights to develop and commercialize ... review under the,Hart-Scott-Rodino (HSR) Antitrust Improvements Act ...
Cached Biology Technology:Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 2Senesco Appoints Harlan W. Waksal, M.D., to Board of Directors 3Arete Therapeutics Bolsters Management Team 2DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 2DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 3DURECT's Collaboration With Alpharma Clears HSR Review and Is Effective 4
... The DIGIVIEW line of digital x-ray ... radiation imaging device complete with 12 to ... area consists of a photodiode array sensor ... All models are available in low x-ray ...
... Chemicon Select Tissue Arrays are intended for ... tissues were fixed in neutral buffered formalin ... and diagnosis was performed by certified pathologists. ... paraffin blocks and relocated into a new ...
Metamine is an autonomous data mining tool that extends the capabilities of conventional research teams. It is a proactive agent that searches for significant results buried within the GeNet data rep...
... The desk-top XCAT 50 X-Ray System from KUBTEC ... to provide two and three dimensional representation of ... provides volumetric reconstruction of specimen X-ray images, the ... provide high level of detail in standard 2D ...
Biology Products: