Navigation Links
University of Wisconsin chemists find new compounds to curb staph infection
Date:5/23/2013

MADISON, Wis. In an age when microbial pathogens are growing increasingly resistant to the conventional antibiotics used to tamp down infection, a team of Wisconsin scientists has synthesized a potent new class of compounds capable of curbing the bacteria that cause staph infections.

Writing online in the Journal of the American Chemical Society, a group led by University of Wisconsin-Madison chemistry Professor Helen Blackwell describes agents that effectively interfere with the "quorum sensing" behavior of Staphylococcus aureus, a bacterium at the root of a host of human infections ranging from acne to life-threatening conditions such as pneumonia, toxic shock syndrome and sepsis.

"It's a whole new world for us," says Blackwell, whose group identified peptide-based signaling molecules that effectively outcompete the native molecules the bacterium uses to communicate and activate the genes that cause disease.

Bacteria use quorum sensing to assess their population density and coordinate certain behaviors. They do so through the use of pheromone-like chemicals, which bind to receptors either in the bacterial cell or on its surface and tell it if there are enough companion bacteria around to switch on genes that perform certain functions. In the case of Staphylococcus aureus, quorum sensing activates toxin production, manifesting disease in the host.

Interfering with bacterial quorum sensing to stymie disease is considered a promising new antibiotic strategy, says Blackwell. Staph, she adds, is an excellent target as the bacterium is not only a prevalent pathogen, but some strains, notably methicillin-resistant Staphylococcus aureus or MRSA, have developed resistance to commonly used antibiotics such as penicillin and its derivatives.

The new compounds synthesized by Blackwell and her colleagues are peptides that work at very low concentrations by blocking the chemical receptors the bact
'/>"/>

Contact: Helen Blackwell
blackwell@chem.wisc.edu
608-262-1503
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Maryland Medical Center launches genetic-testing program for cardiac patients
2. University of Maryland School of Medicine researchers find potential novel treatment for influenza
3. University of Houston engineering professor awarded grant to study melanoma treatment
4. Saint Louis University, University of Toronto biologists help decode turtle genome
5. Wayne State University startup, Advaita, to participate in new Michigan I-Corps program
6. Indiana University associate professor earns APSs Henry Pickering Bowditch Award
7. University of Southern California scientists reveal natural process that blocks viruses
8. University of Houston engineering researchers theories to be tested in space
9. University of Tennessee professors research shows Gulf of Mexico resilient after spill
10. Mercyhurst Universitys new DNA sequencer to accelerate scientific research in region
11. Student named universitys first Lawrence scholar, researching at national laboratory
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/27/2015)... , April 27, 2015  For more than ... trade show has been the premier worldwide event for ... 2015 is a must-attend event for any local, national, ... into the emerging commercial markets and current applications of ... innovations of this projected $48 billion industry, and how ...
(Date:4/27/2015)... FORT LAUDERDALE, Fla. , Apr. 27, 2015 /PRNewswire/ ... provider of access control and security systems is pleased ... joined the company as a consultant and member of ... Bedore is widely known as a thought leader ... Socrates Distance Learning Technology Group, and has published studies ...
(Date:4/20/2015)... April 20, 2015 Huntington Memorial Hospital is ... implant a new miniaturized, wireless monitoring sensor to manage ... first and only FDA-approved heart failure monitoring device that ... used by physicians to manage heart failure. ... implanted in the pulmonary artery (PA) during a non-surgical ...
Breaking Biology News(10 mins):UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 2Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 3Profile Solutions Names Medicinal Cannabis, Agriculture and Technology Expert Dr. Gerry Bedore to its Scientific Advisory Board 4Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... has again vetoed the Stem Cell Research Enhancement ... stem cell research. AAAS, the world’s largest general ... Americans spanning all parties and faiths that supports ... embryonic stem cell research is an extremely promising ...
... words — talking with a therapist or friend, writing in ... brain imaging study by UCLA psychologists reveals why verbalizing our ... , Another study, with the same participants and three of ... with ancient Buddhist teachings to provide the first neural evidence ...
... Researchers studying the genetics behind why C. difficile causes disease ... do it because they are starving. That just might help ... a very difficult disease to treat. , "The genes responsible ... of nutrient deprivation. This is consistent with the ...
Cached Biology News:AAAS decries latest stem cell veto 2AAAS decries latest stem cell veto 3Putting feelings into words produces therapeutic effects in the brain 2Putting feelings into words produces therapeutic effects in the brain 3Putting feelings into words produces therapeutic effects in the brain 4Putting feelings into words produces therapeutic effects in the brain 5Understanding why C. difficile causes disease -- it's hungry 2
(Date:5/5/2015)... May 5, 2015 ImmunoCellular Therapeutics, Ltd. ... Gengos , President and Chief Executive Officer, will ... DATE:  Thursday, May 7, 2015     TIME:  11:30 ... > click the red "register/ watch presentations" ... interactive online event where investors are invited to ...
(Date:5/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4r95kr/clinical ) ... Laboratory, Molecular Diagnostics and Genomic Testing Services Market ... Version" report to their offering. ... molecular diagnostics and pharmacogenics hold the promise of ... is moving out of the national and regional ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 GEA ... last week as recipients of the INTERPHEX Exhibitor ... recognition of their Portable, Continuous, Miniature and Modular ... a small footprint, continuous processing equipment, smart control ... process API powders and inactive ingredients into bulk ...
(Date:5/4/2015)... FRANCISCO, Calif. , May 4, 2015 /PRNewswire/ ... biopharmaceutical company focused on the development and commercialization ... announced today the completion of its merger with ... In conjunction with the closing of the merger, ... a combination of new investors and all current ...
Breaking Biology Technology:ImmunoCellular Therapeutics to Webcast Live at VirtualInvestorConferences.com on May 7 2European Clinical Laboratory, Molecular Diagnostics and Genomic Testing Services Market 2015-2019 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 2GEA Pharma Systems, G-CON Manufacturing and Pfizer Consortium Receives Best Technology Innovation Award at INTERPHEX 2015 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 2Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 3Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 4Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 5Tobira Therapeutics Completes Financing and Merger with Regado Biosciences 6
... old Web site is history. The society recently redesigned their ... Wisconsin, the latter of which exhibits quirky Wisconsin facts -- ... their whiskey during Prohibition (hint: it involves a cat). ... use this technology. , ,The XML-based RSS feeds allow specific ...
... H&Q conference in San Francisco is still seeping out (even though ... Journal), the overall sentiment from the meeting seems to be one ... IPOs queued up now. The outcome of the Eyetech IPO (expected ... of this IPO will be closely monitored. The last time the ...
... - The first-prize winner in the Governor's Business Plan ... according to a recent announcement by Secretary Cory ... $105,000 the amount already raised for prizes in the ... until Jan. 31. Gov. Doyle unveiled the contest at ...
Cached Biology Technology:Wisconsin Historical Society Embraces New Web Site Technology 22003 Biotech Results 2Business Plan Bounty Increases to $105,000 2
... Vector is specifically designed to target and ... Saccharomyces cerevisiae. Displayed proteins can be analyzed ... or putative ligands. pYD1 uses the a-agglutinin ... domains Aga1 and Aga2 to display recombinant ...
... Aph-1a (Aph-1aL,S Loop 92-115), O2F1 Affinity ... a multiprotein complex consisting of presenilin, ... proteins are necessary for full proteolytic ... cleavage of a number of integral ...
TGase3 (S-20)...
Mouse monoclonal [HYB 232-02] to Protein S ( Abpromise for all tested applications). entrezGeneID: 5627 SwissProtID: P07225...
Biology Products: