Navigation Links
University of Toronto finds humans and chimps differ at level of gene splicing
Date:11/14/2007

TORONTO, ON Researchers are closer to understanding why humans differ so greatly from chimpanzees in the way they look, behave, think, and fight off disease, despite having genes that are nearly 99% identical.

Innovative research from the University of Torontos Centre for Cellular and Biomolecular Research has uncovered potential new explanations for these glaring differences. In comparing brain and heart tissue from humans and chimpanzees, U of T Professor Benjamin Blencowe and his team, including graduate student researcher John Calarco, have discovered significant differences in the way genetic material is spliced to create proteins.

Its clear that humans are very different from chimpanzees on several levels, but we wanted to find out if it could be the splicing process that accounts for some of these fundamental differences, says Blencowe, a professor with the Banting and Best Department of Medical Research and Department of Molecular Genetics. The surprising thing we found was that six to eight per cent of the alternative splicing events we looked at were showing differences, which is quite significant. And those genes that showed differences in splicing are associated with a range of important processes, including susceptibility to certain diseases.

Splicing is the process by which the coding regions of genes are joined to generate genetic messages that specify the production of proteins, the key structural and functional constituents of cells. Splicing can occur in alternative ways in the same genetic message to generate more than one type of protein. The new findings reveal that the alternative splicing process differs significantly between humans and chimpanzees.

The study, appearing tomorrow in the Journal of Genes and Development, could have implications for the future study of disease in humans and chimpanzees, Blencowe says.

Identifying what makes us different can be very important to understandi
'/>"/>

Contact: Christa Poole
christa.poole@utoronto.ca
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... A sulfur-oxidizing bacterial group called SUP05 will play an ... the world,s oceans as oxygen minimum zones expand, according ... of the National Academy of Sciences . , University ... seasonally anoxic fjord, Canada,s Saanich Inlet, to chart how ... , "Our study paints a very detailed picture of ...
(Date:7/23/2014)... habit of getting tangled and forming knots. Scientists study ... to disentangle them (e.g. useful for gene sequencing techniques). ... Studies (SISSA) in Trieste and his team have been ... and their dynamics. In their latest paper, just published ... with Marco Di Stefano, first author and PhD student ...
(Date:7/23/2014)... on sophisticated equipment, trained personnel, and detection dogs ... terrorist attacks. A revolutionary new electronic chip with ... job much easier. , The groundbreaking nanotechnology-inspired sensor, ... University ,s School of Chemistry and Center for ... company Tracense, picks up the scent of explosives ...
Breaking Biology News(10 mins):Research charts the ecological impact of microbial respiration in the oxygen-starved ocean 2Nano-sized chip "sniffs out" explosives far better than trained dogs 2
... sets off a medical guessing game with life or death ... vary from year to year. So each season authorities must ... the flu they should produce vaccines against. Even when ... Americans annually, according to the Centers for Disease Control and ...
... that for loggerhead sea turtles in the Northwest Atlantic, the ... climate conditions in the year or two prior to the ... produced by these animals in a given year. ... increases since 2008 may be a recovery response in this ...
... climate change tend to focus on comprehensive, emissions-focused measures: ... a tax on all carbon emissions. But a new ... approach involving separate targeting of energy choices and ... an important role in achieving emission reductions. The ...
Cached Biology News:Stanford researchers take a step toward developing a 'universal' flu vaccine 2Stanford researchers take a step toward developing a 'universal' flu vaccine 3Stanford researchers take a step toward developing a 'universal' flu vaccine 4Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 2Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 3Loggerhead sea turtle nesting activity driven by recent climate conditions and returning nesting 4Study finds piece-by-piece approach to emissions policies can be effective 2Study finds piece-by-piece approach to emissions policies can be effective 3
(Date:7/23/2014)... DES MOINES, Iowa (PRWEB) July 23, 2014 ... will join the business as vice president of Agricultural ... from Mendel Biotechnology where he served most recently as ... brings extensive biotechnology and business leadership in the seed ... DuPont Pioneer,” said Paul E. Schickler , president ...
(Date:7/23/2014)... 23, 2014 Shire plc ... global specialty biopharmaceutical company, and ArmaGen, a US ... licensing and collaboration agreement for AGT-182, an investigational ... of both the central nervous system (CNS) and ... II). This collaboration strengthens Shire,s rare disease pipeline ...
(Date:7/23/2014)... 2014 China Cord Blood Corporation (NYSE: CO ... provider of cord blood collection, laboratory testing, hematopoietic stem cell processing, ... multi-product healthcare company catering to the mother and child segment, today ... across the PRC, Singapore , Hong ... , the Philippines and ...
(Date:7/23/2014)... MD (PRWEB) July 23, 2014 a2z ... and ChirpE Mobile App, AACC Pathfinder, in its ... offerings. AACC’s annual meeting is planned for July 29-31, ... the place to be to connect with global leaders ... lab management, and other areas of breaking science in ...
Breaking Biology Technology:DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 2Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 3Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 4Shire Enters Strategic Licensing and Collaboration Agreement With ArmaGen 5China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 2China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 4AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 2AACC Enhances Attendee Experience at Its 2014 Annual Meeting & Clinical Lab Expo with a2z-Powered ChirpE Photo Booth and Mobile App 3
... International, Inc. (OTCQX: DATA), a technology and services company ... industry, today announced the Company,s selection as a 2011 ... year. "Being once again recognized as ... dedication DATATRAK and its employees have to bringing a ...
... In the computer displays of medical equipment in ... a major role. But a discovery reported from the ... crystal, which have been found to change their ordering ... very low concentrations of a particular bacterial lipid, might ...
... Switzerland, May 20, 2011 Syngenta announced today that ... facility adjacent to its existing research campus in Research ... is scheduled to begin in June 2011, will focus ... innovative solutions to growers across the world.   ...
Cached Biology Technology:DATATRAK Recognized as 2011 Crain's Leading EDGE Award Winner 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 2Liquid crystal droplets discovered to be exquisitely sensitive to an important bacterial lipid 3Syngenta to Invest in New U.S. Genetics Research Facility 2
... Microarrays designed for pathway studies, protein-protein ... (PTB) Studies built on the flexible ... platform. These microarrays are available as ... Microarray Service. Custom Probe ...
... adult normal Mega Western Protein Array was ... Mega Western Protein Arrays are manufactured using ... tissue sources. A protein sample from each ... with a Protein molecular weight marker on ...
... Multi-User Applications Package Superior Protein Detection ... The ProXPRESS 2D Proteomic Imaging System is ... proteomic and general life science research applications. ... use of all dyes in the UV ...
... includes 7 lanes of ... Alzheimer's-diseased brain tissue including: ... frontal lobe, temporal lobe, ... and cerebellum. Patent/trademark/license (electronic): ...
Biology Products: