Navigation Links
University of Toronto biologists predict extinction for organisms with poor quality genes
Date:4/16/2012

TORONTO, ON Evolutionary biologists at the University of Toronto have found that individuals with low-quality genes may produce offspring with even more inferior chromosomes, possibly leading to the extinction of certain species over generations.

A study published in Proceedings of the National Academy of Sciences (PNAS) predicts that organisms with such genetic deficiencies could experience an increased number of mutations in their DNA, relative to individuals with high-quality genes. The research was done on fruit flies whose simple system replicates aspects of biology in more complex systems, so the findings could have implications for humans.

"Mutations play a key role in cancer and other health problems affecting humans and other species," says Nathaniel Sharp, PhD candidate in U of T's Department of Ecology & Evolutionary Biology (EEB) and lead author of the study. "Our research suggests that the problem is likely to compound over time, leading to a mutational meltdown that may devastate endangered populations, and increase the risk of health problems in families in poor condition."

Sharp and EEB professor Aneil Agrawal examined the accumulation of mutations in the fruit fly Drosophila melanogaster, the genes of which are arranged on three major chromosomes. To manipulate genetic quality, they introduced harmful mutations onto the fly's third chromosome. They then observed how the presence of these mutations affected the fitness of the second chromosome over 46 generations.

"Copies of chromosome two maintained in strains with poor-quality copies of chromosome three declined in fitness two to three times faster than those with good copies of chromosome three, suggesting that poor genetic quality elevates the mutation rate," says Sharp. While the underlying mechanism remains unknown, it could be tied to how an affected individual is less capable of repairing DNA or is more susceptible to DNA damage.

Fruit flies are especially useful for genetic studies such as this for the ability to screen for thousands of genes in thousands of flies much faster than in mammals. Flies are inexpensive to care for and reproduce rapidly, allowing for several generations to be studied in just a few months.

The researchers do, however, offer a more positive possible result of the process. "An elevated mutation rate under conditions of genetic or environmental stress could also accelerate adaptation to new environments," says Sharp.


'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert  

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Toronto biologists predict extinction for organisms with poor quality genes
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/28/2017)... 28, 2017 The report "Video ... Monitors, Servers, Storage Devices), Software (Video Analytics, VMS), and ... Global Forecast to 2022", published by MarketsandMarkets, the market ... is projected to reach USD 75.64 Billion by 2022, ... The base year considered for the study is 2016 ...
(Date:3/23/2017)... The report "Gesture Recognition and Touchless Sensing Market by Technology (Touch-based and ... 2022", published by MarketsandMarkets, the market is expected to be worth USD 18.98 ... Continue Reading ... ...      ...
Breaking Biology News(10 mins):
(Date:8/16/2017)... , ... August 16, 2017 , ... ... microbe delivery system, announced it has secured $2M in funding from an impressive ... Angels, Carmen Innovations, and SVG Thrive Fund. With this investment, 3Bar is broadening ...
(Date:8/15/2017)... ... ... Kapstone Medical is proud to announce that it has reached ... inventors develop and safeguard their latest innovations. The company has grown from a ... clients in the United States and around the world. , Company Founder and ...
(Date:8/15/2017)... NY (PRWEB) , ... August 15, 2017 , ... ... first time on Immuno-Oncology 360° (IO360°) programming through a series of upcoming panels and ... held February 7-9, 2018, at The Roosevelt Hotel in New York City. , “With ...
(Date:8/14/2017)... ... August 14, 2017 , ... The Conference Forum has confirmed the ... place on September 6, 2017 at the Marriott Copley Place in Boston, MA. , ... Informatics, and Regulatory Strategy, Pfizer Innovative Research Lab, Pfizer, who leads 19 industry speakers ...
Breaking Biology Technology: