Navigation Links
University of Toronto biologists pave the way for improved epilepsy treatments
Date:6/5/2014

gel system to determine native protein complexes in neurons, called Blue Native PAGE. The process provided the biochemical conditions necessary to preserve the protein complexes that normally exist in neurons. Blue Native PAGE is advantageous over standard gel electrophoresis, where proteins are separated from their normal protein complexes based on their molecular weights.

"The results reveal the proteins that can be targeted by drug manufacturers in order to reset imbalances that occur in neurological disorders such as epilepsy, autism spectrum disorder, schizophrenia and neuropathic pain," said Woodin. "There is no cure for epilepsy; the best available treatments only control its effects, such as convulsions and seizures. We can now imagine preventing them from occurring in the first place."

"It was the cellular mechanisms that determine the excitation-inhibition balance that needed to be identified. Now that we know the key role played by KCC2 in moderating excitatory activity, further research can be done into its occasional dysfunction and how it can also be regulated by excitatory impulses," said Mahadevan.


'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chapman University partners with the Center for Autism and Related Disorders
2. Global health grant from the Bill & Melinda Gates Foundation awarded to the University of Surrey
3. Wayne State University licenses technology to new start-up, Detroit Materials, Inc.
4. Chapman University research article wins Best of 2013 award
5. University of Maryland School of Medicine research finds drugs that may treat MERS virus
6. How octopuses dont tie themselves in knots revealed by Hebrew University scientists
7. Chapman University affiliated physicist publishes on the Aharonov-Bohm effect in Nature
8. University of Chicago chosen as a center for new cancer clinical trials network
9. University of Toronto researchers find seeing Jesus in Toast phenomenon perfectly normal
10. Arizona Sate University scientists take steps to unlock the secrets to the fountain of youth
11. Arizona State University professor is elected to the National Academy of Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... 18-22, 2014 , WHERE: , San Diego ... CA 92101 , WHAT: , Invited and ... latest research in human genetics. Examples of sessions ... on rare genetic variants in health and disease, ... sun sensitivity (Saturday, Oct. 18, 5:30-7:30 pm) , ...
(Date:8/21/2014)... La. A team of researchers at ... method for using affordable, consumer-grade 3D printers ... that can contain antibacterial and chemotherapeutic compounds ... comprised of doctoral students and research faculty ... engineering programs collaborated to create filament extruders ...
(Date:8/21/2014)... the pancreas digesting itself resulting in severe abdominal pain, ... around 20,000 patients are diagnosed with the disease resulting ... treatment is restricted to intravenous fluid and nutritional support. ... Life Sciences, who led the research, said "The major ... stones and excessive alcohol intake combined with a high ...
Breaking Biology News(10 mins):American Society of Human Genetics 2014 Annual Meeting 2Louisiana Tech University researchers use 3D printers to create custom medical implants 2Louisiana Tech University researchers use 3D printers to create custom medical implants 3Insulin offers new hope for the treatment of acute pancreatitis 2
... Software, the Uniformed Service University of the Health ... the Advancement of Military,Medicine, Inc. (HJF) have entered ... extend their collaborative endeavors in prostate disease,research. The ... differentiate patients with,favorable versus poor prognosis at the ...
... Research, which is strategically funded by BBSRC, is ... bacterial cells to combat potentially dangerous microbial infections. ... bacteria, and IFR has been studying one that ... dangerous source of hospital-acquired infections. New research is ...
... Weizmann Institute scientists have added a significant piece to the ... size as an embryo or organism grows and develops. In ... Naama Barkai and Ben-Zion Shilo and research student Danny Ben-Zvi ... in developing fruit fly wings in which the vein ...
Cached Biology News:Genomatix, USU and HJF execute a CRADA: Prostate cancer prognostic marker discovery by NGS 2Tuning natural antimicrobials to improve their effectiveness at battling superbugs 2Scale models 2
(Date:8/21/2014)... (PRWEB) August 21, 2014 ... biopharmaceutical contract development and manufacturing organization (CMO) announced ... Pharmaceuticals, Inc., an oncology company focused on the ... cancer, to manufacture the anti-prostate specific membrane antigen ... product candidate. Under the agreement the antibody ...
(Date:8/20/2014)... university inventions licensed to biotechnology firms has revealed ... open these roadblocks, the researchers suggest that better ... stage could lead to faster commercialization down the ... discoveries made in university laboratories and licensed to ... trials, which have a high failure rate. But ...
(Date:8/20/2014)... High performance computing (HPC) will ... complete climate and Earth system model to address ... , Eight national laboratories, including Lawrence Livermore ... for Atmospheric Research, four academic institutions and one ... national laboratories include Argonne, Brookhaven, Lawrence Berkeley, Los ...
(Date:8/20/2014)... 20, 2014 Not long ago, it ... should be performed late in the development cycle – ... current regulatory trends suggest that, like many things GxP, ... In recent years, multiple drug sponsors have been required ... specific questions during phase I/II. It’s not only clinical ...
Breaking Biology Technology:Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 2Gallus Enters Agreement with Progenics Pharmaceuticals, Inc. for Manufacture of Anti-PSMA Monoclonal Antibody 3Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2
... ARNA ) announced today that the company is ... Conference on September,11, 2007 at 3:30 p.m. Eastern Time ... New York City. Jack Lief, Arena,s President and Chief,Executive ... the,company and its clinical development and discovery programs. ...
... Pieris AG,a bio-pharmaceutical company developing Anticalins(R), a ... announced successful completion,of a series of preclinical ... disease. The studies reported by Pieris ... VEGF is a key factor in the ...
... the friendly bacteria beloved of yoghurt advertisers, may be ... giving us safer pork products, according to scientists speaking ... General Microbiologys 161st Meeting at the University of Edinburgh, ... from the UKs Veterinary Laboratories Agency in Weybridge, Surrey ...
Cached Biology Technology:Arena Pharmaceuticals to Present at the Bear Stearns 20th Annual Healthcare Conference 2Arena Pharmaceuticals to Present at the Bear Stearns 20th Annual Healthcare Conference 3Probiotic good bugs may control gut infections 2
... kit contains 5 ml CELLection Dynabeads (4.5 ... the human epithelial antigen EpCAM and DNase ... log enrichment of epithelial tumour cells directly ... cells clumps can be enriched from bone ...
nucleophosmin (nucleolar phosphoprotein B23, numatrin), mRNA...
Human PDGF R beta MAb (Clone # PR7212)...
... Ambion's ActivePro In Vitro ... an E.coli lysate, synthesizes ... as well as proteins ... than competing kits. This ...
Biology Products: