Navigation Links
University of Toronto biologists pave the way for improved epilepsy treatments
Date:6/5/2014

TORONTO, ON University of Toronto biologists leading an investigation into the cells that regulate proper brain function, have identified and located the key players whose actions contribute to afflictions such as epilepsy and schizophrenia. The discovery is a major step toward developing improved treatments for these and other neurological disorders.

"Neurons in the brain communicate with other neurons through synapses, communication that can either excite or inhibit other neurons," said Professor Melanie Woodin in the Department of Cell and Systems Biology at the University of Toronto (U of T), lead investigator of a study published today in Cell Reports. "An imbalance among the levels of excitation and inhibition a tip towards excitation, for example causes improper brain function and can produce seizures. We identified a key complex of proteins that can regulate excitation-inhibition balance at the cellular level."

This complex brings together three key proteins KCC2, Neto2 and GluK2 required for inhibitory and excitatory synaptic communication. KCC2 is required for inhibitory impulses, GluK2 is a receptor for the main excitatory transmitter glutamate, and Neto2 is an auxiliary protein that interacts with both KCC2 and GluK2. The discovery of the complex of three proteins is path-breaking as it was previously believed that KCC2 and GluK2 were in separate compartments of the cell and acted independently of each other.

"Finding that they are all directly interacting and can co-regulate each other's function reveals for the first time a system that can mediate excitation-inhibition balance among neurons themselves," said Vivek Mahadevan, a PhD candidate in Woodin's group and lead author of the study.

Mahadevan and fellow researchers made the discovery via biochemistry, fluorescence imaging and electrophysiology experiments on mice brains. The most fruitful technique was the application of an advanced sensitive
'/>"/>

Contact: Sean Bettam
s.bettam@utoronto.ca
416-946-7950
University of Toronto
Source:Eurekalert

Page: 1 2

Related biology news :

1. Chapman University partners with the Center for Autism and Related Disorders
2. Global health grant from the Bill & Melinda Gates Foundation awarded to the University of Surrey
3. Wayne State University licenses technology to new start-up, Detroit Materials, Inc.
4. Chapman University research article wins Best of 2013 award
5. University of Maryland School of Medicine research finds drugs that may treat MERS virus
6. How octopuses dont tie themselves in knots revealed by Hebrew University scientists
7. Chapman University affiliated physicist publishes on the Aharonov-Bohm effect in Nature
8. University of Chicago chosen as a center for new cancer clinical trials network
9. University of Toronto researchers find seeing Jesus in Toast phenomenon perfectly normal
10. Arizona Sate University scientists take steps to unlock the secrets to the fountain of youth
11. Arizona State University professor is elected to the National Academy of Sciences
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... NEW YORK , March 31, 2015  Elephant ... the "Company"), a global provider of Software Defined Network ... solutions, today announced total revenue of approximately $20.4 million ... to a restated $19.5 million for the year ended ... of calendar 2014, the Company had completed its multi-year ...
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/23/2015)... SoundView Technology Group issues a new research update ... Wocket smart wallet. SoundView was one of the selected user groups ... the Wocket in multiple scenarios and outlets. ... retailers, making both debit and credit card payments.  ... the company meets their plans in 2015, it would push ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... This press release is available in French . ... Cancer (IRIC) of the Universit de Montral have identified a ... the origin of several cancers. In an article published in ... recent discovery of a protein complex that controls the RAS/MAPK ...
... have discovered a disease mechanism that links hereditary amyotrophic lateral ... and points to a possible therapeutic target. The findings ... Nature Neuroscience . ALS is an adult-onset disease ... three to five years of diagnosis. Scott Brady, ...
... accumulating in municipal landfills, and reliance on imported oil ... new ultra-light biodegradable foam plastic material made from two ... The new substance could be used in furniture cushions, ... ACS, Biomacromolecules , a monthly journal. ...
Cached Biology News:Discovery of a mechanism that controls the expression of a protein involved in numerous cancers 2Link between 2 forms of ALS suggests drug target 2Link between 2 forms of ALS suggests drug target 3
(Date:4/24/2015)... Diego, California (PRWEB) April 24, 2015 ... announced key milestones in its allogeneic stem-cell product ... Biopharma to properly reflect the corporate strategic direction. ... our allogeneic (donor) adipose stem cell development program ... completion of our cGMP manufacturing facility and hiring ...
(Date:4/24/2015)... SAN DIEGO , April 24, 2015  Pfenex ... in the development of biosimilar therapeutics including high value ... of its follow-on public offering of 6,000,000 shares of ... of $15.50 per share. Of the shares being offered, ... 3,390,000 shares are being offered by existing stockholders. Pfenex ...
(Date:4/24/2015)... April 24 , 2015 PAREXEL International ... services provider, today announced that Partnerships in Clinical Trials ... Management, the 2015 Clinical Innovator of the Year.  The ... team for the Company,s Perceptive MyTrials ® Data-Driven ... Thursday night during the 2015 Partnership Awards in ...
(Date:4/23/2015)... Athena San Diego, an organization that accelerates ... San Diego’s technology and life science sectors, will announce ... their Gala on April 30, 2015 from 5-9pm at ... http://athenasd.org/events/ , The Pinnacle Awards recognize individuals and ... of fostering networking, risk taking and diversity of thought, ...
Breaking Biology Technology:Vet-Stem, Inc. Meets New Milestones and Changes Name to VetStem Biopharma 2Pfenex Inc. Announces Pricing Of Follow-on Offering 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 2PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 3PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 4PAREXEL Honored With 2015 Clinical Innovator Of The Year Award From Partnerships In Clinical Trials 5Athena Pinnacle Awards to Honor Executives, Corporations and Educators Working to Promote Women Leaders 2
... and BioMed Central are announcing the launch ... today, a new online community for ... opportunities and industry news. (Logo: ... http://photos.prnewswire.com/prnh/20040907/CLTU006LOGO ) (Logo: http://photos.prnewswire.com/prnh/20100916/FL66006LOGO ...
... The PhD thesis by Carlos Echeverra Arrondo, Doctor in ... "On doped semiconductor quantum dots and magnetic nanowires", studied ... The interest aroused by nanoscience and nanotechnology spurred Dr ... their size is reduced to less than one hundred ...
... SIAL ) will be presenting at the UBS ... 12:30 PM ET in New York, NY. Interested parties may ... http://investor.sigmaaldrich.com/ .  Users can click the "Webcast" icon to ... Sigma-Aldrich is a leading Life Science and High Technology ...
Cached Biology Technology:BioSpace and BioMed Central Create Global Career Community 2Ph.D. study of behavior of semiconductor crystals of size less than 100 nanometers 2
...
... Nonanoyl-N-methylglucamide White solid. Water-soluble ... readily removed by dialysis. Useful reagent ... by HPLC. Absorbance (10%, H ... O. CMC 19 - 25 mM. ...
Anti Autotaxin /ENPP2 , - (Rabbit)...
... Tecans MiniPrep series of robotic workstations ... The MiniPrep is the ideal automation ... automation of routine laboratory procedures, improving throughput, ... based Gemini for MiniPrep software allows you ...
Biology Products: