Navigation Links
University of Texas chemist receives major grant to improve detection of drug-resistant tuberculosis
Date:12/22/2011

AUSTIN, Texas -- Developing a simple, paper-based test for drug-resistant tuberculosis (TB) is the goal of a University of Texas at Austin chemist, whose project just received a $1.6 million point-of-care diagnostics grant through Grand Challenges in Global Health, an initiative created by the Bill & Melinda Gates Foundation.

The Grand Challenges initiative seeks to engage creative minds across scientific disciplines to work on solutions that could lead to breakthrough advances for people in the developing world.

Andy Ellington, professor of chemistry, will seek to develop a system for rapidly diagnosing drug-resistant TB in areas that lack the appropriate infrastructure, such as parts of Afghanistan and Africa. His project was one of 22 Grand Challenges grants announced Dec. 16.

"New and improved diagnostics to use at the point-of-care can help health workers around the world save countless lives," said Chris Wilson, director of global health discovery at the Bill & Melinda Gates Foundation. "Our hope is that these bold ideas lead to affordable, easy-to-use tools that can rapidly diagnose diseases and trigger timelier treatment in resource-poor communities."

Diagnostics for many pathogens require refrigeration, several days to culture, or analysis in advanced laboratories. Ellington's goal is to develop a real-time test using a small strip of paper that does not require refrigeration.

"It is critical to have a point-of-care, real-time test that fits the technology climate of the place where it is used," said Ellington. "You have to do tests without refrigeration, and they need to be portable, cheap and disposable. Essentially, they need to be what a home pregnancy test is. Our diagnostic would be like that but for TB."

Unique to Ellington's approach is his attempt to build a diagnostic system using synthetic DNA embedded in paper. The DNA will work much like an integrated circuit in electronics, but in this case the signal it will amplify will be the presence of the TB bacteria in saliva.

Ellington says the ultimate goal of such "molecular computation" is to develop a DNA circuit that recognizes drug-resistant TB bacteria and produces a color easily seen by the naked eye. Appropriate interventions can then be made quickly for the patient and before the TB spreads further.

"From our research and that of others, we know what all the parts are that will make this work," Ellington said. "The problem we are working on now is making the circuit sensitive enough to the minute levels of TB bacteria in a normal sample and decreasing false positives."


'/>"/>
Contact: Andy Ellington
andy.ellington@mail.utexas.edu
512-232-3424
University of Texas at Austin
Source:Eurekalert

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:5/12/2016)... DALLAS , May 12, 2016 ... has just published the overview results from the Q1 ... of the recent wave was consumers, receptivity to a ... wearables data with a health insurance company. ... choose to share," says Michael LaColla , CEO ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... WA (PRWEB) , ... June 23, 2016 , ... ... announces the release of its second eBook, “Clinical Trials Patient Recruitment and Retention ... recruitment and retention in this eBook by providing practical tips, tools, and strategies ...
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... 23, 2016 A person commits a crime, and ... to track the criminal down. An outbreak of ... Drug Administration (FDA) uses DNA evidence to track down the ... Sound far-fetched? It,s not. The FDA has increasingly used a ... of foodborne illnesses. Put as simply as possible, whole genome ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... and Mold) microbial test has received AOAC Research Institute approval 061601. , “This ... introduced last year,” stated Bob Salter, Vice President of Regulatory and Industrial Affairs. ...
Breaking Biology Technology: