Navigation Links
University of Texas chemist receives major grant to improve detection of drug-resistant tuberculosis
Date:12/22/2011

AUSTIN, Texas -- Developing a simple, paper-based test for drug-resistant tuberculosis (TB) is the goal of a University of Texas at Austin chemist, whose project just received a $1.6 million point-of-care diagnostics grant through Grand Challenges in Global Health, an initiative created by the Bill & Melinda Gates Foundation.

The Grand Challenges initiative seeks to engage creative minds across scientific disciplines to work on solutions that could lead to breakthrough advances for people in the developing world.

Andy Ellington, professor of chemistry, will seek to develop a system for rapidly diagnosing drug-resistant TB in areas that lack the appropriate infrastructure, such as parts of Afghanistan and Africa. His project was one of 22 Grand Challenges grants announced Dec. 16.

"New and improved diagnostics to use at the point-of-care can help health workers around the world save countless lives," said Chris Wilson, director of global health discovery at the Bill & Melinda Gates Foundation. "Our hope is that these bold ideas lead to affordable, easy-to-use tools that can rapidly diagnose diseases and trigger timelier treatment in resource-poor communities."

Diagnostics for many pathogens require refrigeration, several days to culture, or analysis in advanced laboratories. Ellington's goal is to develop a real-time test using a small strip of paper that does not require refrigeration.

"It is critical to have a point-of-care, real-time test that fits the technology climate of the place where it is used," said Ellington. "You have to do tests without refrigeration, and they need to be portable, cheap and disposable. Essentially, they need to be what a home pregnancy test is. Our diagnostic would be like that but for TB."

Unique to Ellington's approach is his attempt to build a diagnostic system using synthetic DNA embedded in paper. The DNA will work much like an integrated circuit in electronics, but in this case the signal it will amplify will be the presence of the TB bacteria in saliva.

Ellington says the ultimate goal of such "molecular computation" is to develop a DNA circuit that recognizes drug-resistant TB bacteria and produces a color easily seen by the naked eye. Appropriate interventions can then be made quickly for the patient and before the TB spreads further.

"From our research and that of others, we know what all the parts are that will make this work," Ellington said. "The problem we are working on now is making the circuit sensitive enough to the minute levels of TB bacteria in a normal sample and decreasing false positives."


'/>"/>
Contact: Andy Ellington
andy.ellington@mail.utexas.edu
512-232-3424
University of Texas at Austin
Source:Eurekalert

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/21/2016)... January 21, 2016 ... new market research report "Emotion Detection and Recognition Market by ... Tools (Facial Expression, Voice Recognition and Others), Services, ... forecast to 2020", published by MarketsandMarkets, the global ... reach USD 22.65 Billion by 2020, at a ...
(Date:1/18/2016)... Jan. 18, 2016  Extenua Inc., a pioneering ... the use and access of ubiquitous on-premise and ... with American Cyber.  ... leading transformational C4ISR and Cyber initiatives in support ... latest proven technology solutions," said Steve Visconti ...
(Date:1/11/2016)... Calif. , Jan. 11, 2016 Synaptics ... human interface solutions, today announced that its ClearPad ® ... integration (TDDI) products won two separate categories in the ... Mobile Innovator and Best Technology Breakthrough. The Synaptics ® ... cost, a simplified supply chain, thinner devices, brighter displays ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... , Feb. 11, 2016  Dovetail Genomics™ LLC today ... beta program for a planned metagenomic genome assembly service. ... company,s metagenomic genome assembly method in a talk on ... Biology & Technology conference in Orlando, Fla. ... highly complex datasets is difficult. Using its proprietary ...
(Date:2/11/2016)... ... , ... Global Stem Cells Group, has announced ... new facility will provide advanced protocols and state-of-the-art techniques in cellular medicine, focusing ... The new GSCG clinic is headed by four prominent Ecuadorian physicians, including Pablo ...
(Date:2/10/2016)... , Feb.10, 2016 ASAE is introducing a ... Management Companies (AMC) the option of joining or renewing ... fee determined by staff size, every employee in any ... ASAE and reap all available member benefits.   ... new organizational membership options will allow organizations of any ...
(Date:2/10/2016)... ... 2016 , ... Benchmark Research, a fully-integrated network of ... principal investigators (PI) to the roles of Chief Medical Officer, Clinical Research and ... Chu, a Benchmark Research PI in the Austin office, will assume the role ...
Breaking Biology Technology: