Navigation Links
University of Tennessee researchers find fungus has cancer-fighting power

Arthrobotrys oligospora doesn't live a charmed life; it survives on a diet of roundworm.

But a discovery by a team led by Mingjun Zhang, an associate professor of biomedical engineering at the University of Tennessee, Knoxville, could give the fungus's life more purposeas a cancer fighter.

Zhang and his team have discovered that nanoparticles produced by A. oligospora hold promise for stimulating the immune system and killing tumors. The findings are published in this month's edition of Advanced Functional Materials.

Zhang commonly looks to nature for solutions to the world's challenges. He and research associate Yongzhong Wang were examining A. oligospora's trapping mechanism for roundworms when they discovered the fungus secretes nanocomposites consisting of highly uniform nanoparticles. Nanoparticles are tiny particles that have been shown to be important in cancer therapies.

"Naturally occuring nanoparticles have drawn increasing interest from scientific communities for their biocompatibility," said Zhang. "Due to their high surface-to-volume ratio, nanoparticles have demonstrated unique optical, thermal and electronic properties. In addition, their small size allows them to easily cross cell membranes, an essential requirement for cancer therapy."

The researchers investigated the fungal nanoparticles' potential as a stimulant for the immune system, and found through an in vitro study that the nanoparticles activate secretion of an immune-system stimulant within a white blood cell line.

They also investigated the nanoparticles' potential as an antitumor agent by testing in vitro the toxicity to cells using two tumor cell lines, and discovered nanoparticles do kill cancer cells.

According to Zhang, nature faces many diseases, and offers rich mechanisms for curing them as a result of evolution. Nature-based nanostructures possess near endless diversity, which may offer novel solutions for therapeutic applications.

"This study could be the entrance into a gold mine of new materials to treat cancers," said Zhang. "Understanding how these nanostructures are formed in the natural systems will also provide templates for the synthesis of a future generation of engineered nanostructures for biomedical applications."

The researchers' approach promises to open up a new avenue for controlling the synthesis of organic nanoparticles using synthetic biology.

"This exciting discovery is the first step forward in the development of natural nanoparticle-based therapeutics for cancer treatment and demonstrates the importance of looking to nature for innovation in disease treatment," said Zhang.


Contact: Whitney Heins
University of Tennessee at Knoxville

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
(Date:10/26/2015)... and LAS VEGAS , ... Nok Labs , an innovator in modern authentication and ... today announced the launch of its latest version of ... platform enabling organizations to use standards-based authentication that supports ... Nok S3 Authentication Suite is ideal for organizations deploying ...
(Date:10/23/2015)... California , October 23, 2015 ... (SMI) announce a mobile plug and play integration of ... real-world tasks SensoMotoric Instruments (SMI) present ... wearable solutions for eye tracking and physiological data registration. ... SMI Eye Tracking Glasses 2w and physiological ...
(Date:10/22/2015)... 2015 About fingerprint biometrics ... individual with the database to identify and verify an ... loop. Pattern-based algorithms are used to match an individual,s ... was introduced in 1986, which is being used by ... criminal. Technavio,s analysts forecast the global fingerprint ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... ... November 24, 2015 , ... Copper is an essential ... bound to proteins, copper is also toxic to cells. With a $1.3 million ... (WPI) will conduct a systematic study of copper in the bacteria Pseudomonas aeruginosa ...
(Date:11/24/2015)... Inc., a worldwide provider of clinical research services headquartered in ... has set a new quarterly earnings record in Q3 of 2015.  ... Q3 of 2014 to Q3 of 2015.   ... the establishment of an Asia-Pacific office to ... and Mexico , with the establishment ...
(Date:11/24/2015)... ... November 24, 2015 , ... The Academy of Model ... Group (SIG), MultiGP, also known as Multirotor Grand Prix, to represent the First–Person View ... years. Many AMA members have embraced this type of racing and several new model ...
(Date:11/24/2015)... Ltd. (OTCQB: TIKRF) today announced that its Annual General Meeting of Shareholders ... Israel time, at the law offices of Goldfarb Seligman ... Floor, Tel Aviv, Israel . ... to the Board of Directors; , election of Liat ... an amendment to certain terms of options granted to our Chief Executive ...
Breaking Biology Technology: