Navigation Links
University of Tennessee researchers find fungus has cancer-fighting power
Date:12/4/2012

Arthrobotrys oligospora doesn't live a charmed life; it survives on a diet of roundworm.

But a discovery by a team led by Mingjun Zhang, an associate professor of biomedical engineering at the University of Tennessee, Knoxville, could give the fungus's life more purposeas a cancer fighter.

Zhang and his team have discovered that nanoparticles produced by A. oligospora hold promise for stimulating the immune system and killing tumors. The findings are published in this month's edition of Advanced Functional Materials.

Zhang commonly looks to nature for solutions to the world's challenges. He and research associate Yongzhong Wang were examining A. oligospora's trapping mechanism for roundworms when they discovered the fungus secretes nanocomposites consisting of highly uniform nanoparticles. Nanoparticles are tiny particles that have been shown to be important in cancer therapies.

"Naturally occuring nanoparticles have drawn increasing interest from scientific communities for their biocompatibility," said Zhang. "Due to their high surface-to-volume ratio, nanoparticles have demonstrated unique optical, thermal and electronic properties. In addition, their small size allows them to easily cross cell membranes, an essential requirement for cancer therapy."

The researchers investigated the fungal nanoparticles' potential as a stimulant for the immune system, and found through an in vitro study that the nanoparticles activate secretion of an immune-system stimulant within a white blood cell line.

They also investigated the nanoparticles' potential as an antitumor agent by testing in vitro the toxicity to cells using two tumor cell lines, and discovered nanoparticles do kill cancer cells.

According to Zhang, nature faces many diseases, and offers rich mechanisms for curing them as a result of evolution. Nature-based nanostructures possess near endless diversity, which may offer novel solutions for therapeutic applications.

"This study could be the entrance into a gold mine of new materials to treat cancers," said Zhang. "Understanding how these nanostructures are formed in the natural systems will also provide templates for the synthesis of a future generation of engineered nanostructures for biomedical applications."

The researchers' approach promises to open up a new avenue for controlling the synthesis of organic nanoparticles using synthetic biology.

"This exciting discovery is the first step forward in the development of natural nanoparticle-based therapeutics for cancer treatment and demonstrates the importance of looking to nature for innovation in disease treatment," said Zhang.


'/>"/>

Contact: Whitney Heins
wheins@utk.edu
865-974-5460
University of Tennessee at Knoxville
Source:Eurekalert

Related biology news :

1. University of Houston study shows BP oil spill hurt marshes, but recovery possible
2. University of Alberta led research may have discovered how memories are encoded in our brains
3. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
4. Marshall University study may lead to new treatments for prostate cancer
5. University leads £6 million EU project to tackle obesity
6. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. University of Toronto biologists predict extinction for organisms with poor quality genes
9. University of Minnesota invention helps advance reliability of alternative energy
10. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
11. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016   Acuant , the leading ... has partnered with RightCrowd ® to ... Management, Self-Service Kiosks and Continuous Workforce Assurance. ... functional enhancements to existing physical access control ... with an automated ID verification and authentication ...
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/9/2016)... , June 9, 2016  Perkotek an innovation leader in attendance control systems is ... log work hours, for employers to make sure the right employees are actually signing ... http://photos.prnewswire.com/prnh/20160609/377486LOGO ... ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)...   Ginkgo Bioworks , a leading organism ... today awarded as one of the World Economic ... most innovative companies. Ginkgo Bioworks is engineering biology ... world in the nutrition, health and consumer goods ... customers including Fortune 500 companies to design microbes ...
(Date:6/23/2016)... ... June 23, 2016 , ... ... its second eBook, “Clinical Trials Patient Recruitment and Retention Tips.” Partnering with experienced ... this eBook by providing practical tips, tools, and strategies for clinical researchers. , ...
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... ... 23, 2016 , ... Supplyframe, the Industry Network for electronics ... Lab . Located in Pasadena, Calif., the Design Lab’s mission is to bring ... designed, built and brought to market. , The Design Lab is Supplyframe’s physical ...
Breaking Biology Technology: