Navigation Links
University of Southern California scientists reveal natural process that blocks viruses
Date:4/17/2013

The human body has the ability to ward off viruses by activating a naturally occurring protein at the cellular level, setting off a chain reaction that disrupts the levels of cholesterol required in cell membranes to enable viruses to enter cells. The findings, discovered by researchers in molecular microbiology and immunology at the Keck School of Medicine of USC, hold promise for the development of therapies to fight a variety of viral infections.

"Previous studies have shown that our bodies are already equipped to block viruses such as Ebola, influenza, West Nile, and SARS," said Jae U. Jung, principal investigator and distinguished professor and chair of the Molecular Microbiology and Immunology Department. The study, "The antiviral effector IFITM3 disrupts intracellular cholesterol homeostasis to block viral entry," was published in the journal Cell Host & Microbe on April 17, 2013.

"We showed how this occurs," Jung said. "When a virus tries to enter, the immune system gets stimulated by interferon, which produces almost 300 host proteins, including IFITM3. This protein then disrupts the interaction between two other proteins, which, in turn, significantly increases the level of cholesterol in cells, and thereby blocks the virus."

Jung added that the increase in cholesterol is only within the endosome compartment of cells and has no impact on or effect from the level of cholesterol in the bloodstream.

Joining Jung in the study were Samad Amini-Bavil-Olyaee, Keck School postdoctoral research associate and first author of the paper, as well as Youn Jung Choi, Keck School graduate student and second author, and researchers from the University of California, Riverside and Scripps Research Institute. The research was funded by the National Institutes of Health (grants CA082057, CA31363, CA115284, DE019085, AI073099, AI083025, HL110609) and the Fletcher Jones Foundation.

Scientists long have known that interfe
'/>"/>

Contact: Leslie Ridgeway
lridgewa@usc.edu
323-442-2823
University of Southern California - Health Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Houston engineering researchers theories to be tested in space
2. University of Tennessee professors research shows Gulf of Mexico resilient after spill
3. Mercyhurst Universitys new DNA sequencer to accelerate scientific research in region
4. Student named universitys first Lawrence scholar, researching at national laboratory
5. University of Tennessee professor links massive prehistoric bird extinction to human colonization
6. University of Montreal researchers discover how drug prevents aging and cancer progression
7. University of Californias unofficial favorite sea slug poised to make a comeback
8. University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
9. Columbia University Medical Center/NY-Presbyterian experts at AAN
10. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
11. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... , July 23, 2014 BioCatch, ... detection, announced today it has been named in Gartner,s ... Market Guide replaces Gartner,s well-known Magic Quadrant for Web ... BioCatch as one of several vendors to deliver passive ... will become a standard feature of at least 30% ...
(Date:7/23/2014)... governments struggle to deal with ever-growing piles of electronic ... of just how much there is and where it ... Environmental Science & Technology , their study found that ... floods into just seven developing countries with major ... , Knut Breivik and colleagues note that the export ...
(Date:7/23/2014)... 2C increase in temperature around the world by 2050, ... Intergovernmental Panel on Climate Change (IPCC), may be advantageous ... involved in the growth of forage plants such as ... livestock grazing in tropical countries such as Brazil., The ... in the Department of Biology at the Ribeiro Preto ...
Breaking Biology News(10 mins):BioCatch Featured in Gartner's 2014 Online Fraud Detection Market Guide 2BioCatch Featured in Gartner's 2014 Online Fraud Detection Market Guide 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 4
... HOUSTON -- (Aug. 16, 2010) -- A new ... and other human activity has completely obscured the natural ... "The natural factors that influence carbon dioxide cycling ... the radiocarbon signature of the river to reflect those ...
... of some of the most repugnant smells on earth, but ... has a sense of smell of its own. A team ... first time that bacteria have a molecular "nose" that is ... today in Biotechnology Journal , their study shows how ...
... infrared laser can make a heart beat faster. Scientists ... pulsed light can pace contractions in an avian embryonic heart, ... pacing of the embryonic heart," will be published in the ... 15, 2010. According to the scientists, this non-invasive device ...
Cached Biology News:A river flipped: Humans trump nature on Texas river 2A river flipped: Humans trump nature on Texas river 3Bacteria breakthrough is heaven scent 2A heart beats to a different drummer 2
(Date:7/23/2014)... Last year, Formedix celebrated ... global provider of data management solutions for clinical trials. ... system for electronic data capture (EDC) and clinical data ... study execution tools added TrialMaster to its Transform for ... of Transform for TrialMaster, is being released this week, ...
(Date:7/23/2014)... 2014  Having the right people at the table ... business growth and achieving clinical and operational goals. The ... Summit, July 20-22, 2014, in San Diego ... and healthcare experts discussing how partnerships have positively impacted ... & Chief Executive Officer of Cape Regional Medical Center ...
(Date:7/23/2014)... julio de 2014 ADB International Group ... anunciado hoy una asociación con Austen BioInnovation Institute ... el Instituto), para el propósito de llevar el ... de señal bioeléctrica (el E-QURE BST Device), al ... tiene una importante experiencia en cicatrización de heridas, ...
(Date:7/23/2014)... 23, 2014 StemGenex® , the ... the US aimed at improving the lives of patients ... study for Parkinson’s disease. StemGenex believes that a ... therapy are paramount when providing care to patients with ... stem cell therapy accessible to the millions of individuals ...
Breaking Biology Technology:Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 2ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 3ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 4ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 5ADB International Group Inc. anuncia una asociación con Austen BioInnovation Institute 6StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3
... 25 /PRNewswire/ - EastMed Inc., the medical manufacturing company ... received FDA clearance to market its flagship product, uresta(TM) ... are delighted to get the official word from the ... Inc. "Uresta (TM) Continence Care offers an innovative and ...
... The Atlantica BioEnergy Task Force today completed a two-day ... education leaders from across Atlantic Canada and Maine, to ... "The global forest industry is rapidly changing ... for environmentally sustainable ways to best use our wood-based ...
... Bio Group, LLC -- a North,American Advisory firm -- ... Review Commission, to conduct special analyses on China,s continuing,developmental ... of merely focusing on the top-tiered,areas of Beijing, Shanghai, ... examined for the project. , ...
Cached Biology Technology:Atlantica Bioenergy Task Force hosts industry and government leaders 2Atlantica Bioenergy Task Force hosts industry and government leaders 3
... is a type I eukaryotic topoisomerase that ... (also called right- and left-handed supercoils) from ... reaction is a covalently closed, circular DNA ... DNA Topoisomerase I does not absolutely require ...
... DNA Modification Kit contains reagents required to ... sample. In the bisulfite reaction, all unmethylated ... to uracils, while 5-methylcytosines remain unaltered. Thus, ... differ depending on whether the DNA is ...
... EnzChek Pyrophosphate Detection Kit,provides a fast, ... the inorganic pyrophosphate (PPi ) produced,by ... as DNA and,RNA polymerizations, cyclic AMP ... the enzymatic activation of fatty acids ...
... Premixed solution for high PCR specificity ... the combination of enzyme with unique ... nonspecific amplification provided by the ... handling convenient Master Mix and ...
Biology Products: