Navigation Links
University of South Florida and Draper team to create advanced devices for testing malaria drugs
Date:2/8/2011

the liver is the first target of the disease. The parasite is carried there after it enters the bloodstream through the bite of an infected mosquito. Once inside the liver, the infecting parasites for most types of malaria multiply and rupture liver cells, escaping back into the bloodstream. (In vivax malaria, some parasites can remain dormant in the liver for extended periods before infecting the blood.) The parasites, now modified to attack red blood cells, rapidly create more parasites, which spread throughout the bloodstream in waves.

Thus, the researchers are concentrating on the liver stage of the malaria life cycle for several reasons:

  • First, at this initial stage of human infection there are fewer parasites -- hundreds or a few thousand in the liver compared to millions once parasites start replicating in the bloodstream. That improves the odds of eliminating the parasite, Dr. Kyle said.

  • Second, vivax has the potential to lay dormant in the liver and re-activate months or years after treatment, causing relapses of malaria. While parasites are in the liver, the person does not feel sick. Once parasites enter the bloodstream, disease symptoms emerge, including chills, fever, headache, body aches, vomiting and exhaustion. If untreated, the deadly falciparum strain can quickly escalate to severe anemia, convulsions, brain damage and coma. "The drugs available to treat the bloodstream stages don't work in the liver," Dr. Adams said. "So if you could get rid of parasites in the liver stage, you could essentially prevent vivax malaria and the transmission of infection."

  • Third, the only drug effective in attacking the liver's reservoir of dormant malaria parasites to help prevent recurrences of vivax malaria is risky for widespread use. Administering Primaquine to people with a red blood cell enzyme deficiency, known as glucose phosphate dehydrogenase (G6PD) deficiency, may trigger severe and potentially le
    '/>"/>

Contact: Anne DeLotto Baier
abaier@health.usf.edu
813-974-3300
University of South Florida (USF Health)
Source:Eurekalert  

Page: 1 2 3 4

Related biology news :

1. Boston University School of Medicine researchers receive NIMH brain awards
2. University of Missouri professor elected to American Association for the Advancement of Science
3. University of Illinois study confirms glycerin as a feasible feedstuff for swine
4. University of Maryland shares NSF grant to study urban development impact
5. Columbia University uses technological innovation to study bone structure
6. University of Houston professor named 2010 AAAS Fellow
7. University of Houston researchers helping Pentagon build mind-controlled prosthetics
8. Washington State University researchers honored by top science society
9. Syracuse University team develops functionally graded shape memory polymers
10. Jackson Laboratory and Tufts University announce new Ph.D. track in mammalian genetics
11. University of Illinois research makes plant breeding easier
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of South Florida and Draper team to create advanced devices for testing malaria drugs
(Date:8/27/2014)... in understanding the mysteries of the human genome was ... provide the most detailed comparison yet of how the ... , The research, appearing August 28 in in ... encoded in the three species, genomes is "read out," ... chromosomes. , The results add billions of entries to ...
(Date:8/27/2014)... N.C. -- Duke University researchers have identified a gene ... called OSCA1, encodes a protein in the cell membrane ... adjusts the plant,s water conservation machinery accordingly. , ... associate professor of biology at Duke. , The ... Nature , could make it easier to feed the ...
(Date:8/27/2014)... requires nerve cells to rearrange existing patterns of activity ... patterns, a study of monkeys has found. The scientists ... electrical activity of brain cell networks. The study was ... "We looked into the brain and may have seen ... said Aaron Batista, Ph.D., an assistant professor at the ...
Breaking Biology News(10 mins):Encyclopedia of how genomes function gets much bigger 2Encyclopedia of how genomes function gets much bigger 3Encyclopedia of how genomes function gets much bigger 4Water 'thermostat' could help engineer drought-resistant crops 2Scientists plug into a learning brain 2Scientists plug into a learning brain 3
... abnormality that appears to prevent some men from conceiving ... contraceptive, according to University of Iowa researchers reporting their ... American Journal of Human Genetics . Although ... and have proven very effective for family planning, no ...
... A major effort from within the Aspergillus community ... supplement by the Elsevier journal Fungal Genetics ... provides extensive studies based on the genome analysis ... nidulans. The publication was enabled by Eurofungbase, a ...
... student Alistair Boettiger has amassed a beautiful collection of ... them in his computer. He and George Oster, ... mathematical neuroscientist Bard Ermentrout, have written a computer program ... principles developed to explain how the brain works and ...
Cached Biology News:Gene discovery could lead to male contraceptive 2Mollusks taste memories to build shells 2Mollusks taste memories to build shells 3Mollusks taste memories to build shells 4
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
(Date:8/27/2014)... In 2013, Lawrence Livermore ... National Security LLC (LLNS), was awarded more ... state-of-the-art laser system for the European Union's Extreme ... in the Czech Republic. , When commissioned to ... the " High repetition-rate Advanced Petawatt Laser System ...
(Date:8/27/2014)...   MSC , a healthcare performance improvement company ... appointment of Mary Beth Loesch to President ... experience preparing companies for rapid growth and market expansion, ... of Corporate Development and Healthcare. In that role, she ... well as corporate strategy and marketing. Previously, Loesch served ...
(Date:8/27/2014)... Dallas, TX (PRWEB) August 27, 2014 ... professional and in-depth study on the current state of ... The report provides a basic overview of the industry, ... analysis and Chinese domestic market analysis are provided with ... of the market. A comparison between the international and ...
Breaking Biology Technology:Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3MSC names Mary Beth Loesch President and CEO 2Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2
... SAN DIEGO, Oct. 4 Orexigen® Therapeutics, Inc. (Nasdaq: ... the treatment of obesity, today announced the schedule of ... taking place at the 28th Annual Scientific Meeting of ... the San Diego Convention Center, October 8-12, 2010.Sunday, October ...
... Pharmaceuticals, Inc. (NASDAQ: OGXI ) announced today that ... Investor Forum on Wednesday, October 6 at 10:30 a.m. PDT ... Live webcasts from this conference will be available through the ... http://ir.oncogenex.com . Webcast replays will be available approximately two hours ...
... RAMAT GAN, Israel, October 4, 2010 ... ... ... are keyed by longUrl, so we need to grab the first one. for (var r in data.results) ...
Cached Biology Technology:Orexigen® Therapeutics Announces Upcoming Data Presentations at the 28th Annual Scientific Meeting of The Obesity Society 2OncoGenex Pharmaceuticals to Present at the 9th Annual BIO Investor Forum 2EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 2EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 3EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 4EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 5EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 6EarlySense's EverOn(R) Central Display Station (CDS) Receives FDA Clearance 7
Immunogen: Synthetic peptide (aa sequence is considered to be commercially sensitive) Storage: -20 C, Avoid Freeze/Thaw Cycles...
...
TRIzol Reagents are ready-to-use monophasic solutions of phenol and guanidine isothiocyanate suitable for isolating total RNA DNA and proteins (16)....
...
Biology Products: