Navigation Links
University of Pittsburgh cardiologists identify new cardiac arrest gene
Date:10/31/2007

lator into the chests of patients who are clinically found to be at high risk.

In this study we found that GPD1-L, while not an ion channel itself, is a trafficking gene that allows the sodium channel to find its way to the cell membrane. The mutation interferes with the trafficking and leads to potentially fatal arrhythmias, said Dr. London. Equally important, we suspect that the function of the native GPD1-L gene and the mutant are influenced by oxidative stress, a process which interferes with the bodys natural ability to repair itself from antioxidant assaults, e.g., pollution, smoking or stress. Also, patients with Brugada syndrome only rarely have symptoms; they have this genetic mutation all the time. So, the question now is, why do arrhythmias or sudden death happen on any one particular day" Something else is happening concurrently with this mutation to trigger the potentially lethal rhythm problems. With the identification of this new GPD1-L gene, we hope to identify other new genes along with entirely new pathways that stabilizes the rhythm of the heart, increasing our understanding of the mechanisms that lead to sudden death in this particular condition, added Dr. London.

Using positional cloning and gene sequencing on a family affected with Brugada syndrome, Dr. London and colleagues identified a mutation in a previously unstudied gene, GPD1-L, on chromosome 3p24. This mutation impairs the hearts natural electrical ability to beat in a coordinated manner and maintain a stable rhythm. To date, only ion channel genes had been shown to cause Brugada syndrome.

The patient affected with Brugada syndrome in this study was first referred to Dr. London and colleagues more than 10 years ago. Since that time, a total of 195 family members have now been enrolled and ECGs have been repeated every six months. To date, implantable cardiac defibrillators (ICDs) have been placed in four affected patients. The original family member has had
'/>"/>

Contact: Maureen McGaffin
McGaffinME@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. University of Manchester makes made-to-measure skin and bones a reality using inkjet printers
2. New protein discovered by Hebrew University researchers
3. Next Generation Body Scanner Launched By The University Of Manchester
4. Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher
5. Green catalyst destroys pesticides and munitions toxins, finds Carnegie Mellon University
6. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
7. Carnegie Mellon University research reveals how cells process large genes
8. University of Delaware researchers develop cancer nanobomb
9. University of Arizona plant scientists to unravel maize genome
10. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
11. University of Utah to help build bionic arm
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... step has been made to help better identify and treat ... abnormal narrowing and enlarging of medium sized arteries in the ... other organs causing damage. In a new report appearing in ... , scientists provide evidence that that FMD may not be ... show a connection to abnormalities of bones and joints, as ...
(Date:7/31/2014)... they are an iconic symbol of tropical resorts ... landscape. Some, like Hawaii,s State Flower- Hibiscus ... relatively few botanists and Hawaiian conservation workers, however, ... related group of plants known as Hibiscadelphus ... Hibiscus species are in fact highly endangered. Until ...
(Date:7/31/2014)... , July 31, 2014 NXT-ID, Inc., ... growing m-commerce market, reminds investors and consumers wanting ... wallet, Wocket™, that it will be on-air today, July ... Wocket smart wallet will be featured in a ... television show that airs on the History Channel, ...
Breaking Biology News(10 mins):Scientists discover biochemical mechanisms contributing to fibromuscular dysplasia 2Brother of Hibiscus is found alive and well on Maui 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 2NXT-ID's Next Generation Biometric Smart Wallet Featured on NewsWatch Consumer Show on the History Channel and FYI Network Today, July 31st 3
... Bren School-based authors of a study published Jan. 20 in ... marine organisms resulting from exposure to a nanoparticle that had ... Lead author and assistant research biologist Robert Miller and ... professors and lead scientists at the UC Center for Environmental ...
... A molecule embedded in the membrane of human liver ... of hepatitis C virus, the first step in hepatitis C ... Chicago College of Medicine. The cholesterol receptor offers a ... drug may already exist, say the researchers, whose findings were ...
... The many factors that contribute to how cells communicate and ... understood, but researchers at Baylor College of Medicine ... fuse, and in the process, created a new physiological membrane ... edition of the journal PLoS Biology . "Within ...
Cached Biology News:Nano form of titanium dioxide can be toxic to marine organisms 2Entry point for hepatitis C infection identified 2Membrane fusion a mystery no more 2
(Date:7/31/2014)... CollabRx, Inc. (NASDAQ: CLRX), a leading provider ... today announced that it will hold an investor conference ... financial results for the first quarter of fiscal 2015 ... the current fiscal year. , The dial-in number for ... 2014, at 5 p.m. EDT (2 p.m. PDT) is ...
(Date:7/31/2014)... 2014  Smith & Nephew (LSE:SN, NYSE: ... today announced its entry into the forefoot market ... Repair System. Comprised of three separate repair options, ... ligament repair and reconstruction, a metatarsal osteotomy guide, ... (PIP) fusion, also known as hammer toe correction. ...
(Date:7/31/2014)... Calif. (PRWEB) July 31, 2014 Held ... diagnosed patients with an overview of the disease and ... of drug side effects, as well as updates on ... grateful to Dr. Sandy Srinivas for organizing this educational ... of kidney cancer. “Sandy and her colleagues have put ...
(Date:7/31/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
Breaking Biology Technology:CollabRx, Inc. Schedules First Quarter Fiscal Year 2015 Financial Conference Call and Business Update 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5
... ,The Wisconsin Biotechnology and Medical Device Association ... Marketing Communications to provide services to its members. ... state trade association and will hold workshops on branding ... organizations have also launched a Web site called ...
... I wrote about the emergence of some new angel groups in ... VCs and funds focused on early stage funding. I have been ... good reason for this as most of the Midwests biotech companies ... cousins. There has also been a dearth of funding for this ...
... week to merge its Imaging and Printing Group and its ... (IPSG) is a major milestone in HPs journey to become ... two units, HP has a unified and convincing product message ... the key that turns HPs consumer message into overdrive. , ...
Cached Biology Technology:Midwest angel investment in life sciences on the rise 2Midwest angel investment in life sciences on the rise 3Midwest angel investment in life sciences on the rise 4Midwest angel investment in life sciences on the rise 5Midwest angel investment in life sciences on the rise 6HP charges toward the living room 2HP charges toward the living room 3
Request Info...
Automated -80° C sample library for microplates and cryotube racks in SBS format; for integration into automated processes....
Automated -80° C sample library for microplates and cryotube racks in SBS format; for integration into automated processes....
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
Biology Products: