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University of Pennsylvania researchers zero in on the tiniest members in the war on cancer
Date:12/13/2007

sands of additional genes. Activation of Myc therefore profoundly changes the program of genes that are expressed in cancer cells."

"Still, we needed to determine whether any of these Myc-regulated microRNAs played a direct role in cancer," Thomas-Tikhonenko said.

The Penn team individually reintroduced several of the repressed miRNAs into mouse lymphomas that also had high levels of Myc and measured the effect on lymphoma progression in animals. They found that at least five of the miRNAs could stop cancer growth.

"While this result was not entirely surprising, we had no idea that cancer suppression by microRNAs could be so powerful," Thomas-Tikhonenko said.

Mendell also notes that RNA-based therapies have had some success in animal models, and researchers might potentially find a wide range of miRNAs that can stop cancers in their tracks.


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Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

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