Navigation Links
University of Pennsylvania researchers zero in on the tiniest members in the war on cancer
Date:12/13/2007

PHILADELPHIA - Researchers from the University of Pennsylvania and Johns Hopkins University have uncovered another reason why one of the most commonly activated proteins in cancer is so dangerous. As reported in Nature Genetics this week, the Myc protein can stop the production of at least 13 microRNAs, small pieces of nucleic acid that help control which genes are turned on and off.

Furthermore, in several instances, re-introducing repressed miRNAs into Myc-containing cancer cells suppressed tumor growth in mice, raising the possibility that a gene-therapy approach could be an effective therapy for treating certain cancers.

Andrei Thomas-Tikhonenko, an associate professor in the Department of Pathobiology in Penns School of Veterinary Medicine, and a research team led by Joshua Mendell, assistant professor at the McKusick-Nathans Institute of Genetic Medicine at Johns Hopkins, analyzed more than 300 miRNAs in both human and mouse lymphoma cells.

Mendells team had previously found that Myc could turn on one particular group of growth-promoting miRNAs called the miR-17-92 cluster in lymphoma cells. In those cells that had high amounts of Myc protein, the researchers found significant changes in the quantities of at least 13 miRNAs.

"The surprising aspect, considering our miR-17-92 results," Tsung-Cheng Chang and Duonan Yu, lead co-authors on the study, wrote, "is that lots of Myc turns everything off, not on."

When they looked closer at the DNA of the lymphoma cells, the team also found that Myc was directly attaching to the DNA at the miRNA genes.

"This was further evidence that the decrease in miRNA levels was directly due to the action of Myc," says Chang said.

"This study expands our understanding of how Myc acts as such a potent cancer-promoting protein," Mendell said. "We already knew that it can directly regulate thousands of genes. Through its repertoire of miRNAs, Myc likely influences the expression of thou
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/20/2013)... 2013) - A novel vaccine study from ... research that will be unveiled at the American Association ... meeting takes place Monday, May 20 - Wednesday, May ... , "The main goal of a vaccine is ... pathogen that causes the disease", explained Dr. Hemachand Tummala, ...
(Date:5/19/2013)... at the University of California, Davis have engineered a ... for light. They report their findings today at ... Microbiology. , "In this work, we used synthetic biology ... carbon dioxide and light energy for growth) cyanobacterial metabolism ... Jordan McEwen, the lead researcher on the study. ...
(Date:5/17/2013)... (May 18, 2013) The AGA Research Foundation announced ... the relationship between the gut microbiota, one of today,s ... disease. , The AGA Research Awards Panel selected ... Massachusetts General Hospital and Harvard Medical School, Boston, as ... Dr. Chan will receive $25,000 of funding, commencing in ...
Breaking Biology News(10 mins):Germ-fighting vaccine system makes great strides in delivery 2New gut microbiome research to explore red meat -- colorectal cancer pathway 2
... with epilepsy carry might enable doctors to better predict ... suggest basic findings by researchers at the Duke University ... University College London. Patients often undergo a lengthy process ... anti-epilepsy drugs appropriate for them. , The researchers found ...
... anthropology expedition to Ethiopia's Lake Turkana basin, researchers have ... are roughly 195,000 years old. The researchers believe ... all trace to an ancient line that first evolved ... as 50,000 years ago. , Ian McDougall of Australian ...
... Professor Frank J. Slack at Yale University has identified a ... cancer, presenting new possibilities for diagnosis and treatment. The work ... Developmental Cell. , The oncogene Ras is out of control ... or activated by mutation. According to Slack, a member of ...
Cached Biology News:Gene variations explain drug dose required to control seizures 2Gene variations explain drug dose required to control seizures 3Gene variations explain drug dose required to control seizures 4New Clues Add 40,000 Years to Age of Human Species 2New Clues Add 40,000 Years to Age of Human Species 3New Clues Add 40,000 Years to Age of Human Species 4Yale Scientists Find MicroRNA Regulates Ras Cancer Gene 2
(Date:5/21/2013)... Alpha Source, Inc., a Wisconsin-based ... exhibiting for the 13th consecutive year at the ... 2013 Conference and Expo. The conference brings together ... healthcare technologies. This year’s event will be held ... , The three-day event draws over 1,500 healthcare ...
(Date:5/21/2013)... NC (PRWEB) May 21, 2013 ... financial services company for clinical trials, announced today ... Spend Solutions, LLC. Clinverse’s ClinPay® FLS eClinical ... investigator payment process. SpendMD ™, Aggregate ... complete solution for tracking and reporting transfer of ...
(Date:5/21/2013)... As the R&D sector becomes increasingly ... industry to deliver better products, faster. Collaborations between ... often means turning big ideas into reality, within ... with Sensidose AB and Recipharm, is one example ... market sooner. The partnership resulted in the development ...
(Date:5/21/2013)... ROCKVILLE, Md. , May 21, 2013 /PRNewswire/ ... "Phase 1 study of margetuximab (MGAH22), an Fc-modified ... solid tumors expressing the HER2 oncoprotein," will be ... American Society of Clinical Oncology during the Developmental ... June 3 at 4:15 – 4:30 PM.  The ...
Breaking Biology Technology:Alpha Source, Inc. to Exhibit at the AAMI 2013 Conference and Expo 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The Development of an Innovative Microtablet Dosage Form, a Success Story: Live Webinar Hosted by Xtalks 2MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation at ASCO; Initiates Phase 2 Clinical Study to Evaluate Activity of Margetuximab in Patients with Metastatic Breast Cancer 2MacroGenics Announces Margetuximab (MGAH22) Phase 1 Data Presentation at ASCO; Initiates Phase 2 Clinical Study to Evaluate Activity of Margetuximab in Patients with Metastatic Breast Cancer 3
... 2010 Physicians at Thomas Jefferson University Hospital reported ... for fully automated interpretation of coronary CT angiography (cCTA) ... coronary artery disease (CAD) in the major coronary arteries ... in Chicago at the Radiological Society of North America ...
... between scientists in Donostia-San Sebastian and the University of Kiel ... determine and control the number of atoms in contact between ... same time as the electric current passing through the union ... Nanotechnology journal. One of the key problems in ...
... led by the European Science Foundation to identify the ... goes beyond space-related technologies to bring in expertise from ... and nanotechnology to energy, nuclear propulsion and robotics. ... and give scientists new tools. Yet currently space organisations ...
Cached Biology Technology:Rcadia COR Analyzer System Safely Rules Out Coronary Artery Disease in Main Coronary Arteries and Branch Vessels 2Bridging between Earth and space: technology breakthroughs for scientific progress 2
Prostaglandin E2 Luminex Standard Product Lines: Unspecified...
Rabbit polyclonal to HMGB1 (rating: ****) ( Abpromise for all tested applications). entrezGeneID: 3146 SwissProtID: P09429...
Eppendorf tube holder, for Tube rack 175 x 12 mm, 100. Category: Chromatography Systems & Accessories, Systems....
ERalpha (Ser 104/106)...
Biology Products: