Navigation Links
University of Nevada School of Medicine physiology professor earns $1.2 million grant over four years to study motility of internal anal sphincter muscle
Date:4/21/2010

RENO, Nev. -- Kathleen Keef, Ph.D., professor of physiology and cell biology at the University of Nevada School of Medicine, has been awarded a four-year, $1.2 million grant from the National Institute of Health to study the control of motility in the internal anal sphincter.

This is Keef's second major NIH RO1 grant in the last 10 years for research with significant implications for fecal incontinence.

Approximately five percent of the general community and 15 percent of adults over the age of 50 suffer from fecal incontinence. This disorder greatly reduces the quality of life for millions of Americans and can lead to depression, anxiety, social isolation, loss of employment, and institutionalization.

The combined financial burden for treating fecal and urinary incontinence in the United States exceeds $26 billion per year. However, even in 2010, fecal incontinence remains the "unspoken affliction" rarely discussed by patients and under reported to physicians. In spite of both financial and quality of life issues our understandings of the causes underlying this disorder, as well as our ability to prevent or treat this disorder, remain poor.

Keef's grant investigates the internal anal sphincter (IAS), a specialized ring of muscle located at the end of the gastrointestinal tract that plays a central role in maintaining fecal continence. In spite of its clear clinical relevance, the IAS is the least studied muscle in the gastrointestinal tract.

For the past 10 years, Keef has established herself as a leading expert on how contraction of this muscle (i.e., "motility") is controlled. Her newly funded grant seeks to further explore this issue by focusing on several unique properties of the IAS including differences in the structural design of this muscle, differences in the types of cells that participate in the control of muscle contraction and differences in the mechanisms by which nerves regulate con
'/>"/>

Contact: Anne McMillin
amcmillin@medicine.nevada.edu
University of Nevada, Reno
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A study by the MUHC and McGill University opens a new door to understanding cancer
2. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
3. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
4. Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces
5. Binghamton University researchers investigate evolving malaria resistance
6. Antioxidant to retard wrinkles discovered by Hebrew University researcher
7. Society for General Microbiology 161st Meeting, University of Edinburgh
8. Boston University biomedical engineers find chink in bacterias armor
9. KAUST and American University in Cairo to collaborate on research and academic development
10. UNH becomes first university in nation to use landfill gas as primary energy source
11. University of Minnesota study refutes belief that black men have more aggressive prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Nevada School of Medicine physiology professor earns $1.2 million grant over four years to study motility of internal anal sphincter muscle
(Date:7/25/2014)... of Adelaide has opened the way for the development of ... In Australia, annual barley production is second only to wheat ... of the most important diseases of barley. , Senior Research ... of special growths on the cell walls of barley plants ... , The research, by the ARC Centre of Excellence in ...
(Date:7/25/2014)... (SB) is a complex congenital central nervous system ... of the neural tubes during the embryonic phase. ... and fecal incontinence and neurocognitive retardation. Such problems ... of life. Researchers at Ankara Physical Medicine and ... functional performance in children with SB, using the ...
(Date:7/25/2014)... reach puberty is influenced by ,imprinted genes,a subset of genes ... This is the first evidence that imprinted genes can ... this study were published today in the journal Nature ... is a marker for the timing of puberty in females. ... between girls, is an inherited trait, and is linked to ...
Breaking Biology News(10 mins):New hope for powdery mildew resistant barley 2Could age of first period influence development of diseases in older women? 2
... the International Symposium " Nature and Governance Biodiversity Data, Science, ... 11 to 12 February. The symposium aimed at clarifying and popularizing ... Meeting held from 13 to 15 February 2013. The ... and brought together high-ranking speakers and guests from across the world ...
... chair!" That command given by countless parents to their ... a robot that is actually a computerized model of a ... a University of Iowa research program. That,s because a ... to accurately predict the role posture plays in transferring the ...
... A team of UCLA-led researchers has identified a protein ... as a weapon against deadly human pathogenic viruses such ... designated "priority pathogens" for national biosecurity purposes by the ... In a study published in the January issue ...
Cached Biology News:Virtual vehicle vibrations 2Newly identified natural protein blocks HIV, other deadly viruses 2
(Date:7/26/2014)... July 26, 2014 Canada Endoscopy ... market data on the Canada Endoscopy Visualization Systems ... US dollars, volume (in units) and average prices ... Endoscopy Visualization Systems, Mid-Range Endoscopy Visualization Systems and ... at http://www.marketresearchreports.biz/analysis/213254 . , The report also ...
(Date:7/25/2014)... July 26, 2014 "Ischemic Stroke ... 2014" provides data on the Ischemic Stroke and ... elemental information and data relating to the clinical ... View full global Ischemic Stroke Research Report 2014 ... overview of the trial numbers and their recruitment ...
(Date:7/25/2014)... 25, 2014 Amgen (NASDAQ: AMGN ... a $0.61 per share dividend for the third quarter ... 5, 2014, to all stockholders of record as of ... About Amgen Amgen is committed to unlocking ... illnesses by discovering, developing, manufacturing and delivering innovative human ...
(Date:7/25/2014)... MA -- Trillions of bacteria live in each person,s ... help digest food and stave off harmful infections, but ... , To help shed light on the role of ... associate professor Eric Alm recently tracked fluctuations in the ... year. The findings, described in the July 25 issue ...
Breaking Biology Technology:Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 2Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 3Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 4Canada Endoscopy Visualization Systems Market Outlook to 2020: MarketResearchReports.Biz 5Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 2Ischemic Stroke and Cerebral Stroke Global Clinical Trials Review H2, 2014: MarketResearchReports.Biz 3Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3
... , Evelyn McGown, Ph.D., Jinfang Liao, M.D., Ph.D., Molecular ... Olivier Dery, BD Biosciences Clontech, Palo Alto, CA. ... INTRODUCTION , Proteins inside eukaryotic ... balance between synthesis and degradation. Whereas protein synthesis is ...
... A. Gagne, E. Robitaille, M. Harvey, J.-A. St. Pierre, D. ... Introduction , High throughput ... process is typically highly automated and can provide screening rates over 100,000 ... simple, preferably mix and read type assays, where all reagents necessary to ...
... , This study demonstrated ... platform for a helicase functional assay. Helicase activity was measured on ... the oligos was biotinylated; the other was 5' end-labeled with [ ... a [ 33 P]-biotinylated DNA duplex substrate, then immobilized on the ...
Cached Biology Technology:Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 2Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 3Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 4Measurement of proteasome inhibition in live cells in Molecular Devices microplate fluorometers 5Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 2Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 3Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 4Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 5Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers 6Evaluation of FlashPlate in a Helicase Assay 2Evaluation of FlashPlate in a Helicase Assay 3
Mouse monoclonal antibody raised against a partial recombinant AAAS. NCBI Entrez Gene ID = AAAS...
... Cosmid Cloning Kit enables you to prepare, ... unbiased primary cosmid library of genomic DNA ... sublibraries. High efficiency cosmid library construction is ... protocols. First, genomic DNA is randomly sheared ...
Mouse monoclonal antibody raised against a partial recombinant EBI3. NCBI Entrez Gene ID = EBI3...
... VersaDoc MP 4000 System is a ... system capable of supporting a wide ... chemiluminescence, densitometry, and chemiflourescence. Red, ... imaging of multiplexed fluorescent samples, reducing ...
Biology Products: