Navigation Links
University of Nevada, Reno first to show transgenerational effect of antibiotics

RENO, Nev. In a paper published today in Nature's open access journal Scientific Reports, researchers at the University of Nevada, Reno report that male pseudoscorpions treated with the antibiotic tetracycline suffer significantly reduced sperm viability and pass this toxic effect on to their untreated sons. They suggest that a similar effect could occur in humans and other species.

"This is the first research to show a transgenerational effect of antibiotics," David Zeh, chair of the Department of Biology in the College of Science, said. "Tetracycline has a significant detrimental effect on male reproductive function and sperm viability of pseudoscorpions reducing viability by up to 25 percent and now we know that effect is passed on to the next generation. We didn't see the effect in subsequent generations."

The research involved a three-generation study of the pseudoscorpion, Cordylochernes scorpioides, a small scorpion-like arachnid. To control for genetic influences, in the first generation, brothers and sisters from each of 21 broods were either treated with weekly doses of tetracycline from birth to adulthood or were reared as untreated controls. Subsequent generations were not treated with tetracycline. The antibiotic had no effect on male or female body size, sperm number or female reproduction, they found.

In the article, lead author and assistant biology professor Jeanne Zeh surmises that tetracycline may induce epigenetic changes in male reproductive tissues that may be passed to sons changes that do not alter the sequence of DNA but rather alter the way genes are expressed.

The broad-spectrum antibiotic tetracycline is commonly used in animal production, antimicrobial therapy, and for curing arthropods infected with bacterial endosymbionts such as Wolbachia. Despite more than six decades of therapeutic and agricultural use that has resulted in the evolution of widespread bacterial resistance, tetracycline is still commonly used as an additive in animal feed and as an accessible antimicrobial therapy in developing countries.

Contact: Mike Wolterbeek
University of Nevada, Reno

Related biology news :

1. Mainz University Medical Center attracts funding of Alexander von Humboldt Professorship
2. Gladstone scientist Warner C. Greene receives Washington University School of Medicine Alumni Award
3. University of Minnesota startup offers game-changing energy solutions that reduce CO2 emissions
4. Israel names Tel Aviv Universitys Renewable Energy Center a Center of Research Excellence
5. University of Minnesota invention helps advance reliability of alternative energy
6. University of Toronto biologists predict extinction for organisms with poor quality genes
7. Life expectancy may affect when you get married, divorced, have kids: Queens University study
8. A University of Tennessee professors hypothesis may be game changer for evolutionary theory
9. University leads £6 million EU project to tackle obesity
10. Marshall University study may lead to new treatments for prostate cancer
11. BGI, University of Helsinki and Wuhan University sign a MOU concerning cooperation on genomics
Post Your Comments:
Related Image:
University of Nevada, Reno first to show transgenerational effect of antibiotics
(Date:6/7/2016)... -- Syngrafii Inc. and San Antonio Credit Union (SACU) ... Syngrafii,s patented LongPen™ eSignature "Wet" solution into SACU,s ... in greater convenience for SACU members and operational ... document workflow and compliance requirements. Logo ... Highlights: ...
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... ... findings on what they believe could be a new and helpful biomarker for ... research. Click here to read it now. , Biomarkers are components ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/27/2016)... June 27, 2016  Liquid Biotech ... funding of a Sponsored Research Agreement with The ... cells (CTCs) from cancer patients.  The funding will ... levels correlate with clinical outcomes in cancer patients ... will then be employed to support the design ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
Breaking Biology Technology: