Navigation Links
University of Montreal researchers discover how drug prevents aging and cancer progression
Date:3/26/2013

University of Montreal researchers have discovered a novel molecular mechanism that can potentially slows the aging process and may prevent the progression of some cancers. In the March 23 online edition of the prestigious journal Aging Cell, scientists from the University of Montreal explain how they found that the antidiabetic drug metformin reduces the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth.

"Cells normally secrete these inflammatory cytokines when they need to mount an immune response to infection, but chronic production of these same cytokines can also cause cells to age. Such chronic inflammation can be induced, for example by smoking" and old cells are particular proficient at making and releasing cytokines says Dr. Gerardo Ferbeyre, senior author and a University of Montreal biochemistry professor. He adds that, "We were surprised by our finding that metformin could prevent the production of inflammatory cytokines by old cells ".

In collaboration with Michael Pollack of the Segal Cancer Centre of the Jewish General Hospital, McGill University, Dr. Ferbeyre and his team discovered that metformin prevented the synthesis of cytokines directly at the level of the regulation of their genes. "The genes that code for cytokines are normal, but a protein that normally triggers their activation called NF-B can't reach them in the cell nucleus in metformin treated cells", Dr. Ferbeyre explained. "We also found that metformin does not exert its effects through a pathway commonly thought to mediate its antidiabetic effects", he added. "We have suspected that metformin acts in different ways on different pathways to cause effects on aging and cancer. Our studies now point to one mechanism", noted lead authors of the study Olga Moiseeva and Xavier Deschnes-Simard
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2

Related biology news :

1. University of Californias unofficial favorite sea slug poised to make a comeback
2. University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
3. Columbia University Medical Center/NY-Presbyterian experts at AAN
4. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
5. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
6. University of Miami geologists to address the mystery of an evolution gap in reef corals
7. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
8. University of Alberta researchers bake a better loaf of bread
9. UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations
10. University of Colorado and Orphan Technologies sign agreement
11. Brown University researchers build robotic bat wing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2014)... --Research and Markets ( http://www.researchandmarkets.com/research/87pph8/global_facial ) ... Facial Recognition Market 2015-2019" report to their ... Facial recognition is a technology used ... measures the overall facial feature of a person ... distance between eyes. Facial recognition is used for ...
(Date:12/11/2014)... -- That blood pressure plays a role in human health has ... term for high blood pressure – was first described as ... that,s used in measuring blood pressure was invented in 1896. ... hypertension, its triggers and its effects. In fact, recent findings ... best ways to treat it. For example, a ...
(Date:12/10/2014)... Dec. 9, 2014  Valencell, a leader in performance ... a staggering demand from its licensees for highly accurate, ... is not solely coming from fitness and health sectors, ... "A wearable is only as useful as the ... the ultimate driver in long-term mass consumer adoption of ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... or nurture? It's the eternal question for so many ... may play a larger role than nurture when it ... , Researchers from the University of Texas at Austin ... on 674 families, each with a same-sex adolescent pair, ...
... breast cancer , A team from the University of ... a cancer vaccine based on the bacterium Listeria monocytogenes, ... vaccines, which are more properly described as immunotherapy, work ... , Using Listeria, the researchers, led by Yvonne Paterson, ...
... are being designed to battle cancer, but their use ... established tumors require tumor-reactive T cells to traffic to ... there in order to kill cancer cells. A problem ... once they reach the environment surrounding the tumor. This ...
Cached Biology News:Environment, not genes, key in family relationships 2Breast tumors in mice eradicated using cancer vaccine 2Breast tumors in mice eradicated using cancer vaccine 3
(Date:12/13/2014)... (PRWEB) December 13, 2014 CanDiag, Inc., ... spin-out company has changed its name to OncoTab, Inc. ... representation of where we are today,” said CEO and ... our platform’s applications beyond breast cancer diagnostics to include ... reflection of that evolution.” , Founded in 2011 by ...
(Date:12/13/2014)... December 12, 2014 The DNA ... in 2013, and is expected to grow at ... , Browse through the TOC of the DNA ... trends and segments, with help of various tables ... global DNA Microarray market consists of instrument, consumables, ...
(Date:12/13/2014)... (PRWEB) December 13, 2014 According to ... million people between now and 2030." If a population ... the seventh most populous state in the country. , ... gathering at the Future of North Carolina Forum on ... Do we have the necessary infrastructure in place? Enough ...
(Date:12/13/2014)... , Dec. 11, 2014 Research and Markets ... addition of the "Glucose Sensors: the Next ... http://photos.prnewswire.com/prnh/20130307/600769 The ... designs is giving hope for a better future ... monitors that can measure glucose levels accurately and ...
Breaking Biology Technology:CanDiag Inc. Expands Product Scope Under a New Name: OncoTab, Inc. 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 2DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 3DNA Microarray Market Is Expected to Grow at a CAGR of 15.2% from 2014 to 2019 - A Report by MicroMarket Monitor 4North Carolina Chamber of Commerce: Asking Questions & Gathering Answers with a Futurist 2Glucose Sensors: the Next Generation 2Glucose Sensors: the Next Generation 3
... Fair Political,Practices Commission, SANTA MONICA, Calif., Nov. 21 ... resign from the board for,violating conflict of interest rules, ... Reed intervened and attempted to influence the awarding ... Burnham Institute, where Reed is,president and chief executive., ...
... Alexza,Pharmaceuticals, Inc. (Nasdaq: ALXA ) announced ... during the 19th Annual Piper Jaffray,Health Care Conference ... Eastern,Time. The presentation will be webcast from The ... the Investor Relations tab at http://www.alexza.com ,or ...
... Incorporated,(Nasdaq: VPHM ) today announced that Vincent ... of ViroPharma, will present,at the Lazard Capital Markets ... Tuesday, November 27, 2007. The conference is being ... also announced that Michel de Rosen, president and ...
Cached Biology Technology:California Stem Cell Board Member Violates Conflict Rules; Should Resign From Committee, Consumer Group Says 2California Stem Cell Board Member Violates Conflict Rules; Should Resign From Committee, Consumer Group Says 319th Annual Piper Jaffray Health Care Conference to Webcast Alexza's Corporate Presentation 2ViroPharma to Present at Two Upcoming Healthcare Conferences 2
...
... APAgene kits are designed to rapidly and ... our patented APA Technology. APAgene provides hassle-free, ... price. All necessary ingredients are provided in ... can be used for insert-end amplification of ...
No description available in Ensembl. Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Protein YIPF6 (YIP1 family member 6). [Source:Uniprot/SWISSPROT;Acc:Q96EC8] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Biology Products: