Navigation Links
University of Montreal researchers discover how drug prevents aging and cancer progression
Date:3/26/2013

University of Montreal researchers have discovered a novel molecular mechanism that can potentially slows the aging process and may prevent the progression of some cancers. In the March 23 online edition of the prestigious journal Aging Cell, scientists from the University of Montreal explain how they found that the antidiabetic drug metformin reduces the production of inflammatory cytokines that normally activate the immune system, but if overproduced can lead to pathological inflammation, a condition that both damages tissues in aging and favors tumor growth.

"Cells normally secrete these inflammatory cytokines when they need to mount an immune response to infection, but chronic production of these same cytokines can also cause cells to age. Such chronic inflammation can be induced, for example by smoking" and old cells are particular proficient at making and releasing cytokines says Dr. Gerardo Ferbeyre, senior author and a University of Montreal biochemistry professor. He adds that, "We were surprised by our finding that metformin could prevent the production of inflammatory cytokines by old cells ".

In collaboration with Michael Pollack of the Segal Cancer Centre of the Jewish General Hospital, McGill University, Dr. Ferbeyre and his team discovered that metformin prevented the synthesis of cytokines directly at the level of the regulation of their genes. "The genes that code for cytokines are normal, but a protein that normally triggers their activation called NF-B can't reach them in the cell nucleus in metformin treated cells", Dr. Ferbeyre explained. "We also found that metformin does not exert its effects through a pathway commonly thought to mediate its antidiabetic effects", he added. "We have suspected that metformin acts in different ways on different pathways to cause effects on aging and cancer. Our studies now point to one mechanism", noted lead authors of the study Olga Moiseeva and Xavier Deschnes-Simard. Dr. Ferbeyre emphasized that, "this is an important finding with implications for our understanding on how the normal organism defends itself from the threat of cancer and how a very common and safe drug may aid in treatment of some cancers and perhaps slow down the aging process. He adds, "It remains that determining the specific targets of metformin would give us an even better opportunity of profit from its beneficial effects. That's what we want to figure out next".


'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Related biology news :

1. University of Californias unofficial favorite sea slug poised to make a comeback
2. University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
3. Columbia University Medical Center/NY-Presbyterian experts at AAN
4. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
5. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
6. University of Miami geologists to address the mystery of an evolution gap in reef corals
7. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
8. University of Alberta researchers bake a better loaf of bread
9. UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations
10. University of Colorado and Orphan Technologies sign agreement
11. Brown University researchers build robotic bat wing
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2016)... LONDON , June 2, 2016 ... Systems, Manned Platforms, Unmanned Systems, Physical Infrastructure, Support & ... intelligence provider visiongain offers comprehensive analysis of ... that this market will generate revenues of $17.98 billion ... Systems acquired DVTEL Inc, a leader in software and ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016  Liquid Biotech ... announced the funding of a Sponsored Research Agreement ... circulating tumor cells (CTCs) from cancer patients.  The ... in CTC levels correlate with clinical outcomes in ... These data will then be employed to support ...
(Date:6/24/2016)... 2016  Regular discussions on a range of subjects including ... two entities said Poloz. Speaking at a lecture ... , he pointed to the country,s inflation target, which is ... "In certain areas there ... common economic goals, why not sit down and address strategy ...
(Date:6/24/2016)... ... , ... While the majority of commercial spectrophotometers and fluorometers use the z-dimension ... are higher end machines that use the more unconventional z-dimension of 20mm. Z-dimension ... bottom of the cuvette holder. , FireflySci has developed several Agilent flow cell ...
(Date:6/23/2016)... Seattle, WA (PRWEB) , ... June 23, 2016 ... ... technology, announces the release of its second eBook, “Clinical Trials Patient Recruitment and ... patient recruitment and retention in this eBook by providing practical tips, tools, and ...
Breaking Biology Technology: