Navigation Links
University of Maryland receives $1.9M from NSF for investigations of biomolecular structure
Date:8/24/2010

COLLEGE PARK, Md. - The University of Maryland has received a $1.9 million grant from the National Science Foundation to acquire a superconducting 800 MHz Nuclear Magnetic Resonance (NMR) spectrometer that will help scientists and engineers to solve complex problems in biology and medicine. The instrument will be the highest field NMR spectrometer to be located on the College Park campus and will enable scientists to investigate the three-dimensional structure of biological molecules and study their interactions with a degree of resolution and sensitivity not previously possible.

Kwaku Dayie, associate professor of chemistry and biochemistry, is the principal investigator on the grant, and will utilize this technology to advance his research on the biophysics of RNAs (ribonucleic acids). RNAs are biological molecules that are critical to life, and that play a role in many diseases for which effective treatments are still sought.

"RNAs do a lot more in cells than we have given them credit for," explains Dayie, who is associated with the university's Center for Biomolecular Structure and Organization (CBSO). "They can speed up chemical reactions by up to 100 billion fold without the need of protein enzymes, and they can regulate gene expression just as proteins can. Being able to map out their 3D architecture using this high field NMR technology means we'll be able to see more clearly how we could target them for drug discovery and delivery."

Two other faculty members of the Department of Chemistry and Biochemistry and the CBSO, Professor David Fushman and Assistant Professor Vitali Tugarinov, and one in the Department of Chemical and Biomolecular Engineering, Assistant Professor Ganesh Sriram, will be co-principal investigators. Both Fushman and Tugarinov are experts in the study of protein structure and dynamics using NMR methods, and they will now be able decipher interactions between important biological macromolecules that they could not study before with available technologies.

Sriram will use the NMR to advance research into metabolic engineering, the modification of organisms to improve specific cellular properties. He uses stable isotope labeling to quantify carbon traffic through cells and applies this information to develop metabolic engineering strategies.

"The new higher resolution 800 MHz NMR instrument will enable us to measure isotopes more accurately, and thereby accelerate our understanding of metabolic pathways," explains Sriram. "We use NMR technology to quantify metabolic pathways in plants or organisms that might be used to produce biofuels or pharmaceuticals."

The NMR instrument will strengthen the research programs of 15 scientific groups working in several departments at the University of Maryland in College Park Chemistry and Biochemistry, Chemical and Biomolecular Engineering, Cell Biology and Molecular Genetics, and Biology as well as in the new Institute for Bioscience and Biotechnology Research (IBBR).

"We have an outstanding group of researchers with expertise in NMR spectroscopy at UM who are among the international leaders in this area," says Professor Michael Doyle, chair of the Department of Chemistry and Biochemistry. "This award will help to advance their discoveries in several biomedical research areas, and to assist others who will utilize the technology to advance their research programs."


'/>"/>

Contact: Kelly Blake
kellyb@umd.edu
301-405-8203
University of Maryland
Source:Eurekalert

Related biology news :

1. Rice University establishes National Corrosion Center
2. Case Western Reserve University researchers track Chernobyl fallout
3. Case Western Reserve University project ties soil conservation and river management together
4. Brown University and Women & Infants Hospital expand national childrens study to Bristol County
5. NIH selects Case Western Reserve University to participate in National Childrens Study
6. US Senate confirms Clemson University engineering Dean Esin Gulari to National Science Board
7. University professor stresses links between US Navy sonar and whale strandings
8. Scent on demand: Hebrew University scientists enhance the scent of flowers
9. University success at national engineering awards
10. University of Leicester professor adds new perspective to rainforest debate
11. Providing toilets, safe water is top route to reducing world poverty: UN University
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2016)... June 1, 2016 Favorable Government ... Administration and Criminal Identification to Boost Global Biometrics System ... released TechSci Research report, " Global Biometrics Market ... Forecast and Opportunities, 2011 - 2021", the global biometrics ... 2021, on account of growing security concerns across various ...
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
(Date:4/26/2016)... , April 27, 2016 ... "Global Multi-modal Biometrics Market 2016-2020"  report to their ... , The analysts forecast the global ... of 15.49% during the period 2016-2020.  ... of sectors such as the healthcare, BFSI, transportation, ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ("Biorem" or "the Company") ... shareholders, Clean Technology Fund I, LP and Clean Technology ... based venture capital funds which together hold approximately 59% ... diluted, as converted basis), that they have entered into ... holdings in Biorem to TUS Holdings Co. Ltd. ("TUS") ...
(Date:6/27/2016)... ... June 27, 2016 , ... Newly ... technologies, services and solutions to the healthcare market. The company's primary focus is ... manufacturing, sales and marketing strategies that are necessary to help companies efficiently bring ...
(Date:6/24/2016)... , June 24, 2016  Regular discussions on a ... take place between the two entities said Poloz. ... Ottawa , he pointed to the country,s ... the federal government. ... said, "Both institutions have common economic goals, why not sit ...
(Date:6/23/2016)... ... 2016 , ... Mosio, a leader in clinical research patient ... and Retention Tips.” Partnering with experienced clinical research professionals, Mosio revisits the hurdle ... and strategies for clinical researchers. , “The landscape of how patients receive and ...
Breaking Biology Technology: