Navigation Links
University of Maryland School of Medicine receives $7.9 million grant for 'super' research magnet

The University of Maryland School of Medicine has received a $7.9 million federal grant to acquire a superconducting 950 MHz Nuclear Magnetic Resonance (NMR) magnet that will help researchers unravel the mysteries of molecules and develop new agents to treat cancer, AIDS and other diseases. The grant is among the largest of its kind ever awarded by the National Center for Research Resources (NCRR), which is part of the National Institutes of Health. The funds were made available through the American Recovery and Reinvestment Act of 2009.

The proposal to acquire the two-story spectrometer (with the super magnet) was a partnership between the University of Maryland, Baltimore (UMB), and two other University of Maryland campuses the University of Maryland, Baltimore County (UMBC) and the University of Maryland, College Park (UM). The instrument will be shared equally among the three campuses.

The University of Maryland will be the only academic institution in the United States and one of only two sites in the country to have a 950 MHz NMR spectrometer once it is installed in November of 2011.

David J. Weber, Ph.D., professor of biochemistry and molecular biology at the University of Maryland School of Medicine and director of the NMR core facility at UMB, is a co-director of the grant, along with Michael F. Summers, Ph.D., of UMBC, and David Fushman, Ph.D., of UM.

The eight-ton magnet produces a supercharged magnetic field that enables scientists to investigate the three-dimensional structure of biological molecules and study their interaction with the highest degree of resolution.

"NMR spectroscopy plays a critical role in many areas of cancer research, and having a 950 MHz NMR spectrometer on our campus is a phenomenal resource for researchers at our cancer center. It will greatly enhance and speed our efforts to uncover new information about cancer and design new drugs to treat it," says Kevin J. Cullen, M.D., director of the University of Maryland Marlene and Stewart Greenebaum Cancer Center, and professor of medicine and director of the Program in Oncology at the University of Maryland School of Medicine.

"We will be the only academic facility in the country to have this powerful magnet," says E. Albert Reece, M.D., Ph.D., M.B.A., vice president of medical affairs at the University of Maryland and dean of the University of Maryland School of Medicine. "This technology is a testament to our status as a world-class research institution. The magnet will be a critical tool in our mission to use the latest in cutting-edge technologies in our labs to bring lifesaving new treatments to patients in the clinic."

The 22.3 Tesla magnet is so powerful that it could lift 50 cars. The equipment will be housed in the UMB NMR core facility, located at the University of Maryland School of Medicine, and will be used by researchers from all three campuses as well as from institutions throughout the Mid-Atlantic region.

The instrument initially will have 35 users including 10 major core users and will operate 24 hours a day, seven days a week, according to Dr. Weber.

"Being able to observe molecules at the atomic-level eliminates a great deal of guessing when you're conducting complicated molecular experiments. We will have a much better ability to look at larger molecules and protein complexes with this powerful magnet it's like working in a room with the lights turned on," Dr. Weber says.

Dr. Weber's laboratory is developing small-molecule inhibitors geared to a family of calcium-binding proteins called S100 proteins, including one that currently is being tested in a clinical study at the cancer center as a possible treatment for melanoma. Other cancer center researchers are studying ways to help repair the DNA in cells that have been damaged by cancer.


Contact: Karen E. Warmkessel
University of Maryland Medical Center

Related biology news :

1. University of Maryland co-sponsors International Conference on the Effects of Noise on Aquatic Life
2. University of Maryland partnership receives $7.9M from NIH for superconducting research magnet
3. Ben-Gurion University of the Negev professor awarded the 2010 Elkeles Prize for Cancer Research
4. Hebrew University researchers identify gene related to chronic pain
5. Scientists at University of Colorado Anschutz Medical Campus discover new fat cell
6. NJIT professor receives Fulbright to study at University of Salerno
7. University of Hawaii completes 3-year investigation of military munitions sea disposal site
8. Ben-Gurion University of the Negev researchers identify risks of hypertension in young adults
9. University of Washington professors lifetime efforts receive international recognition
10. Kids could get more whole grains from after-school snacks, University of Minnesota study finds
11. Tulane University will receive $11.2 million to lead international malaria research center
Post Your Comments:
(Date:6/2/2016)... LONDON , June 2, 2016 ... has awarded the 44 million US Dollar project, ... Security Embossed Vehicle Plates including Personalization, Enrolment, and IT Infrastructure ... world leader in the production and implementation of Identity Management ... in January, however Decatur was selected ...
(Date:5/20/2016)... , May 20, 2016  VoiceIt is excited ... with VoicePass. By working together, VoiceIt ...  Because VoiceIt and VoicePass take slightly different approaches ... increases both security and usability. ... about this new partnership. "This marketing ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: ) ... financial services, but it also plays a fundamental part in ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016 Houston Methodist Willowbrook Hospital ... Sports Association to serve as their official health ... Methodist Willowbrook will provide sponsorship support, athletic training ... association coaches, volunteers, athletes and families. ... Sports Association and to bring Houston Methodist quality ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... 2016 Andrew D ... Published recently in ... from touchONCOLOGY, Andrew D Zelenetz , discusses ... care is placing an increasing burden on healthcare ... therapies. With the patents on many biologics expiring, ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology: