Navigation Links
University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
Date:3/18/2013

movie, the love of their friends and family, and countless other daily interactions.

A comparison of the activity of the animals' brain cells in normal and stressed rats revealed that stress had no effect on the levels of serotonin in the 'depressed' brains. Instead, it was the excitatory connections that responded to serotonin in strikingly different manner. These changes could be reversed by treating the stressed animals with antidepressants until their normal behavior was restored.

"In the depressed brain, serotonin appears to be trying hard to amplify that cocktail party conversation, but the message still doesn't get through," says Dr. Thompson. Using specially engineered mice created by collaborators at Johns Hopkins University School of Medicine, the study also revealed that the ability of serotonin to strengthen excitatory connections was required for drugs like antidepressants to work.

Sustained enhancement of communication between brain cells is considered one of the major processes underlying memory and learning. The team's observations that excitatory brain cell function is altered in models of depression could explain why people with depression often have difficulty concentrating, remembering details, or making decisions. Additionally, the findings suggest that the search for new and better antidepressant compounds should be shifted from drugs that elevate serotonin to drugs that strengthen excitatory connections.

"Although more work is needed, we believe that a malfunction of excitatory connections is fundamental to the origins of depression and that restoring normal communication in the brain, something that serotonin apparently does in successfully treated patients, is critical to relieving the symptoms of this devastating disease," Dr. Thompson explains.


'/>"/>

Contact: Karen Robinson
karobinson@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia University Medical Center/NY-Presbyterian experts at AAN
2. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
3. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
4. University of Miami geologists to address the mystery of an evolution gap in reef corals
5. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
6. University of Alberta researchers bake a better loaf of bread
7. UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations
8. University of Colorado and Orphan Technologies sign agreement
9. Brown University researchers build robotic bat wing
10. Wayne State University researchers techniques enable more, faster testing of biological liquids
11. University of Arizona Engineering College pursues water technology innovation cluster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2015)... NEW YORK , March 23, 2015   ... digital property management company, today announced that the Company ... platform for both enterprise and consumers at Connect:ID on ... D.C. HOYOS Labs will highlight the IEEE ... 1U TM ; and enterprise access control system. ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/vkzvcs/iris_biometrics ) has announced ... Business Report" report to their offering. This ... Thousands. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... America . Annual estimates and forecasts are ...
Breaking Biology News(10 mins):HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 2Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 3Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 4Iris Biometrics - Global Strategic Business Report 2015: System & Network Access Control - A Robust Market Opportunity in the Offing 5
... by University of California, San Diego biochemists has discovered ... 10 trillion varieties of a single protein, a finding ... , In the September 18 advance on-line publication of ... describe the mechanism by which a virus that infects ...
... brain's central timekeeper - the biological clock that regulates waking ... of synchrony during light schedule shifts of six hours, the ... finding may explain, at least in part, why transmeridian travelers ... time zones. The new understanding could eventually lead to the ...
... five to seven million years ago, when the lineage ... to rutabagas and turnips may have been one of ... of the University of Minnesota and Richard Wrangham of ... like roots and tubers must have sustained our ancestors ...
Cached Biology News:UCSD discovery may provide novel method to generate medically useful proteins 2UCSD discovery may provide novel method to generate medically useful proteins 3New understanding of jet lag 2New understanding of jet lag 3The roots of civilization trace back to ... roots 2
(Date:5/4/2015)... - New Massive Open Online Course (MOOC) ... United States Medical Licensing Examination Elsevier ... information products and services, announced today that it has ... to help medical students prepare for the United States ... most daunting of the three exams medical students must ...
(Date:5/1/2015)...  Northwest Biotherapeutics (NASDAQ: NWBO ) ("NW Bio"), ... for solid tumor cancers, announced today that the Company ... a $40 million investment from Woodford investment funds in ... million in NW Bio on November 19, 2014.  On ... the Company for a further $40 million investment in ...
(Date:5/1/2015)... A new report by  visiongain ... reach $22.4bn in 2019. That revenue forecast and others ... Prospects 2015-2025 ,  published in March 2015. ... provide forecasts and qualitative analyses of the antithrombotic drugs ... in London, UK . It produces ...
(Date:4/30/2015)... Carolina (PRWEB) May 01, 2015 Spirax ... services, is extremely proud to announce that for the ... named as a winner of a Queen’s Award for ... for the design and manufacture of a unique flowmeter. ... the revolutionary alternative to traditional steam flow measurement. ...
Breaking Biology Technology:Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 2NW Bio Closes On $28.5 Million Second Tranche Of Woodford $40 Million Financing 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 2Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 3Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 4Antithrombotic Drugs: World Industry and Market Prospects 2015-2025 5Spirax Sarco Receives a Queen’s Award for Innovation 2Spirax Sarco Receives a Queen’s Award for Innovation 3
... To mark the launch of a new, joint Integrative ... and Florida Atlantic University (FAU) are hosting an inaugural ... the Student Union at FAU,s Boca Raton campus. The ... by the Max Planck Florida Institute; FAU; the Max ...
... thousands of lives each year, a new cost-effective rabies ... and the Serum Institute of India took an important ... study. The recently completed study showed that a new ... the serum of treated subjects equal to the current ...
... (BRONX, NY) By constructing a microscope apparatus that ... at Albert Einstein College of Medicine of ... during one of the most important "trips" in all ... (RNA) molecules from the nucleus into the cytoplasm (the ...
Cached Biology Technology:Neuroscience Symposium to Launch Max Planck Florida Institute and FAU New Graduate Program 2Neuroscience Symposium to Launch Max Planck Florida Institute and FAU New Graduate Program 3New treatment for rabies advances after successful phase 1 trial in India 2New treatment for rabies advances after successful phase 1 trial in India 3Nature study shows how molecules escape from the nucleus 2Nature study shows how molecules escape from the nucleus 3
... Channel Cell Lines ,High Quality, Functionally-Validated, Ion ... well known for having a critical role ... have a key function in pain, CNS ... channels have been investigated in therapeutic areas, ...
Mouse monoclonal antibody raised against a partial recombinant TTC3. NCBI Entrez Gene ID = TTC3...
Mouse polyclonal antibody raised against a partial recombinant SYT4. NCBI Entrez Gene ID = 6860...
Mouse monoclonal antibody raised against a partial recombinant IL31RA. NCBI Entrez Gene ID = IL31RA...
Biology Products: