Navigation Links
University of Maryland School of Medicine finds depression stems from miscommunication between brain cells
Date:3/18/2013

t the University of Maryland, where discoveries made in the laboratory can impact the clinical practice of medicine."

Depression affects more than a quarter of all U.S. adults at some point in their lives, and the World Health Organization predicts that by 2020 it will be the second leading cause of disability worldwide. Depression is also the leading risk factor for suicide, which causes twice as many deaths as murder, and is the third leading cause of death for 15-24 year olds.

The first major finding of the study was the discovery that serotonin has a previously unknown ability to strengthen the communication between brain cells. "Like speaking louder to your companion at a noisy cocktail party, serotonin amplifies excitatory interactions in brain regions important for emotional and cognitive function and apparently helps to make sure that crucial conversations between neurons get heard," says Dr. Thompson. "Then we asked, does this action of serotonin play any role in the therapeutic action of drugs like Prozac?"

To understand what might be wrong in the brains of patients with depression and how elevating serotonin might relieve their symptoms, the study team examined the brains of rats and mice that had been repeatedly exposed to various mildly stressful conditions, comparable to the types of psychological stressors that can trigger depression in people.

The researchers could tell that their animals became depressed because they lost their preference for things that are normally pleasurable. For example, normal animals given a choice of drinking plain water or sugar water strongly prefer the sugary solution. Study animals exposed to repeated stress, however, lost their preference for the sugar water, indicating that they no longer found it rewarding. This depression-like behavior strongly mimics one hallmark of human depression, called anhedonia, in which patients no longer feel rewarded by the pleasures of a nice meal or a good
'/>"/>

Contact: Karen Robinson
karobinson@som.umaryland.edu
410-706-7590
University of Maryland Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia University Medical Center/NY-Presbyterian experts at AAN
2. Eurofins MWG Operon and Queen Mary, University Of London commence genome sequencing analysis of Ash
3. University of Maryland School of Medicine discovers adaptations to explain strategies for survival on Mars
4. University of Miami geologists to address the mystery of an evolution gap in reef corals
5. University of Illinois researchers develop AFM-IR for nanometer scale chemical identification
6. University of Alberta researchers bake a better loaf of bread
7. UC Berkeley, UCSF and Stanford join forces to help commercialize university innovations
8. University of Colorado and Orphan Technologies sign agreement
9. Brown University researchers build robotic bat wing
10. Wayne State University researchers techniques enable more, faster testing of biological liquids
11. University of Arizona Engineering College pursues water technology innovation cluster
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 Research and Markets ( http://www.researchandmarkets.com/research/86ncd6/micro_market ... Market Monitor: North America Perimeter Security Systems Market" ... http://photos.prnewswire.com/prnh/20130307/600769 The North American perimeter security ... 3.6% from 2014 to 2019. Although the U.S. market ... Canada is expected to grow at a ...
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 /PRNewswire-USNewswire/ ... efforts to make it easier to detect and ... chain. Today the agency started performing ... The capability will validate the authenticity of purchased ... chain. The new quality control measures will be ...
(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2
... May 4 Strengthening its position as a ... PKI-based ePassport technology to help the Malaysian government (Jabatan Imigresen Malaysia) migrate ... , , , ... always prided itself on being at the forefront of border security," said ...
... available in German . , The hairs on ... 10 per cent decrease in fuel consumption. The plant has the ... water. Researchers at the University of Bonn, Rostock and Karlsruhe now ... the fern does this. Their results can possibly be used for ...
... Granada (UGR) have studied the natural history and conservation status ... balansae in Europe, a thorny bush that can grow ... be exclusive to Morocco. The team of scientists is calling ... of threatened species. In 2006, a research team from ...
Cached Biology News:Entrust Technology, Expertise Called on for Malaysian ePassport Project 2Entrust Technology, Expertise Called on for Malaysian ePassport Project 3Entrust Technology, Expertise Called on for Malaysian ePassport Project 4Bionic coating could help ships to economize on fuel 2Polygala balansae, a new bush to Europe, at risk of extinction in Spain 2
(Date:12/24/2014)... and NEW YORK , Dec. 23, ... open-label pilot study of mazindol in children with attention ... Therapy in December 2014 . The ... children with attention deficit/hyperactivity disorder" ( Konofal et al, ... Dec 1;8:2321-2332. eCollection 2014 ) shows that mazindol ...
(Date:12/22/2014)... GenomeDx Biosciences today announced that a new ... genomic test for prostate cancer, was able to predict ... radical prostatectomy without adjuvant therapy. Although rapid metastasis in ... tumor genomics to identify these men who have a ... advance. The study has been published online by ...
(Date:12/19/2014)... December 19, 2014 Bioject Medical ... and manufacturer of needle-free injection technology, today announced ... Immunomic Therapeutics, Inc. (“ITI”) for ITI to use ... its LAMP™ vaccine platform. , In the ... Worldwide license to the Biojector®-2000 that triggers based ...
(Date:12/19/2014)... REDWOOD CITY, Calif. , Dec. 19, 2014 ... , USA) announced today that they have been ... Technologies 1,2 is a privately held company that ... processing of next generation sequencing (NGS) data for the ... into the Roche Sequencing Unit, and will continue to ...
Breaking Biology Technology:Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 2Study Published in European Urology Shows that the Decipher Prostate Cancer Classifier is Predictive of Rapid Metastasis in High-Risk Men who have had Prostate Surgery 3Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3Bina Technologies is acquired by Roche. 2Bina Technologies is acquired by Roche. 3
... challenges , ,MADISON The white board in the ... their condition is a familiar scene in many hospitals. But ... best interest of the patient but still providing information to ... of a lecture given by Dennis Dassenko , UW ...
... of Wisconsin-Madison Department of Educational Psychology has teamed up ... Co-Lab to create new worlds in which people ... Department's Learning Sciences Program studies how human ... in UW-Madison's School of Education. "We have made digital ...
... EMD Biosciences Inc. , a supplier of premium ... it has formed a strategic partnership with The ... automation for life science applications. , ,This partnership ... and validate EMDs products on the Piccolo system, TAP's ...
Cached Biology Technology:The challenges of maintaining patient privacy and delivering secure clinical information 2The challenges of maintaining patient privacy and delivering secure clinical information 3University of Wisconsin team creates learning games 2University of Wisconsin team creates learning games 3EMD Biosciences partners with European biotech company 2
... Sigmas 10 Capillary Electrophoresis Running Buffer ... and high throughput demands of todays sequencing ... supplier of TBE to the gel-based sequencing ... large scale capacity to meet your buffer ...
... knockdown of all human, mouse, and ... Genomewide, predesigned siRNAs for a ... , Ready-to-use, convenient matching solutions for ... Cost-effective RNAi and downstream analysis ...
... Excalibur™ mid-, near- and far-infrared range FT-IR ... performance in their class. Yet all this ... Features: Highest-energy throughput: Having a larger ... compared to other conventional FT-IRs provides 300%,larger ...
... Rapid-Screen cDNA Library Panels were designed for ... sets of PCRs to identify the desired ... performed in a 96-well "Master Plate," where ... clones. Having identified the positive well(s) by ...
Biology Products: