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University of Maryland Medical Center launches genetic-testing program for cardiac patients
Date:5/14/2013

to them to determine the most appropriate treatment for their patients, who might have other medical conditions that need to be considered. The test results also are entered in the electronic medical record, where they can be accessed by other physicians.

"Knowing a patient's genotype is helping us to make more informed decisions for our patients," Dr. Vesely says. "A combination of aspirin and clopidogrel is the routine choice of medications many physicians will prescribe for their stent patients. But patients who are likely to have a poor or moderate response may be better protected by other medications or possibly a higher dose of clopidogrel. It comes down to what is best for each patient."

According to Dr. Vesely, limitations for the alternative medications include their association with higher bleeding rates. "The cost of the medications could also be a factor if patients cannot afford alternative medications or will not take them as prescribed." Newer anti-clotting medications, such as prasugrel (Effient) and ticagrelor (Brilinta), are more expensive than Plavix, which has been available as a generic since May 2012.

Dr. Robinson notes that the response from patients to genetic testing has been positive. "Patients have been very receptive to discovering this new information about themselves that can possibly have a positive impact on their future cardiovascular health," he says.

Dr. Shuldiner anticipates that the initiative will be expanded to include tests for other genes that may affect how patients respond to medications such as warfarin, an anticoagulant; simvastatin, a cholesterol-lowering drug; and codeine, a pain reliever. "Providing tailored therapy will better meet the health needs of patients and reduce the harmful side effects that can occur when a person is taking the wrong medication," he says.


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Contact: Karen Warmkessel
kwarmkessel@umm.edu
41-032-889-194-104-041-53
University of Maryland Medical Center
Source:Eurekalert

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