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University of Louisville researchers sign global licensing agreement
Date:10/30/2013

LOUISVILLE, Ky. The University of Louisville today announced that researcher Dr. Suzanne Ildstad, representing Regenerex LLC, has entered into a license and research collaboration agreement with Novartis to provide access to stem cell technology that has the potential to help transplant patients avoid taking anti-rejection medicine for life and could serve as a platform for treatment of other diseases.

The University of Louisville and Regenerex LLC announced the research collaboration agreement which will significantly enhance the university's Institute for Cellular Therapeutics' ability to carry out cutting edge research related to the Facilitating Cell, a novel cell discovered by Ildstad, a professor of surgery and director of the institute at UofL as well as CEO of Regenerex. Underpinning this collaboration is an exclusive global licensing and research collaboration agreement between Regenerex and Novartis.

Ildstad published results in a March 2012 Science Translational Medicine demonstrating the efficacy of this process, known as Facilitating Cell Therapy, or FCRx which is currently undergoing Phase II trials. Five of eight kidney transplant patients were able to stop taking about a dozen pills a day to suppress their immune systems. It was the first study of its kind where the donor and recipient did not have to be biologically related and did not have to be immunologically matched.

In a standard kidney transplant, the donor agrees to donate a kidney. In the approach being studied, the individual is asked to donate part of their immune system as well. The process begins about one month before the kidney transplant, when bone marrow stem cells are collected from the blood of the kidney donor using a process called apheresis. The donor cells are then processed, where they are enriched for developing "facilitating cells" believed to help transplants succeed. During the same time period, the recipient undergoes pre-trans
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Contact: Gary Mans
gary.mans@louisville.edu
502-852-7504
University of Louisville
Source:Eurekalert  

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