Navigation Links
University of Kansas graduate student researcher takes aim at deadly brain tumors
Date:4/2/2009

believes that ATF5 helps growth and proliferation of cancerous cells in brain tumors, where the protein is abundant.

"It's known that ATF5 is required for brain development, but once we have adult brains and they're fully developed, we don't detect any ATF5 present in adult normal brains," Ciaccio said. "Somehow the instruction for the gene that regulates ATF5 gets turned on when it's not supposed to be on anymore. And maybe that's why we have high levels of ATF5 in the cancer. Then these cells start to grow uncontrollably and that results in cancer."

To better understand ATF5, Cicaccio produces large quantities of the protein from genetically modified bacteria grown in her lab at the Multidisciplinary Research Building on KU's west campus. But proteins are complex. The KU researcher is focused on better mapping a domain of the protein called bZIP that binds to DNA, in the hopes of preventing it from attaching to genes and advancing cancer.

Ciaccio studies the ATF5 molecule's structure using KU's Nuclear Magnetic Resonance Laboratory it houses a high-tech spectrometer akin to MRIs that are used in hospitals. The 800 MHz spectrometer provides detailed, three-dimensional computer models of the protein and helps Ciaccio better analyze the bZIP structure of the ATF5 protein. Someday, with a better grasp on the intricate arrangement of the molecule, scientists could find a way to target the protein and stunt cancerous growths.

But Ciaccio's work with ATF5 is still in the basic research stage, and the road toward a useful therapy can be a long one. Ciaccio estimates that it could take at least 10 years for her research to result in a drug that could be administered to patients.

"Ideally, we'd like to see this new type of treatment that will be developed prolong lives," said Ciaccio. "But if we could also provide treatment that would have less side effects than what's available now, I think patients would jump at the chanc
'/>"/>

Contact: Brendan M. Lynch
blynch@ku.edu
785-864-8855
University of Kansas
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
2. Intruder alert: Tel Aviv Universitys Smart Dew will find you!
3. Nanyang Technological University and University of California, Berkeley pursue research alliance
4. Hebrew University professors work leads to FDA approval for product
5. The University of Miami receives grants from Royal Caribbean Cruises Ltd.s Ocean Fund
6. University researchers to develop coatings that kill superbugs
7. K-State researchers work with university in Ghana to create biofuels from native tree seeds
8. Tufts University professor receives IADR Pharmacology/Therapeutics/Toxicology Award
9. IADR Wilmer Souder Award presented to University of Colorado professor
10. Troutlodge, University of Miami sign aquaculture agreement
11. Ben-Gurion University engineers develop technique to help combat nuclear proliferation
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
University of Kansas graduate student researcher takes aim at deadly brain tumors
(Date:7/31/2015)... julho de 2015 A 10 a. ... realizada pela BGI de 22-25 de outubro de 2015, em ... A conferência está celebrando seu 10 o. aniversário este ... tornou uma das reuniões mais influentes do mundo no ... dinâmicos, entusiastas e prazerosos. A ICG-10 ...
(Date:7/31/2015)... , 31. Juli 2015 Die 10. internationale ... von BGI veranstaltet und findet vom 22. bis ... , statt. Die Konferenz ... ihrem Start 2006 ist die ICG weltweit zu ... geworden. Sie ist eines der dynamischsten, enthusiastischsten und ...
(Date:7/30/2015)... 2015 Cellecta, Inc., a U.S.-based provider ... and biomarker discovery, announced the release of its ... all human protein coding genes. CRISPR technology enables ... gene,s function. Cellecta,s new Human Whole Genome CRISPR ... so that researchers can investigate in a single ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 2Die 10. internationale Konferenz zu Genomik (ICG-10) beginnt im Oktober 3CELLECTA, INC. Announces Launch of Human Whole Genome CRISPR Knockout Library 2
... ESOF 2008 gets underway. Some major announcements before we hope to ... you have NOT registered please note: Online Registration closes June 30. ... www.esof2008.org ESOF 2008 Press briefings in Barcelona ... on Monday July 7, 11am and in Madrid Tuesday ...
... between the CSIRO/Australian Capital Ventures Limited joint venture and ... scale commercial crops of BARLEYmax unique grain ... the Director of the CSIRO Food Futures Flagship, Dr ... of insoluble and soluble fibre found in wheat or ...
... SANTA CRUZ, CA--Huge numbers of fish, seabirds, and other ... inadvertently caught during fishing operations. Known as marine bycatch, ... industry, regulatory agencies, and conservationists. One recent proposal would ... species, but a new analysis suggests that this strategy ...
Cached Biology News:New study raises concerns about proposed mitigation strategy for marine bycatch 2
(Date:7/30/2015)... ... 30, 2015 , ... As part of its 2015 growth plan and as a follow up ... business units, Whitehouse Laboratories is pleased to announce that it has begun construction on ... of Excellence and will be strictly dedicated to basic USP 51, USP 61, and USP ...
(Date:7/29/2015)... According to a new market research report, ,Global ... published by Mordor Intelligence, the Global market is expected to ... with North America being the largest ... market size. The Global market for Stem Cells is expected ... of (2015-2020).      (Logo: http://photos.prnewswire.com/prnh/20150428/740799) , ...
(Date:7/29/2015)... July 29, 2015  HealthSouth Corporation ... largest providers of post-acute healthcare services, offering both ... results of operations for the second quarter ended ... was characterized by strong volume growth in both ... EBITDA," said Jay Grinney, President and Chief Executive ...
(Date:7/29/2015)... ... 2015 , ... Brady (NYSE:BRC), a global leader in product ... align chemical container labeling with OSHA’s updated Hazard Communication (HazCom) Standard and the ... of an accurate label, and pictogram uses and meanings. , “With changes to ...
Breaking Biology Technology:Whitehouse Labs Formally Announces Plans to Open a Microbiological Laboratory 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 2Asia Pacific to Dominate the Global Stem Cell Market - Vericel Corporation, Ocata Therpeutics, Athersys Inc., Cryo-Cell International, Geron Corporation, StemCells, Inc. Among the Major Players 3HealthSouth Reports Results for Second Quarter 2015 2HealthSouth Reports Results for Second Quarter 2015 3HealthSouth Reports Results for Second Quarter 2015 4HealthSouth Reports Results for Second Quarter 2015 5HealthSouth Reports Results for Second Quarter 2015 6HealthSouth Reports Results for Second Quarter 2015 7HealthSouth Reports Results for Second Quarter 2015 8HealthSouth Reports Results for Second Quarter 2015 9HealthSouth Reports Results for Second Quarter 2015 10HealthSouth Reports Results for Second Quarter 2015 11HealthSouth Reports Results for Second Quarter 2015 12HealthSouth Reports Results for Second Quarter 2015 13HealthSouth Reports Results for Second Quarter 2015 14HealthSouth Reports Results for Second Quarter 2015 15HealthSouth Reports Results for Second Quarter 2015 16HealthSouth Reports Results for Second Quarter 2015 17HealthSouth Reports Results for Second Quarter 2015 18HealthSouth Reports Results for Second Quarter 2015 19HealthSouth Reports Results for Second Quarter 2015 20HealthSouth Reports Results for Second Quarter 2015 21HealthSouth Reports Results for Second Quarter 2015 22HealthSouth Reports Results for Second Quarter 2015 23HealthSouth Reports Results for Second Quarter 2015 24HealthSouth Reports Results for Second Quarter 2015 25HealthSouth Reports Results for Second Quarter 2015 26HealthSouth Reports Results for Second Quarter 2015 27HealthSouth Reports Results for Second Quarter 2015 28HealthSouth Reports Results for Second Quarter 2015 29HealthSouth Reports Results for Second Quarter 2015 30HealthSouth Reports Results for Second Quarter 2015 31HealthSouth Reports Results for Second Quarter 2015 32HealthSouth Reports Results for Second Quarter 2015 33
... , , , ... Media magazine,s 2009 Agency of the Year, today announces the opening of ... strategic part of the agency,s 2010 growth plan. Digitas Health has experienced ... last three years, 14 new client brand wins over the past 12 ...
... , , ANAHEIM, ... today and I see our company providing the technological platform for ... Pulwer, upon accepting the position of President/CEO from the Board of ... in business for over 30 years and maintains the largest installed ...
... , AUSTIN, Texas, July 27 Patton Medical ... injection port therapy, announced today that they have entered into a ... devices used in the treatment of diabetes. , , ... two companies are working together to design and develop the ...
Cached Biology Technology:Digitas Health Expands Adding Two Key Locations 2Digitas Health Expands Adding Two Key Locations 3Digitas Health Expands Adding Two Key Locations 4Sechrist Industries, World Leader in Hyperbaric Chambers, Announces Edward Pulwer as President/CEO 2Patton Medical Devices Partners With Unomedical to Develop and Market the i-port Advance(TM) Injection Port for People Taking Multiple Daily Injections 2Patton Medical Devices Partners With Unomedical to Develop and Market the i-port Advance(TM) Injection Port for People Taking Multiple Daily Injections 3
... siRNA Tracker Intracellular Localization Kit provides a ... deliver siRNA, of your design, in an ... tracking experiments. Subcellular localization and functional inhibition ... following introduction of the labeled siRNA into ...
Selective media for Salmonella...
... Invasion through the extracellular matrix (ECM) ... Cancer cells initiate invasion by adhering ... wall. Proteolytic enzymes, such as MMP ... covering (basement membrane) surrounding the blood vessels ...
... Gasket slide kit (1x 22K gasket/slide) G2534-60003 ... or Gasket slide kit (2x 11K gasket/slide) ... offered in either 11K or 22K microarray feature formats, ... are carefully fabricated and batch tested to ensure performance ...
Biology Products: