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University of Colorado Cancer Center genetically sequences most common bladder cancer
Date:8/11/2011

ed in many bladder cancer patients.

"When we talk about 'causes' of cancer, there's a black box between a healthy cell and the emergence of cancerous ones," says Theodorescu. "By exploring the genetic changes that take place inside this box, we can look at the links of the chain of events that lead to cancer and hopefully target specific links for therapy."

In the development of bladder cancer, this study shows that chromatin remodeling is an important link.

"We are currently well underway in performing similar sequencing with Caucasian subjects to determine if the mutations in the Caucasian population are similar to those seen in this study's Asian subjects," Theodorescu says.

After confirmation, the task will be twofold: designing genetic tests for these mutations that may allow easy, early, accurate diagnosis of bladder cancer, and developing therapies that recognize these mutations and kill the cancerous cells that hold them.


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Contact: Garth Sundem
garth.sundem@ucdenver.edu
303-724-6441
University of Colorado Denver
Source:Eurekalert

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