Navigation Links
University of Colorado Cancer Center genetically sequences most common bladder cancer
Date:8/11/2011

August 11, 2011 (Aurora, CO)--In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark reports the first genetic sequencing of urothelial (transitional) carcinoma, the most prevalent type of bladder cancer.

Recognizing the genetic mutations that make bladder cancer cells different than their healthy neighbors may allow early genetic screenings for cancer and new therapies targeting cells with these mutations. In addition, the mutations the team found are similar to those recently discovered in a host of other cancers, implying a possible common denominator in the cause of cancer in general. Specifically, in 59 percent of 97 patients with urothelial carcinoma, the team found mutations in genes responsible for chromatin remodeling the process of packaging DNA for easy duplication during cell division.

"The discovery of mutation in the UTX gene and seven similar chromatin remodeling genes is a major step toward genetic testing and treatment of bladder cancer," says Dan Theodorescu, MD, PhD, director the University of Colorado Cancer Center and an author on this work. On a grand scale, the study also provides the first-ever overview of the genetic basis of urothelial bladder cancer and implicates chromatin remodeling in its cause.

Chromatin describes the genetic contents of a cell's nucleus including the cell's DNA and the proteins that sculpt its arrangement inside the cell. During most of a cell's life, these proteins arrange DNA loosely so that its inner parts are accessible and available for use. In preparation for cell division, these proteins in the cell's chromatin constrict DNA into a tight package for efficient duplication. This squeezing is known as "chromatin remodeling." How the cell remodels and thus how it duplicates depends greatly on associated chromatin remodeling genes -- the genes this study found to be mutat
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
303-724-6441
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Durham University solar car takes on World Solar Challenge
2. University of Virginia researchers uncover new catalysis site
3. Montana State University team surprised by results of lung, mold study
4. Hebrew University student turns paper mill waste into green material for industrial applications
5. University of Houston professor co-authors PNAS paper on how bacteria move
6. Changing Planet town hall at Arizona State University: Adapting to our water future
7. Moessbauer group of Mainz University preparing for participation in Japanese moon mission
8. University of Kentucky-led research could be path to new energy sources
9. University of Houston researcher an author of multi-institutional genetic study of ovarian cancer
10. Smithsonian Conservation Biology Institute and George Mason University expand partnership
11. University of Houstons Biotech Program gets state grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... 2015 from previously communicated that it will amount to at ... 390 MSEK. Due to the rapid increase in market growth ... from the previously communicated guidance that revenue for 2015 will ... 2015 will amount to approximately 2,200 MSEK. Due ...
(Date:6/12/2015)... , June 12, 2015  Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring, ... patent to electronically capture, analyze and identify participants ... recognition methods. This system can: ... an enrollment and subsequent sign-on process is actually ...
(Date:6/9/2015)... -- Research and Markets  ( http://www.researchandmarkets.com/research/xsgs2s/gesture ) has ... & Touchless Sensing Market by Technology (Touch-based & ... (Biometric & Sanitary Equipment) & by Geography - ... offering. The total gesture recognition and ... 23.55 Billion by 2020 at a high CAGR ...
Breaking Biology News(10 mins):Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2Global Gesture Recognition & Touchless Sensing (Technology, Application & Products) Market 2015-2020 2
... bugs grow in intensive care units to develop a ... MRSA and other superbugs in the environment, scientists heard ... General Microbiologys 162nd meeting being held this week at ... a standard sampling regime to take swabs from sinks, ...
... deadliest diseases, caused by the Ebola virus, may finally ... have successfully tested several Ebola vaccines in primates and ... Dr Anthony Sanchez, from the Centers for Disease ... overview of Ebola vaccine development today (Monday 31 March ...
... Multi-Modal Biometric Identification Solution ... and Interoperability, SCHAUMBURG, Ill., March 28 ... it has been selected by the West Virginia,State ... (BIS). Motorola,s latest BIS solution features new algorithms ...
Cached Biology News:MRSA in hospital intensive care -- what's growing where? 2Vaccine for Ebola virus 2Motorola Biometric Identification System Selected by West Virginia State Police 2
(Date:6/29/2015)...  AACC, a global scientific and medical professional ... is pleased to announce that the impact factor ... increased to 7.9 in the 2014 Thomson Reuters ... Chemistry in the top 3% of all ... the research it publishes on laboratory medicine and ...
(Date:6/29/2015)... 2015 According to a new market ... Application (Diagnostics, Therapeutics, R&D), by Technology (SELEX, Other Technologies), by ... - Global Forecast to 2020", published by MarketsandMarkets, the global ... from $107.56 Million in 2015, at a CAGR of 17.89%. ... 67 F igures spread through 125 ...
(Date:6/29/2015)... 2015   For the seventh year running, Across Health ... overall digital maturity called the Multichannel Maturometer . ... not maturing fast enough. While it,s true that technology ... overall and customers are increasingly "digital natives", pharma still ... engagement.  ...
(Date:6/26/2015)... CITY, Kan. , June 26, 2015 ... PETX ), a pet therapeutics company ... of innovative biopharmaceutical products for companion animals, ... field effectiveness study of capromorelin (AT-002), the ... dogs.  Capromorelin is a small molecule that ...
Breaking Biology Technology:AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 2AACC's Journal, Clinical Chemistry, Continues to Have Significant Impact on Medical Testing, Healthcare 3Aptamers Market Worth $244.93 Million by 2020 2Aptamers Market Worth $244.93 Million by 2020 3Aptamers Market Worth $244.93 Million by 2020 4Results from Digital Maturity Study Show Pharma Lagging 2Results from Digital Maturity Study Show Pharma Lagging 3Results from Digital Maturity Study Show Pharma Lagging 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 2Aratana Therapeutics Announces Positive Pivotal Results for AT-002 3Aratana Therapeutics Announces Positive Pivotal Results for AT-002 4Aratana Therapeutics Announces Positive Pivotal Results for AT-002 5
... , Data Reported at the 2010 ASCO ... Both Time to Tumor Progression and Overall Survival in ... Arm , QUÉBEC CITY, Jan. 25 /PRNewswire-FirstCall/ ... AEZ) (the "Company"), a late-stage drug development company specialized ...
... thin films for semiconductors in electronic devices, layers of atoms ... materials grow smooth crystals, others tend to develop bumps and ... In the online edition of the journal Science ... how atoms arrange themselves into thin films. Led by assistant ...
... As ... bright spot in terms of employment growth. But that was offset by a rough ride for ... pharmaceutical companies going into 2010 are any indication, the trouble isn,t over just yet. , ... (Vocus) January 21, 2010 -- As one of ...
Cached Biology Technology:Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 2Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 3Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 4Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 5Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 6Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 7Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 8Æterna Zentaris Partner Keryx Reports a Statistically Significant Benefit in Survival from Updated Results of a Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Perifosine (KRX-0401) in the Treatment of Advanced Metastatic Colon Cancer 9Watching crystals grow provides clues to making smoother, defect-free thin films 2The MedZilla Report for January 2010 - Health Care Closes 2009 Strong, But Pharma Continues Shedding Jobs 2The MedZilla Report for January 2010 - Health Care Closes 2009 Strong, But Pharma Continues Shedding Jobs 3The MedZilla Report for January 2010 - Health Care Closes 2009 Strong, But Pharma Continues Shedding Jobs 4
...
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531...
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... skirted micro test tubes are used to ... these tubes have uniform walls for uniform ... separate O-ring screw caps. The O-rings are ... an operating range from -55 to 150 ...
Biology Products: