August 11, 2011 (Aurora, CO)--In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark reports the first genetic sequencing of urothelial (transitional) carcinoma, the most prevalent type of bladder cancer.
Recognizing the genetic mutations that make bladder cancer cells different than their healthy neighbors may allow early genetic screenings for cancer and new therapies targeting cells with these mutations. In addition, the mutations the team found are similar to those recently discovered in a host of other cancers, implying a possible common denominator in the cause of cancer in general. Specifically, in 59 percent of 97 patients with urothelial carcinoma, the team found mutations in genes responsible for chromatin remodeling the process of packaging DNA for easy duplication during cell division.
"The discovery of mutation in the UTX gene and seven similar chromatin remodeling genes is a major step toward genetic testing and treatment of bladder cancer," says Dan Theodorescu, MD, PhD, director the University of Colorado Cancer Center and an author on this work. On a grand scale, the study also provides the first-ever overview of the genetic basis of urothelial bladder cancer and implicates chromatin remodeling in its cause.
Chromatin describes the genetic contents of a cell's nucleus including the cell's DNA and the proteins that sculpt its arrangement inside the cell. During most of a cell's life, these proteins arrange DNA loosely so that its inner parts are accessible and available for use. In preparation for cell division, these proteins in the cell's chromatin constrict DNA into a tight package for efficient duplication. This squeezing is known as "chromatin remodeling." How the cell remodels and thus how it duplicates depends greatly on associated chromatin remodeling genes -- the genes this study found to be mutat
|Contact: Garth Sundem|
University of Colorado Denver