Navigation Links
University of Colorado Cancer Center genetically sequences most common bladder cancer
Date:8/11/2011

August 11, 2011 (Aurora, CO)--In an article published online this week in Nature Genetics, a University of Colorado Cancer Center team in partnership with universities in China and Denmark reports the first genetic sequencing of urothelial (transitional) carcinoma, the most prevalent type of bladder cancer.

Recognizing the genetic mutations that make bladder cancer cells different than their healthy neighbors may allow early genetic screenings for cancer and new therapies targeting cells with these mutations. In addition, the mutations the team found are similar to those recently discovered in a host of other cancers, implying a possible common denominator in the cause of cancer in general. Specifically, in 59 percent of 97 patients with urothelial carcinoma, the team found mutations in genes responsible for chromatin remodeling the process of packaging DNA for easy duplication during cell division.

"The discovery of mutation in the UTX gene and seven similar chromatin remodeling genes is a major step toward genetic testing and treatment of bladder cancer," says Dan Theodorescu, MD, PhD, director the University of Colorado Cancer Center and an author on this work. On a grand scale, the study also provides the first-ever overview of the genetic basis of urothelial bladder cancer and implicates chromatin remodeling in its cause.

Chromatin describes the genetic contents of a cell's nucleus including the cell's DNA and the proteins that sculpt its arrangement inside the cell. During most of a cell's life, these proteins arrange DNA loosely so that its inner parts are accessible and available for use. In preparation for cell division, these proteins in the cell's chromatin constrict DNA into a tight package for efficient duplication. This squeezing is known as "chromatin remodeling." How the cell remodels and thus how it duplicates depends greatly on associated chromatin remodeling genes -- the genes this study found to be mutat
'/>"/>

Contact: Garth Sundem
garth.sundem@ucdenver.edu
303-724-6441
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related biology news :

1. Durham University solar car takes on World Solar Challenge
2. University of Virginia researchers uncover new catalysis site
3. Montana State University team surprised by results of lung, mold study
4. Hebrew University student turns paper mill waste into green material for industrial applications
5. University of Houston professor co-authors PNAS paper on how bacteria move
6. Changing Planet town hall at Arizona State University: Adapting to our water future
7. Moessbauer group of Mainz University preparing for participation in Japanese moon mission
8. University of Kentucky-led research could be path to new energy sources
9. University of Houston researcher an author of multi-institutional genetic study of ovarian cancer
10. Smithsonian Conservation Biology Institute and George Mason University expand partnership
11. University of Houstons Biotech Program gets state grant
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 16, 2014 Valencell, a leader in performance biometric ... to industry leaders such as Intel, Jabra, Atlas, and ... wearable products. These products will be showcased at CES ... Vegas . "Our partners choose ...
(Date:12/11/2014)... , Dec. 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/twhjll/biometrics_market ) has announced the addition of the ... to their offering. One major trend ... continuous advances in technology, it is important to upgrade ...
(Date:12/10/2014)... been here before: you desperately need to sign into your online ... answer to your secret question. What,s your dog,s birthday? Who was ... , a digital infrastructure security company, launches the app ... with usernames, passwords and PINs – 1U TM . ...
Breaking Biology News(10 mins):Valencell PerformTek Biometrics Power the Most Accurate Wearables at CES 2015 2Biometrics Market in the APAC Region 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 2The Password is Finally Dead: Launch of 1U Mobile App Eliminates Need for All Usernames and Passwords 3
... four genes newly associated with severe childhood obesity. They ... in severely obese children. The team found that ... to maintain protein receptors known to be involved in ... for the development of new drugs against obesity. ...
... UNTIL 1 P.M. EDT, APRIL 7, 2013, Cleveland: A compound ... popular energy drinks has been found to promote atherosclerosis ... to Cleveland Clinic research published online this week in the ... that bacteria living in the human digestive tract metabolize the ...
... Kidney stones usually make their presence known suddenly, often ... Each year in the U.S. more than a million ... nephrolithiasis. The total annual cost of treatment exceeds $2.1 ... Information Clearinghouse. Although kidney stone pain may ...
Cached Biology News:Finding genes for childhood obesity 2Cleveland Clinic researchers discover new link between heart disease and red meat 2Cleveland Clinic researchers discover new link between heart disease and red meat 3Flies reveal kidney stones in-the-making 2Flies reveal kidney stones in-the-making 3
(Date:1/22/2015)... Jersey , 22 de enero de 2015  El Dr. ... hoy su llamada a nominaciones para 2015. Este prestigioso ... hecho, o tiene el potencial para hacer, contribuciones destacadas ... se aceptarán hasta el 15 de marzo de 2015 ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 Earlier this year ... Sherley, director of the Adult Stem Cell Technology Center, LLC ... under appreciated unique property of adult tissue stem cells. ... the Past, Important for the Future,” embodied the essence of ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 2Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 3Adult Stem Cell Technology Center, LLC’s Director Sherley's Address on What’s Holding Back Regenerative Medicine Featured on Omics Group Website 4
... - Before Congress takes its traditional August break, the ... human embryonic stem cell research. Let's hope a scientifically sound ... as Wisconsin follow the lead. , ,Just as Republicans in ... are GOP leaders in Washington, where President Bush suffered a ...
... Companies that are trying to justify RFID investment wholly ... efficiencies, and shrinkage in their supply chain are merely ... significant opportunities in these areas, it means that gross ... can achieve major improvements even without applying RFID. , ...
... MILWAUKEE - A group of business and technology ... $2.6 million in pledged state funds for the ... collaboration between academic researchers and private industry in southeastern ... Finance Committee by a margin of 15-1, and endorsed ...
Cached Biology Technology:Stem cell debate in Washington grows hotter as summer recess nears 2Stem cell debate in Washington grows hotter as summer recess nears 3The key to finding RFID's ROI 2The key to finding RFID's ROI 3The key to finding RFID's ROI 4Budget axe could cut SE Wisconsin tech alliance funding 2Budget axe could cut SE Wisconsin tech alliance funding 3
... (X/R) Red System consists of concentrated ... and X/R Red Buffer. The X/R ... to produce red staining that may ... , Buffer, 100 mL , Chromogen, ...
Tris-EDTA Buffer Solution, 1X, pH 8.0, sterile...
Request Info...
... 2 Detection System combines the indirect ... principle and Signets unique formulation of ... and reliablility. Signet reagents will achieve ... and automated protocols. ,Signets USA Detection ...
Biology Products: