Navigation Links
University of Arizona scientist shares in discovery of microbe filaments' power
Date:4/18/2008

Researchers from The University of Arizona and Columbia University have discovered that tiny filaments on bacteria can bundle together and pull with forces far stronger than experts had previously thought possible.

The team of researchers, including Magdalene Maggie So, a member of the BIO5 Institute and the department of immunobiology in the UA College of Medicine, studied Type IV pili or filaments on the surface of Neisseria gonorrhoeae, the bacterium that causes the infectious disease gonorrhea. The research results help them understand the role that Type IV pili play in initiating a variety of infectious diseases including tuberculosis and how retracting pili allow bacteria to crawl and to exchange genes with each other.

When a bundle of Type IV pili retracts, it pulls with a force in the nanoNewton range, which is 10 times the force of a single retracting filament. The study demonstrates the power and cooperative nature of the nanomotors that cause Type IV pili to retract.

The motor that causes these filaments to pull is one of the strongest nanomotors known in biology, So said.

In previous studies, the same group of investigators measured single filament retraction forces in the 50 to 100 picoNewton range. This force allows the bacterium to move an object 10,000 times its own body weight. Retraction forces from a bundle are roughly 10 times higher, allowing the bacterium to move objects 100,000 times its body weight.

Pilus retraction forces are an important factor in how N. gonorrhoeae starts an infection. So, who has studied these microbes for more than 20 years, says N. gonorrhoeae communicates with a human cell by pulling on it. These pulling forces perturb the normal circuitry of the cell. As a result, the infected cell is fooled into lowering its defenses against the infecting microbe.

So said that the team of investigators came up with a new method to measure the tremendous forces applied by
'/>"/>

Contact: Deborah Daun
ddaun@email.arizona.edu
520-626-2059
University of Arizona
Source:Eurekalert

Page: 1 2

Related biology news :

1. Flowers fragrance diminished by air pollution, University of Virginia study indicates
2. Pitt and University of Chicago researchers uncover process behind heart muscle contraction
3. Yale Universitys Strobel recognized for work on RNA
4. Womens health-related scientific findings presented by University of Pittsburgh researchers
5. Researchers at Stockholm University awarded the Descartes prize
6. Policing cells demand ID to tell friend from foe, say University of Pennsylvania cell engineers
7. Antarcticas coldest, darkest season draws Montana State University researchers
8. University of Colorado at Boulder awarded $1 million for biofuels research
9. Viruses evolve to play by host rules, according to University of Pennsylvania researchers
10. New whitepaper offers options for university implementation of NIH policy
11. Electronic structure of DNA revealed for 1st time by Hebrew University and collaborating researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... twist to the story of how barnyard chickens came to ... the journal Proceedings of the National Academy of Sciences ... lived 200-2300 years ago in Europe, researchers report that just ... far different from the chickens we know today. , The ... modern domestic chickens -- such as their yellowish skin -- ...
(Date:4/17/2014)... trials to treat tuberculosis could be the basis for ... bacteria, fungal infections and parasites, yet evade resistance, according ... collaborators. , Led by U. of I. chemistry professor ... drug SQ109 attacks the tuberculosis bacterium, how the drug ... to malaria and how targeting multiple pathways reduces ...
(Date:4/17/2014)... study suggests that fish consumption advisories for expecting ... long-lived contaminants like persistent organic pollutants (POPs). ... researchers including University of Toronto Scarborough PhD student ... how different levels of environmental contamination, a mother,s ... in the body influenced exposure in her children. ...
Breaking Biology News(10 mins):Ancient DNA offers clues to how barnyard chickens came to be 2Multitarget TB drug could treat other diseases, evade resistance 2Fish consumption advisories fail to cover all types of contaminants 2
... about the impact on global climate of water evaporated ... concludes that evaporated water helps cool the earth as ... demonstrating that evaporation of water from trees and lakes ... These findings, published September 14 in Environmental Research ...
... at the University of California, Riverside,s Center for Environmental ... Engineering have received two grants to further explore a ... fuels. "These grants allow for the continued happy ... research engineer at CERT. "This research has the potential ...
... For those fascinated by microbes, infection, or how medical ... Infectious Diseases, a new book just published by ASM Press, ... whose work changed the way we think about and treat ... Gaynes describes the genesis of the germ theory of disease ...
Cached Biology News:Water evaporated from trees cools global climate 2Turning waste into inexpensive, green fuel 2Turning waste into inexpensive, green fuel 3The remarkable history of medicine's battle with infectious diseases 2
(Date:1/15/2014)... SAN JOSE, California , January 15, 2014 ... conjugates for cancer, today announced the appointment of Thomas C ... has over 20 years, development experience gained in the biotechnology ... "I am delighted to welcome Tom at this ...
(Date:1/15/2014)... January 15, 2014 More than 5 ... about 1 in 3 seniors will die with Alzheimer’s ... These jaw-dropping figures have shocked many Americans into looking ... help prevent these tragic age-related cognitive disorders. Jonathan Weisman, ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, 2014 ... Country Club, 1360 Almshouse Road, Warrington, Pa. , ... solely dedicated to finding a cure for hepatitis B and ... host its annual Crystal Ball on Friday, April 11 at ...
Breaking Biology Technology:Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Monsanto Company,s (NYSE:,MON) Brett Begemann, executive ... Casale, executive vice president of strategy and,operations, ... two,conferences later this month., Both Monsanto ... company,s,business performance and expectations, strategic initiatives, product,performance, ...
... on Company,s web site, GERMANTOWN, Md., Feb. ... a pharmaceutical company focused on,developing and commercializing novel ... MiddleBrook president and CEO, will,deliver a corporate presentation ... Time., The presentation will take place as ...
... N.J., Feb. 5 Covance Inc. (NYSE:,CVD) today announced ... Biotechnology and Medical Device Conference on February 6th,at 9:20 ... the presentation at, http://www.covance.com . In order to register ... early., Covance, with headquarters in Princeton, New Jersey, ...
Cached Biology Technology:MiddleBrook Pharmaceuticals to Present at BIO CEO & Investor Conference 2008 2