Navigation Links
University of Alberta's designer compounds inhibit prion infection
Date:7/23/2012

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain.

"When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminishedand in some cases we couldn't detect any remaining misfolded prions," said West.

West and his collaborators at the U of A's Centre for Prions and Protein Folding Diseases say this research is not yet a cure, but does open a doorway for developing treatments.

"We're not ready to inject these compounds in prion-infected cattle," said David Westaway, director of the prion centre. "These initial compounds weren't created for that end-run scenario but they have passed initial tests in a most promising manner."

West notes that the most promising experimental compounds at this stage are simply too big to be used therapeutically in humans or animals.

Human exposure to prion-triggered brain disorder is limited to rare cases of Creutzfeldt-Jakob or mad cow disease. The researchers say the human form of mad cow disease shows up in one in a million people in industrialized nations, but investigating the disease is nonetheless well worth the time and expense.

"There is a strong likelihood that prion diseases operate in a similar way to neurodegenerative diseases such as Alzheimer's, which are distressingly common around the world," said West.
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. University of Tennessee Space Institute researchers develop laser technology to fight cancer
2. University of Tennessee professor wins worlds top prize for ecology, environmental science
3. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
4. Wayne State University researchers program targets safer river fishing, anglers health
5. Winemaking goes high-tech at the University of British Columbia
6. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
7. New York University scientists discover possible treatment to reduce scarring
8. Royal Astronomical Society and Oxford University Press partnership announced
9. Mainz University coordinates new EU project on the origins of human settlement
10. University of Tennessee professor receives funding for clean coal research
11. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/28/2014)... examples of complex systems. Their infrastructure equipment requires ... cooling, transport to supply fuel, and ICT systems ... network chain is interconnected with a wider network ... of UK-based scientists has studied various aspects of ... been published in EPJ B by Gaihua Fu ...
(Date:8/28/2014)... Dyslexia, the most commonly diagnosed learning disability in ... that occurs when the regions of the brain ... The use of non-invasive functional neuroimaging tools has ... dyslexia. However, most prior work has focused on ... a gap in our understanding of how multiple ...
(Date:8/28/2014)... in German . ... with the help of sophisticated assembly lines. Mobile assembly carriers, ... part of these assembly lines. In the case of a ... stages arranged in a precise spatial and chronological sequence, resulting ... , The creation of such an assembly line at molecular ...
Breaking Biology News(10 mins):Inter-dependent networks stress test 2Dyslexic readers have disrupted network connections in the brain 2Nanoscale assembly line 2Nanoscale assembly line 3
... of breast cancer that has few treatment options; , ... molecules called microRNA can be used to classify this ... new ways to identify the best therapy for individual ... COLUMBUS, Ohio A new, large-scale study ...
... debate over the use of animals in medical research ... viewpoints are becoming more nuanced, and new initiatives are ... report by The Hastings Center, "Animal Research Ethics: Evolving ... new Web site, animalresearch.thehastingscenter.org , a hub of ...
... at sea, a magnetic map is apparently responsible for their ... data collected over 56 years and reported online on February ... "To find their way back home across thousands of ... exists where they first enter the sea as juveniles," said ...
Cached Biology News:Triple-negative breast cancer subtypes identified using microRNA 2Triple-negative breast cancer subtypes identified using microRNA 3Hastings Center resources chart progress in debate over medical research with animals 2Hastings Center resources chart progress in debate over medical research with animals 3Magnetic map guides salmon home 2
(Date:8/27/2014)... Livermore, California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security ... million to develop and deliver a state-of-the-art laser ... Beamlines facility (ELI Beamlines), under construction in the ... design performance, the laser system, called the " ...
(Date:8/27/2014)... Dallas, TX (PRWEB) August 27, 2014 ... professional and in-depth study on the current state of ... The report provides a basic overview of the industry, ... analysis and Chinese domestic market analysis are provided with ... of the market. A comparison between the international and ...
(Date:8/27/2014)... MADISON, N.J. , Aug. 27, 2014 /PRNewswire/ ... significant potential to help physicians better identify early-stage ... progression and disability, according to a new study ... from Quest Diagnostics (NYSE: DGX ) ... of the 14-3-3eta protein outperformed conventional antibody-serum testing, ...
(Date:8/27/2014)... August 27, 2014 Flagship Biosciences LLC, ... services to the pharmaceutical and medical device industries, has ... The fast growing company has consolidated its histology and ... Boulder to Westminster, CO, just north of Denver. ... 7575 W. 103rd Ave., Suite 100, Westminster, CO 80021 ...
Breaking Biology Technology:LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3Trifluoroacetic Acid Industry (Asia, Europe, North America, ROW) Analysis Report Now Available at ReportsnReports.com 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 2Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 3Novel Biomarker Detects Early Rheumatoid Arthritis Better than Conventional Methods Alone, According to Journal of Rheumatology Study 4Flagship Biosciences Announces Relocation and Expansion 2
... Pipeline Efforts at 27th Annual J.P. Morgan Healthcare Conference ... (Nasdaq: GHDX ) announced today that it ... 18-gene Oncotype DX(R) colon cancer assay. Utilizing more ... the validation study will use prospectively defined endpoints to ...
... Jan. 12 WaferGen Biosystems,Inc. (OTC Bulletin ... gene,expression, genotyping, cell biology and stem cell ... successfully demonstrated the,performance of the company,s SmartChip(TM) ... the platform,s ongoing alpha testing program. ...
... - Trial conducted by Novartis to evaluate safety and ... with ribavirin in patients with genotypes 2 and 3 ... Sciences, Inc. (Nasdaq: HGSI ) today announced ... trial that will evaluate the safety and efficacy of ...
Cached Biology Technology:Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 2Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 3Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 4Genomic Health Announces Commencement of QUASAR Clinical Validation Study for Oncotype DX(R) Colon Cancer Assay 5WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 2WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 3WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 4WaferGen's SmartChip(TM) System Performance Successfully Demonstrated in Initial Phase of Alpha Testing Program 5Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 2Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 3Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 4Human Genome Sciences Announces Initiation of Phase 2b Trial of Albuferon(R) Dosed Monthly in Chronic Hepatitis C 5
Anti 7H6 Antigen (tight-junction associated protein Antigen) Monoclonal Antibody 7H6...
Goat polyclonal to Ephrin B2 ( Abpromise for all tested applications). entrezGeneID: 1948 SwissProtID: P52799...
... Rabbit Antibody to ARG. Vasopressin ... arginine vasopression peptide. Cells are found ... and fibers are found throughout the ... FA perfused tissue. ...
Mouse monoclonal [RL13] to LAP1 ( Abpromise for all tested applications). SwissProtID: Q96NW7...
Biology Products: