Navigation Links
University of Alberta's designer compounds inhibit prion infection
Date:7/23/2012

(Edmonton) A team of University of Alberta researchers has identified a new class of compounds that inhibit the spread of prions, misfolded proteins in the brain that trigger lethal neurodegenerative diseases in humans and animals.

U of A chemistry researcher Frederick West and his team have developed compounds that clear prions from infected cells derived from the brain.

"When these designer molecules were put into infected cells in our lab experiments, the numbers of misfolded proteins diminishedand in some cases we couldn't detect any remaining misfolded prions," said West.

West and his collaborators at the U of A's Centre for Prions and Protein Folding Diseases say this research is not yet a cure, but does open a doorway for developing treatments.

"We're not ready to inject these compounds in prion-infected cattle," said David Westaway, director of the prion centre. "These initial compounds weren't created for that end-run scenario but they have passed initial tests in a most promising manner."

West notes that the most promising experimental compounds at this stage are simply too big to be used therapeutically in humans or animals.

Human exposure to prion-triggered brain disorder is limited to rare cases of Creutzfeldt-Jakob or mad cow disease. The researchers say the human form of mad cow disease shows up in one in a million people in industrialized nations, but investigating the disease is nonetheless well worth the time and expense.

"There is a strong likelihood that prion diseases operate in a similar way to neurodegenerative diseases such as Alzheimer's, which are distressingly common around the world," said West.
'/>"/>

Contact: Brian Murphy
brian.murphy@ualberta.ca
780-492-6041
University of Alberta
Source:Eurekalert

Page: 1

Related biology news :

1. University of Tennessee Space Institute researchers develop laser technology to fight cancer
2. University of Tennessee professor wins worlds top prize for ecology, environmental science
3. Carnegie Mellon Universitys Biometrics Center Selected To House New Pedo-Biometrics Research and Identity Automation Lab
4. Wayne State University researchers program targets safer river fishing, anglers health
5. Winemaking goes high-tech at the University of British Columbia
6. University of Miami-led study finds winds played important role in keeping oil away from S. Fla.
7. New York University scientists discover possible treatment to reduce scarring
8. Royal Astronomical Society and Oxford University Press partnership announced
9. Mainz University coordinates new EU project on the origins of human settlement
10. University of Tennessee professor receives funding for clean coal research
11. University of North Texas Health Science Center Advances Forensic Research by Investing in Semiconductor DNA Sequencing Technology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/2/2016)... Dec. 1, 2016   SoftServe , a ... BioLock , an electrocardiogram (ECG) biosensor analysis system ... key IoT asset. The smart system ensures device-to-device ... steering wheel and mobile devices to easily ,recognize, ... As vehicle technology advances, so too must ...
(Date:11/29/2016)... 2016 Nearly one billion matches per second with ... ... DERMALOG is Germany's largest ... Identity Management. (PRNewsFoto/DERMALOG Identification Systems) ... DERMALOG is Germany's largest Multi-Biometric supplier: The company's Fingerprint Identification System ...
(Date:11/21/2016)... 2016   Neurotechnology , a provider of ... announced that the MegaMatcher On Card fingerprint matching ... the NIST Minutiae Interoperability Exchange (MINEX) III ... steps of the evaluation protocol. ... of fingerprint templates used to establish compliance of ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... 2016 More than $4.3 million was raised last ... DHMD ). The gala was held at the American Museum ... and honored Alan Alda and ... and medicine and the public understanding of science. Since the ... event has raised $40 million for the Laboratory,s research and ...
(Date:12/2/2016)... ... December 01, 2016 , ... ACEA Biosciences, Inc. announced today that ... trials for AC0010 at the World Conference on Lung Cancer 2016, taking place in ... the phase I/II clinical trials for AC0010 in patients with advanced non-small cell lung ...
(Date:12/2/2016)... ... December 01, 2016 , ... DrugDev believes the only ... a beautiful technology experience. All three tenets were on display at the 2nd Annual ... from over 40 sponsor, CRO and site organizations to discuss innovation and the future ...
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected to reach ... during the forecast period of 2016 to 2021 dominated by immunohistochemistry ... the largest share of immunohistochemistry (IHC) market, by end user.   ... , , ... across 225 pages, profiling 10 companies and supported with 181 tables ...
Breaking Biology Technology: